{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T02:58:42Z","timestamp":1794538722615,"version":"4.9.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding \u201cinvagination\u201d and \u201cmetaplasia\u201d theories. The endometrial-myometrial junction (EMJ) connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis, but its in-depth study is just beginning. Using single-cell RNA sequencing and spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, and EMJ. Within lesions, we identified unique epithelial (LGR5+) and invasive stromal (PKIB+) subpopulations, along with WFDC1+ progenitor cells, supporting a complex interplay between \u201cinvagination\u201d and \u201cmetaplasia\u201d theories of pathogenesis. Further, we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin pathways. Cell-cell communication differed markedly between ectopic and eutopic endometrium, with aberrant signaling in lesions involving pleiotrophin, TWEAK, and WNT cascades. This study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified, dysfunctional signaling, and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.1093\/procel\/pwae012","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:41:58Z","timestamp":1710402118000},"page":"530-546","source":"Crossref","is-referenced-by-count":32,"title":["Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1578-9769","authenticated-orcid":false,"given":"Tao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Affiliated Women and Children Hospital of Jiaxing University , Jiaxing 314000 , China"},{"name":"Shanghai Key Laboratory of Maternal Fetal 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Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital, School of Medicine, Zhejiang University , Hangzhou 310013 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiruo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Postgraduate training base Alliance of Wenzhou Medical University, Wenzhou Medical University , Wenzhou 325035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Affiliated Women and Children Hospital of Jiaxing University , Jiaxing 314000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Affiliated Women and Children 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Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Mei","sequence":"additional","affiliation":[{"name":"Postgraduate training base Alliance of Wenzhou Medical University, Wenzhou Medical University , Wenzhou 325035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Postgraduate training base Alliance of Wenzhou Medical University, Wenzhou Medical University , Wenzhou 325035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7680-616X","authenticated-orcid":false,"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute 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