{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:08:07Z","timestamp":1788808087830,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China","award":["JYB2025XDXM704"],"award-info":[{"award-number":["JYB2025XDXM704"]}]},{"name":"Joint Research Foundation of Gansu Province","award":["24JRRA805"],"award-info":[{"award-number":["24JRRA805"]}]},{"name":"State Key R&D Program of China","award":["2024YFA1306500"],"award-info":[{"award-number":["2024YFA1306500"]}]},{"name":"State Key R&D Program of China","award":["2025YFD1800705"],"award-info":[{"award-number":["2025YFD1800705"]}]},{"name":"Major Science and Technology Project of Gansu Province","award":["22ZD6NA001"],"award-info":[{"award-number":["22ZD6NA001"]}]},{"name":"Fundamental Research Innovation Group Project of Gansu Province","award":["23JRRA561"],"award-info":[{"award-number":["23JRRA561"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>African swine fever virus (ASFV) is a lethal pathogen that triggers uncontrolled cytokine storms and severe immunopathology. However, the viral factors responsible for systemic inflammation remain unclear. Here, we show that the ASFV-encoded proteins MGF_110-3L and MGF_110-4L are secreted via the conventional ER-Golgi pathway. Single-cell RNA sequencing of porcine PBMCs revealed that MGF_110-3L preferentially activates inflammatory responses in monocytic cells. Mechanistically, both proteins bind Toll-like receptor 2 (TLR2) and signal through TLR2\/TLR1 and TLR2\/TLR6 heterocomplexes, with the co-receptor CD14 enhancing ligand recognition and signal amplification. These interactions activate MyD88-dependent NF-\u03baB signaling, leading to robust induction of proinflammatory cytokines. ASFV strains lacking either MGF_110-3L or MGF_110-4L cause attenuated cytokine responses in vitro and impaired inflammatory pathology in pigs. Together, these findings establish MGF_110-3L and MGF_110-4L as secreted virulence factors that subvert innate immune recognition and drive lethal inflammation, highlighting their potential as targets for antiviral and vaccine development.<\/jats:p>","DOI":"10.1093\/procel\/pwag047","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:24:02Z","timestamp":1783941842000},"source":"Crossref","is-referenced-by-count":0,"title":["African swine fever virus MGF_110-3L and MGF_110-4L signal TLR2-mediated lethal inflammation"],"prefix":"10.1093","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou 730000,","place":["China"]},{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou 730000,","place":["China"]},{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Huan","family":"Shao","sequence":"additional","affiliation":[{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]},{"name":"National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University , Guangzhou 510642,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Pan","family":"Hou","sequence":"additional","affiliation":[{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Wang","family":"Shi","sequence":"additional","affiliation":[{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences Gansu Province Research Center for Basic Disciplines of Pathogen Biology, , Lanzhou 730046,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural 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