{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:43:31Z","timestamp":1790610211596,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81625006"],"award-info":[{"award-number":["81625006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31820103005"],"award-info":[{"award-number":["31820103005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000692"],"award-info":[{"award-number":["32000692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Province Natural Science Foundation of China","award":["LZ24C090003"],"award-info":[{"award-number":["LZ24C090003"]}]},{"name":"Zhejiang Province Natural Science Foundation of China","award":["LY21C090003"],"award-info":[{"award-number":["LY21C090003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The cerebellum is heavily connected with other brain regions, sub-serving not only motor but also nonmotor functions. Genetic mutations leading to cerebellar dysfunction are associated with mental diseases, but cerebellar outputs have not been systematically studied in this context. Here, we present three dimensional distributions of 50,168 target neurons of cerebellar nuclei (CN) from wild-type mice and Nlgn3R451C mutant mice, a mouse model for autism. Our results derived from 36 target nuclei show that the projections from CN to thalamus, midbrain and brainstem are differentially affected by Nlgn3R451C mutation. Importantly, Nlgn3R451C mutation altered the innervation power of CN\u2192zona incerta (ZI) pathway, and chemogenetic inhibition of a neuronal subpopulation in the ZI that receives inputs from the CN rescues social defects in Nlgn3R451C mice. Our study highlights potential role of cerebellar outputs in the pathogenesis of autism and provides potential new therapeutic strategy for this disease.<\/jats:p>","DOI":"10.1093\/procel\/pwae040","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T08:26:24Z","timestamp":1722068784000},"page":"872-888","source":"Crossref","is-referenced-by-count":6,"title":["Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-249X","authenticated-orcid":false,"given":"Xin-Yu","family":"Cai","sequence":"first","affiliation":[{"name":"Center for Brain Health, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University , Yiwu 322000 ,","place":["China"]},{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-7220","authenticated-orcid":false,"given":"Xin-Tai","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, College of Life and Environmental Sciences, Hangzhou Normal University , Hangzhou 311121 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8282-7901","authenticated-orcid":false,"given":"Jing-Wen","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Brain Health, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University , Yiwu 322000 ,","place":["China"]},{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Lab , Hangzhou 311500 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Developmental Genes and Human Disease of the Ministry of Education, School of Life Science and Technology, Southeast University , Nanjing 210096 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-1393","authenticated-orcid":false,"given":"Martijn","family":"Schonewille","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Erasmus University Medical Center , 3000 CA Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-8187","authenticated-orcid":false,"given":"Chris","family":"De Zeeuw","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Erasmus University Medical Center , 3000 CA Rotterdam ,","place":["The Netherlands"]},{"name":"The Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts & Science , 1105 BA Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-7945","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-5328","authenticated-orcid":false,"given":"Ying","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Brain Health, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang 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