{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:33:58Z","timestamp":1792175638335,"version":"4.4.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":232,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506400"],"award-info":[{"award-number":["2023YFC2506400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404100"],"award-info":[{"award-number":["2023YFC3404100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404101"],"award-info":[{"award-number":["2023YFC3404101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225702"],"award-info":[{"award-number":["22225702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82325042"],"award-info":[{"award-number":["82325042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203860"],"award-info":[{"award-number":["82203860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072916"],"award-info":[{"award-number":["82072916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171434"],"award-info":[{"award-number":["32171434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577093"],"award-info":[{"award-number":["22577093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1800400"],"award-info":[{"award-number":["2023YFA1800400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["22XD1420900"],"award-info":[{"award-number":["22XD1420900"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-Level Local Universities in Shanghai","doi-asserted-by":"publisher","award":["SHSMU-ZDCX20212700"],"award-info":[{"award-number":["SHSMU-ZDCX20212700"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Education Commission Scientific Research Innovation Project","award":["2023-05-50"],"award-info":[{"award-number":["2023-05-50"]}]},{"name":"Wu Jieping Medical Foundation Research Project","award":["32067502023-18-29"],"award-info":[{"award-number":["32067502023-18-29"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer is the most frequently diagnosed cancer, with metastasis accounting for the majority of cancer-related deaths. The mechanisms of early-stage breast cancer metastasis to regional immune sites like lymph nodes remain elusive. Here, we performed an in-depth proteomic and phosphoproteomic analyses of a substantial series of breast cancer samples, alongside genomic and transcriptomic evaluations. This cohort encompasses 195 specimens: 65 primary breast tumors, their corresponding normal tissues, and metastatic axillary lymph nodes. We offer an overview of the molecular alterations at the transcriptomic, proteomic, and phosphoproteomic levels during lymph node metastasis. Notably, the findings indicate that regional lymph node metastasis is primarily influenced by proteomic and phosphoproteomic alterations, rather than genomic or transcriptomic changes. We found that ANGPTL4 and HMGB1 could serve as biomarkers of lymph node metastasis. Data analysis and cell experiments involving silencing of the alternative splicing (AS) factor HNRNPU demonstrated that AS plays a significant role in modulating protein expression, phosphorylation profiles, and cell proliferation. The key phosphorylation sites, including MARCKSL1-S104 and FKBP15-S320, as well as the upstream kinase PRKCB, were identified as playing crucial roles in breast cancer lymph node metastasis. Targeted intervention of the kinase PRKCB resulted in effectively suppressing the proliferation and metastasis of breast cancer tumor cells. Immune profiling analysis and experimental validation of breast cancer cell co-cultured with CD8+ T cell reveals correlations between phosphorylation of MARCKSL1-S104 and FKBP15-S320 with immune checkpoint PD-L1 expression, and their impact on tumor cell apoptosis, suggesting a potential mechanism of immune evasion in metastasis. This study systematically characterizes the molecular landscape and features of primary breast tumors and their matched metastatic lymph nodes. These insights enhance our understanding of early-stage breast cancer metastasis and may pave the way for improved diagnostic tools and targeted therapeutic strategies.<\/jats:p>","DOI":"10.1093\/procel\/pwag002","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T12:33:43Z","timestamp":1768048423000},"page":"821-839","source":"Crossref","is-referenced-by-count":2,"title":["Multi-omics analysis reveals comprehensive aberrant protein and phosphorylation characteristics in breast cancer and paired metastatic lymph nodes"],"prefix":"10.1093","volume":"17","author":[{"given":"Linhui","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]},{"name":"Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People\u2019s Hospital, and Cancer Center, School of Medicine, Tongji University , Shanghai 200434,","place":["China"]},{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Cui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People\u2019s Hospital, and Cancer Center, School of Medicine, Tongji University , Shanghai 200434,","place":["China"]},{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan, 528400,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]},{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of General Surgery, Shenzhen People\u2019s Hospital, The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology , Shenzhen 518020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University , Shanghai 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-9653","authenticated-orcid":false,"given":"Minjia","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","place":["China"]},{"name":"Department of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University , Shanghai 200040,","place":["China"]},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan, 528400,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Da","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]},{"name":"Shanghai Institute of Infectious Disease and Biosecurity, Fudan University , Shanghai 200040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026083121014658500_pwag002-B1","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.2147\/IJN.S424932","article-title":"Anticancer analysis of CD44 targeted cyclosporine loaded thiolated chitosan nanoformulations for sustained release in triple-negative breast cancer","volume":"18","author":"Abduh","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"2026083121014658500_pwag002-B2","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jamaoncol.2018.7147","article-title":"Current landscape of immunotherapy in breast cancer: a review","volume":"5","author":"Adams","year":"2019","journal-title":"JAMA Oncol"},{"key":"2026083121014658500_pwag002-B3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","article-title":"Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression","volume":"17","author":"Becht","year":"2016","journal-title":"Genome Biol"},{"key":"2026083121014658500_pwag002-B4","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026083121014658500_pwag002-B5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","author":"Cancer Genome Atlas","year":"2012","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.172366","article-title":"Multiomics of HER2-low triple-negative breast cancer identifies a receptor tyrosine kinase-relevant subgroup with therapeutic prospects","volume":"8","author":"Chen","year":"2023","journal-title":"JCI Insight"},{"key":"2026083121014658500_pwag002-B7","doi-asserted-by":"crossref","first-page":"216635","DOI":"10.1016\/j.canlet.2024.216635","article-title":"A novel antagonist of the CCL5\/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation","volume":"583","author":"Chen","year":"2024","journal-title":"Cancer Lett"},{"key":"2026083121014658500_pwag002-B8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cac2.12387","article-title":"Resistance to antibody-drug conjugates in breast cancer: mechanisms and solutions","volume":"43","author":"Chen","year":"2023","journal-title":"Cancer Commun (Lond)"},{"key":"2026083121014658500_pwag002-B9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature18270","article-title":"Defining the consequences of genetic variation on a proteome-wide scale","volume":"534","author":"Chick","year":"2016","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B10","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/annonc\/mdv221","article-title":"Tailoring therapies\u2014improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015","volume":"26","author":"Coates","year":"2015","journal-title":"Ann Oncol"},{"key":"2026083121014658500_pwag002-B11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/annonc\/mdz036","article-title":"Genomic alterations in breast cancer: level of evidence for actionability according to ESMO scale for clinical actionability of molecular targets (ESCAT)","volume":"30","author":"Condorelli","year":"2019","journal-title":"Ann Oncol"},{"key":"2026083121014658500_pwag002-B12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B13","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/s43018-024-00820-2","article-title":"Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers","volume":"5","author":"Dong","year":"2024","journal-title":"Nat Cancer"},{"key":"2026083121014658500_pwag002-B14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41420-024-02091-3","article-title":"Long noncoding RNA profiling unveils LINC00960 as unfavorable prognostic biomarker promoting triple negative breast cancer progression","volume":"10","author":"Elango","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026083121014658500_pwag002-B15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.molp.2018.05.009","article-title":"A phytophthora capsici RXLR effector targets and inhibits a plant PPIase to suppress endoplasmic reticulum-mediated immunity","volume":"11","author":"Fan","year":"2018","journal-title":"Mol Plant"},{"key":"2026083121014658500_pwag002-B16","first-page":"524","article-title":"Breast cancer statistics, 2022","volume":"72","author":"Giaquinto","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"2026083121014658500_pwag002-B17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2020.06.013","article-title":"Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma","volume":"182","author":"Gillette","year":"2020","journal-title":"Cell"},{"key":"2026083121014658500_pwag002-B18","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0140-6736(16)31392-7","article-title":"The global burden of women\u2019s cancers: a grand challenge in global health","volume":"389","author":"Ginsburg","year":"2017","journal-title":"Lancet"},{"key":"2026083121014658500_pwag002-B19","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1038\/s41467-024-51232-w","article-title":"Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle","volume":"15","author":"Guo","year":"2024","journal-title":"Nat Commun"},{"key":"2026083121014658500_pwag002-B20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/BJ20111761","article-title":"Recruitment of the endosomal WASH complex is mediated by the extended \u2018tail\u2019 of Fam21 binding to the retromer protein Vps35","volume":"442","author":"Harbour","year":"2012","journal-title":"Biochem J"},{"key":"2026083121014658500_pwag002-B21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41422-023-00794-3","article-title":"H3K4me2\/3 modulate the stability of RNA polymerase II pausing","volume":"33","author":"Hu","year":"2023","journal-title":"Cell Res"},{"key":"2026083121014658500_pwag002-B22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-023-06834-7","article-title":"Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides","volume":"625","author":"Huang","year":"2024","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2016.12.015","article-title":"Implementing genome-driven oncology","volume":"168","author":"Hyman","year":"2017","journal-title":"Cell"},{"key":"2026083121014658500_pwag002-B24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12943-022-01605-w","article-title":"MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b","volume":"21","author":"Jiang","year":"2022","journal-title":"Mol Cancer"},{"key":"2026083121014658500_pwag002-B25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-019-0987-8","article-title":"Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma","volume":"567","author":"Jiang","year":"2019","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B26","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41467-019-09018-y","article-title":"Breast cancer quantitative proteome and proteogenomic landscape","volume":"10","author":"Johansson","year":"2019","journal-title":"Nat Commun"},{"key":"2026083121014658500_pwag002-B27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-19966-1_1","article-title":"Networks of mRNA processing and alternative splicing regulation in health and disease","volume":"1157","author":"Jordan","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"2026083121014658500_pwag002-B28","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1158\/1078-0432.CCR-23-1242","article-title":"Integrative multi-omic profiling of triple-negative breast cancer for identifying suitable therapies","volume":"30","author":"Jovanovic","year":"2024","journal-title":"Clin Cancer Res"},{"key":"2026083121014658500_pwag002-B29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13058-024-01872-z","article-title":"Genomic \u00adprofiling and comparative analysis of male versus female metastatic breast cancer across subtypes","volume":"26","author":"Kadamkulam Syriac","year":"2024","journal-title":"Breast Cancer Res"},{"key":"2026083121014658500_pwag002-B30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccell.2018.07.001","article-title":"Comprehensive analysis of alternative splicing across tumors from 8,705 patients","volume":"34","author":"Kahles","year":"2018","journal-title":"Cancer Cell"},{"key":"2026083121014658500_pwag002-B31","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1038\/s41467-020-19342-3","article-title":"Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing","volume":"11","author":"Lang","year":"2020","journal-title":"Nat Commun"},{"key":"2026083121014658500_pwag002-B32","doi-asserted-by":"crossref","first-page":"112093","DOI":"10.1016\/j.intimp.2024.112093","article-title":"IFI30 as a key regulator of PDL1 immunotherapy prognosis in breast cancer","volume":"133","author":"Li","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"2026083121014658500_pwag002-B33","doi-asserted-by":"crossref","first-page":"101396","DOI":"10.1016\/j.xcrm.2024.101396","article-title":"Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer","volume":"5","author":"Liu","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026083121014658500_pwag002-B34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.fmre.2023.04.019","article-title":"Dysregulation of circular RNAs in inflammation and cancers","volume":"3","author":"Liu","year":"2023","journal-title":"Fundam Res"},{"key":"2026083121014658500_pwag002-B35","doi-asserted-by":"crossref","first-page":"e2205395","DOI":"10.1002\/advs.202205395","article-title":"Combined single-cell and spatial transcriptomics reveal the metabolic evolvement of breast cancer during early dissemination","volume":"10","author":"Liu","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026083121014658500_pwag002-B36","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1073\/pnas.93.14.6964","article-title":"Molecular characterization of a FKBP-type immunophilin from higher plants","volume":"93","author":"Luan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026083121014658500_pwag002-B37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature18003","article-title":"Proteogenomics connects somatic mutations to signalling in breast cancer","volume":"534","author":"Mertins","year":"2016","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B38","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/jnci\/djz023","article-title":"Genomic, transcriptomic, epigenetic, and immune profiling of mucinous breast cancer","volume":"111","author":"Nguyen","year":"2019","journal-title":"J Natl Cancer Inst"},{"key":"2026083121014658500_pwag002-B39","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1038\/s41467-020-20173-5","article-title":"The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences","volume":"11","author":"Pan","year":"2020","journal-title":"Nat Commun"},{"key":"2026083121014658500_pwag002-B40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.7150\/ijbs.6.163","article-title":"The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis","volume":"6","author":"Pan","year":"2010","journal-title":"Int J Biol Sci"},{"key":"2026083121014658500_pwag002-B41","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B42","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2024.01.027","article-title":"Pan-cancer proteogenomics characterization of tumor immunity","volume":"187","author":"Petralia","year":"2024","journal-title":"Cell"},{"key":"2026083121014658500_pwag002-B43","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.cell.2022.04.019","article-title":"Lymph node colonization induces tumor-immune tolerance to promote distant metastasis","volume":"185","author":"Reticker-Flynn","year":"2022","journal-title":"Cell"},{"key":"2026083121014658500_pwag002-B44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"2026083121014658500_pwag002-B45","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026083121014658500_pwag002-B46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1200\/JCO.2014.57.0572","article-title":"Impact of the addition of carboplatin and\/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (alliance)","volume":"33","author":"Sikov","year":"2015","journal-title":"J Clin Oncol"},{"key":"2026083121014658500_pwag002-B47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.breast.2016.10.005","article-title":"Improved survival in metastatic breast cancer 1985-2016","volume":"31","author":"Sundquist","year":"2017","journal-title":"Breast"},{"key":"2026083121014658500_pwag002-B48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.trecan.2022.06.003","article-title":"Lymph node metastasis fuels systemic disease","volume":"8","author":"Ventre","year":"2022","journal-title":"Trends Cancer"},{"key":"2026083121014658500_pwag002-B49","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.yexcr.2008.12.004","article-title":"WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics","volume":"315","author":"Viklund","year":"2009","journal-title":"Exp Cell Res"},{"key":"2026083121014658500_pwag002-B50","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00384-008-0527-8","article-title":"Identification of a new WASP and FKBP-like (WAFL) protein in inflammatory bowel disease: a potential marker gene for ulcerative colitis","volume":"23","author":"Viklund","year":"2008","journal-title":"Int J Colorectal Dis"},{"key":"2026083121014658500_pwag002-B51","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.tplants.2018.09.004","article-title":"Protein language: post-translational modifications talking to each other","volume":"23","author":"Vu","year":"2018","journal-title":"Trends Plant Sci"},{"key":"2026083121014658500_pwag002-B52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41392-022-01098-5","article-title":"Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026083121014658500_pwag002-B53","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.4161\/onci.22475","article-title":"The IRF family of transcription factors: inception, impact and implications in oncogenesis","volume":"1","author":"Yanai","year":"2012","journal-title":"Oncoimmunology"},{"key":"2026083121014658500_pwag002-B54","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1038\/s41401-022-01017-y","article-title":"Proteomic characterization of post-translational modifications in drug discovery","volume":"43","author":"Zhai","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"2026083121014658500_pwag002-B55","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb2522","article-title":"USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-beta type I receptor","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat Cell Biol"},{"key":"2026083121014658500_pwag002-B56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2018.10.030","article-title":"OTUB2 promotes cancer metastasis via Hippo-Independent activation of YAP and TAZ","volume":"73","author":"Zhang","year":"2019","journal-title":"Mol Cell"},{"key":"2026083121014658500_pwag002-B57","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1038\/s41388-022-02349-z","article-title":"NSrp70 suppresses metastasis in triple-negative breast cancer by modulating numb\/T\u03b2R1\/EMT axis","volume":"41","author":"Zhao","year":"2022","journal-title":"Oncogene"},{"key":"2026083121014658500_pwag002-B58","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1002\/cam4.5079","article-title":"MARCKSL1 interacted with F-actin to promote esophageal squamous cell carcinoma mobility by modulating the formation of invadopodia","volume":"12","author":"Zhao","year":"2023","journal-title":"Cancer Med"}],"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag002\/66382268\/pwag002.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/article-pdf\/17\/9\/821\/70880214\/pwag002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/article-pdf\/17\/9\/821\/70880214\/pwag002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:02:18Z","timestamp":1788224538000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/17\/9\/821\/8423503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,1,12]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag002","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,1,12]]}}}