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However, various types of neurons and glial cells exist in the retina, and whether and how all retinal cells interact to adapt to light\/dark conditions at the cellular and molecular levels requires systematic investigation. Therefore, we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light\/dark adaptation in mice. The results demonstrated that, in addition to photoreceptors, other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light\/dark adaptation. Importantly, M\u00fcller glial cells (MGs) were identified as hub cells for intercellular interactions, displaying complex cell\u2012cell communication with other retinal cells. Furthermore, light increased the transcription of the deiodinase Dio2 in MGs, which converted thyroxine (T4) to active triiodothyronine (T3). Subsequently, light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light conditions. As cones specifically express the thyroid hormone receptor Thrb, they responded to the increase in T3 by adjusting light responsiveness. Loss of the expression of Dio2 specifically in MGs decreased the light responsive ability of cones. These results suggest that retinal cells display global transcriptional changes under light\/dark adaptation and that MGs coordinate intercellular communication during light\/dark adaptation via thyroid hormone signaling.<\/jats:p>","DOI":"10.1093\/procel\/pwad007","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:19:10Z","timestamp":1677007150000},"page":"603-617","source":"Crossref","is-referenced-by-count":26,"title":["Single-cell profiling reveals M\u00fcller glia coordinate retinal intercellular communication during light\/dark adaptation via thyroid hormone signaling"],"prefix":"10.1093","volume":"14","author":[{"given":"Min","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutao","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-8437","authenticated-orcid":false,"given":"Kun","family":"Qu","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China , Hefei 230026 , China"},{"name":"Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, University of Science 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