{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:24:48Z","timestamp":1792095888520,"version":"4.4.0"},"reference-count":342,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2024YFA1802800"],"award-info":[{"award-number":["2024YFA1802800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","award":["2024YFA1306101"],"award-info":[{"award-number":["2024YFA1306101"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Yunnan Provincial Science and Technology Project at Southwest United Graduate School","award":["202302AO370004"],"award-info":[{"award-number":["202302AO370004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371232"],"award-info":[{"award-number":["32371232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92357302"],"award-info":[{"award-number":["92357302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Fundamental Research","award":["202301BF070001-023"],"award-info":[{"award-number":["202301BF070001-023"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761235"],"award-info":[{"award-number":["2024M761235"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u201cCaiyun Postdoctoral\u201d Innovation program of Yunnan Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid droplets (LDs) are intracellular organelles that dynamically regulate lipid and energy homeostasis, mediate hormone production, produce inflammation signaling, while also participating in numerous biological processes and activities. Dysregulation of LD homeostasis is linked to various diseases, such as lipodystrophy, obesity, type 2 diabetes, cardiovascular diseases, metabolic dysfunction-associated steatotic liver disease, neuronal diseases, and among others. The core of LDs consists of neutral lipids, including triacylglycerol, cholesteryl esters, and retinyl esters, which are encircled by a monolayer of phospholipid membrane decorated with a subset of LD proteins, both resident as well as dynamic, that vary in different cells, tissues, organs, and organisms. Over the past two decades, together with technological advances, significant achievements have been made in understanding LD biology, including their life cycle: such as biogenesis, growth\/expansion, fusion, and degradation, as well as their diversity and heterogeneity, under both physiological and pathological conditions. In this review, we summarize the current knowledge and methodologies of LD biology in animal cells, and also provide guiding questions, hopefully bringing new directions for future study of LDs and for potential therapeutic treatments for LD-related human diseases.<\/jats:p>","DOI":"10.1093\/procel\/pwag048","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:49:02Z","timestamp":1784202542000},"source":"Crossref","is-referenced-by-count":2,"title":["Lipid droplets, an enigmatic organelle under the spotlight"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-9465","authenticated-orcid":false,"given":"Lin","family":"Fu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University , Kunming 650500,","place":["China"]},{"name":"Key Laboratory of Tumor Immunological Prevention and Treatment in Yunnan Province, Yan\u2019an Hospital Affiliated to Kunming Medical University , Kunming 650051,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3950-7606","authenticated-orcid":false,"given":"Hongsheng","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University , Kunming 650500,","place":["China"]},{"name":"Southwest United Graduate School , Kunming 650092,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1861-6494","authenticated-orcid":false,"given":"Ruhong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunological Prevention and Treatment in Yunnan Province, Yan\u2019an Hospital Affiliated to Kunming Medical University , Kunming 650051,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-9004","authenticated-orcid":false,"given":"Pingsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-5478","authenticated-orcid":false,"given":"Bin","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University , Kunming 650500,","place":["China"]},{"name":"Southwest United Graduate School , Kunming 650092,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026090913511021400_pwag048-B1","doi-asserted-by":"crossref","first-page":"102466","DOI":"10.1016\/j.ceb.2025.102466","article-title":"Moving the fat: emerging roles of rab GTPases in the regulation of lipid droplet contact sites","volume":"93","author":"Alonso-Bivou","year":"2025","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.devcel.2024.01.014","article-title":"LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced lipophagy in yeast","volume":"59","author":"\u00c1lvarez-Guerra","year":"2024","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer\u2019s 1907 paper, \u201cuber eine eigenartige erkankung der hirnrinde\u201d","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin Anat"},{"key":"2026090913511021400_pwag048-B4","doi-asserted-by":"crossref","first-page":"24480","DOI":"10.1038\/s41598-025-07934-2","article-title":"Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites","volume":"15","author":"Amado","year":"2025","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/ijms24021173","article-title":"Application of Caenorhabditis elegans in lipid metabolism research","volume":"24","author":"An","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026090913511021400_pwag048-B6","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1242\/jcs.02941","article-title":"PLD1 and ERK2 regulate cytosolic lipid droplet formation","volume":"119","author":"Andersson","year":"2006","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B7","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1091\/mbc.e11-10-0847","article-title":"Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes","volume":"23","author":"Ariotti","year":"2012","journal-title":"Mol Biol Cell"},{"key":"2026090913511021400_pwag048-B8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of Drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"2026090913511021400_pwag048-B9","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.bbamcr.2017.04.001","article-title":"Function of lipid droplet-organelle interactions in lipid homeostasis","volume":"1864","author":"Barbosa","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2026090913511021400_pwag048-B10","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1111\/febs.15307","article-title":"New kid on the block: lipid droplets in the nucleus","volume":"287","author":"Barbosa","year":"2020","journal-title":"Febs J"},{"key":"2026090913511021400_pwag048-B11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ceb.2017.02.002","article-title":"Lipid droplet growth: regulation of a dynamic organelle","volume":"47","author":"Barneda","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B12","doi-asserted-by":"crossref","first-page":"e07485","DOI":"10.7554\/eLife.07485","article-title":"The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix","volume":"4","author":"Barneda","year":"2015","journal-title":"Elife"},{"key":"2026090913511021400_pwag048-B13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1194\/jlr.M600413-JLR200","article-title":"Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic","volume":"48","author":"Bartz","year":"2007","journal-title":"J Lipid Res"},{"key":"2026090913511021400_pwag048-B14","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1091\/mbc.e06-09-0869","article-title":"Evidence that Mono-ADP-ribosylation of CtBP1\/BARS regulates lipid storage","volume":"18","author":"Bartz","year":"2007","journal-title":"Mol Biol Cell"},{"key":"2026090913511021400_pwag048-B15","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1021\/pr070158j","article-title":"Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation","volume":"6","author":"Bartz","year":"2007","journal-title":"J Proteome Res"},{"key":"2026090913511021400_pwag048-B16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"2026090913511021400_pwag048-B17","doi-asserted-by":"crossref","first-page":"e202006111","DOI":"10.1083\/jcb.202006111","article-title":"FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis","volume":"219","author":"Becuwe","year":"2020","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2009.11.3\/mbelanger","article-title":"The role of astroglia in neuroprotection","volume":"11","author":"B\u00e9langer","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"key":"2026090913511021400_pwag048-B19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.devcel.2017.05.012","article-title":"ER membrane phospholipids and surface tension control cellular lipid droplet formation","volume":"41","author":"Ben M\u2019barek","year":"2017","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cmet.2019.02.011","article-title":"Mitochondria bound to lipid droplets: where mitochondrial dynamics regulate lipid storage and utilization","volume":"29","author":"Benador","year":"2019","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cmet.2018.03.003","article-title":"Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion","volume":"27","author":"Benador","year":"2018","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41580-022-00506-6","article-title":"Mechanisms of mitochondrial respiratory adaptation","volume":"23","author":"Bennett","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090913511021400_pwag048-B23","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.bbalip.2017.06.006","article-title":"Establishing the lipid droplet proteome: mechanisms of lipid droplet protein targeting and degradation","volume":"1862","author":"Bersuker","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2026090913511021400_pwag048-B24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.devcel.2017.11.020","article-title":"A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes","volume":"44","author":"Bersuker","year":"2018","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B25","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41467-025-57405-5","article-title":"Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites","volume":"16","author":"Bezawork-Geleta","year":"2025","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B26","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1242\/jcs.101329","article-title":"Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization","volume":"125","author":"Bi","year":"2012","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1083\/jcb.200511125","article-title":"An intimate collaboration between peroxisomes and lipid bodies","volume":"173","author":"Binns","year":"2006","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B28","doi-asserted-by":"crossref","first-page":"102665","DOI":"10.1016\/j.ceb.2026.102665","article-title":"I did it my way: the origins of lipid droplet heterogeneity","volume":"101","author":"Bohnert","year":"2026","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B29","doi-asserted-by":"crossref","first-page":"103022","DOI":"10.1016\/j.jbc.2023.103022","article-title":"Fitm2 is required for ER homeostasis and normal function of murine liver","volume":"299","author":"Bond","year":"2023","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B30","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay8085","article-title":"Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense","volume":"370","author":"Bosch","year":"2020","journal-title":"Science"},{"key":"2026090913511021400_pwag048-B31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.yexcr.2015.06.001","article-title":"Models of lipid droplets growth and fission in adipocyte cells","volume":"336","author":"Boschi","year":"2015","journal-title":"Exp Cell Res"},{"key":"2026090913511021400_pwag048-B32","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/ncb1648","article-title":"SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity","volume":"9","author":"Bostr\u00f6m","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B33","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/01.ATV.0000179676.41064.d4","article-title":"Cytosolic lipid droplets increase in size by microtubule-dependent complex formation","volume":"25","author":"Bostr\u00f6m","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026090913511021400_pwag048-B34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BC20110024","article-title":"The proteome of cytosolic lipid droplets isolated from differentiated caco-2\/TC7 enterocytes reveals cell-specific characteristics","volume":"103","author":"Bouchoux","year":"2011","journal-title":"Biol Cell"},{"key":"2026090913511021400_pwag048-B35","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nbt.4201","article-title":"Efficient proximity labeling in living cells and organisms with TurboID","volume":"36","author":"Branon","year":"2018","journal-title":"Nat Biotechnol"},{"key":"2026090913511021400_pwag048-B36","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1194\/jlr.R700014-JLR200","article-title":"Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis","volume":"48","author":"Brasaemle","year":"2007","journal-title":"J Lipid Res"},{"key":"2026090913511021400_pwag048-B37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2011.09.002","article-title":"DisseCCTing phospholipid function in lipid droplet dynamics","volume":"14","author":"Brasaemle","year":"2011","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B38","doi-asserted-by":"crossref","first-page":"46835","DOI":"10.1074\/jbc.M409340200","article-title":"Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes","volume":"279","author":"Brasaemle","year":"2004","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B39","doi-asserted-by":"crossref","first-page":"13018","DOI":"10.1073\/pnas.95.22.13018","article-title":"Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis","volume":"95","author":"Cases","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B40","doi-asserted-by":"crossref","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B41","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.cub.2006.07.062","article-title":"The lipid-droplet proteome reveals that droplets are a protein-storage depot","volume":"16","author":"Cermelli","year":"2006","journal-title":"Curr Biol"},{"key":"2026090913511021400_pwag048-B42","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.bbamcr.2013.05.023","article-title":"Splicing and beyond: the many faces of the Prp19 complex","volume":"1833","author":"Chanarat","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B43","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1083\/jcb.201902061","article-title":"Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III","volume":"218","author":"Chang","year":"2019","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B44","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/nar\/gkt932","article-title":"Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630","volume":"42","author":"Chen","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026090913511021400_pwag048-B45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41419-025-07957-7","article-title":"AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria","volume":"16","author":"Chen","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026090913511021400_pwag048-B46","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.tem.2024.10.006","article-title":"Lipid droplets as cell fate determinants in skeletal muscle","volume":"36","author":"Chen","year":"2025","journal-title":"Trends Endocrinol Metab"},{"key":"2026090913511021400_pwag048-B47","first-page":"25152564221125613","article-title":"VPS13A and VPS13C influence lipid droplet abundance","volume":"5","author":"Chen","year":"2022","journal-title":"Contact (Thousand Oaks)"},{"key":"2026090913511021400_pwag048-B48","doi-asserted-by":"crossref","first-page":"e201907183","DOI":"10.1083\/jcb.201907183","article-title":"FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins","volume":"220","author":"Chen","year":"2021","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B49","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.1073\/pnas.1919528117","article-title":"Split-TurboID enables contact-dependent proximity labeling in cells","volume":"117","author":"Cho","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B50","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1038\/s41596-020-0399-0","article-title":"Proximity labeling in mammalian cells with TurboID and split-TurboID","volume":"15","author":"Cho","year":"2020","journal-title":"Nat Protoc"},{"key":"2026090913511021400_pwag048-B51","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1074\/jbc.M608042200","article-title":"Identification of mouse Prp19p as a lipid droplet-associated protein and its possible involvement in the biogenesis of lipid droplets","volume":"282","author":"Cho","year":"2007","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.devcel.2019.05.003","article-title":"Membrane asymmetry imposes directionality on lipid droplet emergence from the ER","volume":"50","author":"Chorlay","year":"2019","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bpj.2017.12.014","article-title":"An asymmetry in monolayer tension regulates lipid droplet budding direction","volume":"114","author":"Chorlay","year":"2018","journal-title":"Biophys J"},{"key":"2026090913511021400_pwag048-B54","doi-asserted-by":"crossref","first-page":"e201907099","DOI":"10.1083\/jcb.201907099","article-title":"Neutral lipids regulate amphipathic helix affinity for model lipid droplets","volume":"219","author":"Chorlay","year":"2020","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B55","doi-asserted-by":"crossref","first-page":"e201910177","DOI":"10.1083\/jcb.201910177","article-title":"Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis","volume":"219","author":"Choudhary","year":"2020","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B56","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cub.2018.02.020","article-title":"Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature","volume":"28","author":"Choudhary","year":"2018","journal-title":"Curr Biol"},{"key":"2026090913511021400_pwag048-B57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1083\/jcb.201505067","article-title":"A conserved family of proteins facilitates nascent lipid droplet budding from the ER","volume":"211","author":"Choudhary","year":"2015","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B58","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1194\/jlr.M009498","article-title":"Identification of the lipid droplet targeting domain of the cidea protein","volume":"51","author":"Christianson","year":"2010","journal-title":"J Lipid Res"},{"key":"2026090913511021400_pwag048-B59","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.devcel.2019.10.006","article-title":"LDAF1 and seipin form a lipid droplet assembly complex","volume":"51","author":"Chung","year":"2019","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B60","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tem.2016.06.003","article-title":"Regulation and functions of autophagic lipolysis","volume":"27","author":"Cingolani","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"2026090913511021400_pwag048-B61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13024-021-00473-0","article-title":"Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer\u2019s disease","volume":"16","author":"Claes","year":"2021","journal-title":"Mol Neurodegener"},{"key":"2026090913511021400_pwag048-B62","doi-asserted-by":"crossref","first-page":"158762","DOI":"10.1016\/j.bbalip.2020.158762","article-title":"The \u201cdiscovery\u201d of lipid droplets: a brief history of organelles hidden in plain sight","volume":"1865","author":"Coleman","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2026090913511021400_pwag048-B63","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1021\/jacs.7b12817","article-title":"Ultrabright and fluorogenic probes for multicolor imaging and tracking of lipid droplets in cells and tissues","volume":"140","author":"Collot","year":"2018","journal-title":"J Am Chem Soc"},{"key":"2026090913511021400_pwag048-B64","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258819","article-title":"Lipid droplets form a network interconnected by the endoplasmic reticulum through which their proteins equilibrate","volume":"135","author":"Cottier","year":"2022","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B65","doi-asserted-by":"crossref","first-page":"618322","DOI":"10.3389\/fcell.2020.618322","article-title":"Two types of contact between lipid droplets and mitochondria","volume":"8","author":"Cui","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026090913511021400_pwag048-B66","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s13238-019-00661-1","article-title":"Lipid droplets and mitochondria are anchored during brown adipocyte differentiation","volume":"10","author":"Cui","year":"2019","journal-title":"Protein Cell"},{"key":"2026090913511021400_pwag048-B67","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbalip.2006.07.001","article-title":"Synthesis, storage and degradation of neutral lipids in yeast","volume":"1771","author":"Czabany","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B68","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1073\/pnas.120067297","article-title":"Phospholipid: diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants","volume":"97","author":"Dahlqvist","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B69","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1016\/j.molcel.2024.10.022","article-title":"VPS4A is the selective receptor for lipophagy in mice and humans","volume":"84","author":"Das","year":"2024","journal-title":"Mol Cell"},{"key":"2026090913511021400_pwag048-B70","doi-asserted-by":"crossref","first-page":"28343","DOI":"10.1074\/jbc.M111.254227","article-title":"p53-inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation","volume":"286","author":"Deisenroth","year":"2011","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B71","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1021\/acs.analchem.5c05923","article-title":"Rational construction of a lipid droplet-targeted redox-responsive ratiometric probe for screening of antioxidant drugs and its application in Parkinson\u2019s disease","volume":"98","author":"Deng","year":"2026","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B72","doi-asserted-by":"crossref","first-page":"127593","DOI":"10.1016\/j.saa.2026.127593","article-title":"Application of a near-infrared fluorescent probe with dual-targeting capability toward lipid droplets and mitochondria in imaging of liver cirrhosis and tumors","volume":"353","author":"Deng","year":"2026","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"2026090913511021400_pwag048-B73","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.semcdb.2020.03.004","article-title":"Mechanisms of protein targeting to lipid droplets: a unified cell biological and biophysical perspective","volume":"108","author":"Dhiman","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"2026090913511021400_pwag048-B74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nprot.2012.142","article-title":"Isolating lipid droplets from multiple species","volume":"8","author":"Ding","year":"2013","journal-title":"Nat Protoc"},{"key":"2026090913511021400_pwag048-B75","first-page":"1","article-title":"Lipid droplet contacts with autophagosomes, lysosomes, and other degradative vesicles","volume":"3","author":"Drizyte-Miller","year":"2020","journal-title":"Contact (Thousand Oaks)"},{"key":"2026090913511021400_pwag048-B76","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/1873-3468.14779","article-title":"The role of lipid droplet associated proteins in inherited human disorders","volume":"598","author":"Duan","year":"2024","journal-title":"FEBS Lett"},{"key":"2026090913511021400_pwag048-B77","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41467-023-36375-6","article-title":"Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols","volume":"14","author":"Dumesnil","year":"2023","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B78","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.201704122","article-title":"Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation","volume":"217","author":"Eisenberg-Bord","year":"2018","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B79","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/s41594-025-01689-0","article-title":"ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth","volume":"32","author":"Elhan","year":"2025","journal-title":"Nat Struct Mol Biol"},{"key":"2026090913511021400_pwag048-B80","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1080\/15548627.2026.2645161","article-title":"ATG2A connects lipid droplets and the ER to regulate lipid storage","volume":"22","author":"Elhan","year":"2026","journal-title":"Autophagy"},{"key":"2026090913511021400_pwag048-B81","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.223016","article-title":"An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1","volume":"132","author":"Exner","year":"2019","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B82","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.3390\/ijms25136878","article-title":"Lipid droplet-mitochondria contacts in health and disease","volume":"25","author":"Fan","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026090913511021400_pwag048-B83","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/cells8020182","article-title":"Apolipoprotein E4 alters astrocyte fatty acid metabolism and lipid droplet formation","volume":"8","author":"Farmer","year":"2019","journal-title":"Cells"},{"key":"2026090913511021400_pwag048-B84","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","article-title":"Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast","volume":"180","author":"Fei","year":"2008","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B85","doi-asserted-by":"crossref","first-page":"e1002201","DOI":"10.1371\/journal.pgen.1002201","article-title":"A role for phosphatidic acid in the formation of \"supersized\" lipid droplets","volume":"7","author":"Fei","year":"2011","journal-title":"PLoS Genet"},{"key":"2026090913511021400_pwag048-B86","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bbrc.2011.10.091","article-title":"The size and phospholipid composition of lipid droplets can influence their proteome","volume":"415","author":"Fei","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2026090913511021400_pwag048-B87","doi-asserted-by":"crossref","first-page":"344603","DOI":"10.1016\/j.aca.2025.344603","article-title":"A pyridinemalononitrile-based polarity-responsive fluorescent probe for lipid droplet dynamics tracking and nonalcoholic fatty liver disease diagnosis","volume":"1376","author":"Feng","year":"2025","journal-title":"Anal Chim Acta"},{"key":"2026090913511021400_pwag048-B88","doi-asserted-by":"crossref","first-page":"e202103176","DOI":"10.1083\/jcb.202103176","article-title":"Pex30-like proteins function as adaptors at distinct ER membrane contact sites","volume":"220","author":"Ferreira","year":"2021","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B89","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The m\u00e9nage \u00e0 trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Filali-Mouncef","year":"2022","journal-title":"Autophagy"},{"key":"2026090913511021400_pwag048-B90","doi-asserted-by":"crossref","first-page":"108132","DOI":"10.1016\/j.celrep.2020.108132","article-title":"Cell-type- and brain-region-resolved mouse brain lipidome","volume":"32","author":"Fitzner","year":"2020","journal-title":"Cell Rep"},{"key":"2026090913511021400_pwag048-B91","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(87)90763-X","article-title":"Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules","volume":"49","author":"Franke","year":"1987","journal-title":"Cell"},{"key":"2026090913511021400_pwag048-B92","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.molcel.2019.09.011","article-title":"MIGA2 links mitochondria, the ER, and lipid droplets and promotes de novo lipogenesis in adipocytes","volume":"76","author":"Freyre","year":"2019","journal-title":"Mol Cell"},{"key":"2026090913511021400_pwag048-B93","doi-asserted-by":"crossref","first-page":"102","DOI":"10.52601\/bpr.2024.240007","article-title":"Co-immunoprecipitation for identifying protein-protein interaction on lipid droplets","volume":"10","author":"Fu","year":"2024","journal-title":"Biophys Rep"},{"key":"2026090913511021400_pwag048-B94","doi-asserted-by":"crossref","first-page":"e202311024","DOI":"10.1083\/jcb.202311024","article-title":"LET-767 determines lipid droplet protein targeting and lipid homeostasis","volume":"223","author":"Fu","year":"2024","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B95","doi-asserted-by":"crossref","first-page":"102370","DOI":"10.1016\/j.ceb.2024.102370","article-title":"Nuclear lipid droplet: guardian of nuclear membrane lipid homeostasis?","volume":"88","author":"Fujimoto","year":"2024","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B96","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbamcr.2003.10.018","article-title":"Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7","volume":"1644","author":"Fujimoto","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B97","doi-asserted-by":"crossref","first-page":"e202410013","DOI":"10.1083\/jcb.202410013","article-title":"Any1 is a phospholipid scramblase involved in endosome biogenesis","volume":"224","author":"Gao","year":"2025","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B98","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/ijms21020578","article-title":"Pexophagy: a model for selective autophagy","volume":"21","author":"Germain","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026090913511021400_pwag048-B99","doi-asserted-by":"crossref","first-page":"e2101562118","DOI":"10.1073\/pnas.2101562118","article-title":"A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis","volume":"118","author":"Ghanbarpour","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/ijms26020557","article-title":"Omics approaches to study perilipins and their significant biological role in cardiometabolic disorders","volume":"26","author":"Gianazza","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026090913511021400_pwag048-B101","doi-asserted-by":"crossref","first-page":"25686","DOI":"10.1074\/jbc.M115.676700","article-title":"Postnatal deletion of fat storage-inducing transmembrane protein 2 (FIT2\/FITM2) causes lethal enteropathy","volume":"290","author":"Goh","year":"2015","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B102","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCULATIONAHA.118.033704","article-title":"Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 national heart, lung, and blood institute workshop","volume":"138","author":"Goldberg","year":"2018","journal-title":"Circulation"},{"key":"2026090913511021400_pwag048-B103","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1083\/jcb.201710116","article-title":"Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores","volume":"217","author":"G\u00f3mez-S\u00e1nchez","year":"2018","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B104","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.201104142","article-title":"Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites","volume":"195","author":"Gong","year":"2011","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B105","doi-asserted-by":"crossref","first-page":"e2024058118","DOI":"10.1073\/pnas.2024058118","article-title":"The importance of microlipophagy in liver","volume":"118","author":"Goodman","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B106","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/s41593-024-01740-1","article-title":"Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress","volume":"27","author":"Goodman","year":"2024","journal-title":"Nat Neurosci"},{"key":"2026090913511021400_pwag048-B107","doi-asserted-by":"crossref","first-page":"1422032","DOI":"10.3389\/fcell.2024.1422032","article-title":"FIT2 proteins and lipid droplet emergence, an interplay between phospholipid synthesis, surface tension, and membrane curvature","volume":"12","author":"Graff","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"2026090913511021400_pwag048-B108","doi-asserted-by":"crossref","first-page":"E574","DOI":"10.1152\/ajpendo.00567.2003","article-title":"Seeing the trees in the forest: selective electroporation of adipocytes within adipose tissue","volume":"287","author":"Granneman","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026090913511021400_pwag048-B109","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","article-title":"Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets","volume":"266","author":"Greenberg","year":"1991","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B110","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1073\/pnas.90.24.12035","article-title":"Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes","volume":"90","author":"Greenberg","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B111","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/1873-3468.14792","article-title":"Molecular mechanisms of perilipin protein function in lipid droplet metabolism","volume":"598","author":"Griseti","year":"2024","journal-title":"FEBS Lett"},{"key":"2026090913511021400_pwag048-B112","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/10409238.2014.931337","article-title":"Cytosolic lipid droplets: from mechanisms of fat storage to disease","volume":"49","author":"Gross","year":"2014","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2026090913511021400_pwag048-B113","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1073\/pnas.1110817108","article-title":"Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation","volume":"108","author":"Gross","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B114","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1021\/acs.langmuir.4c00270","article-title":"The role of lipid intrinsic curvature in the droplet interface bilayer","volume":"40","author":"Gudyka","year":"2024","journal-title":"Langmuir"},{"key":"2026090913511021400_pwag048-B115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature06928","article-title":"Functional genomic screen reveals genes involved in lipid-droplet formation and utilization","volume":"453","author":"Guo","year":"2008","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B116","article-title":"LipoID profiles lipid droplet interactions and identifies interorganelle regulators","author":"Guo","year":"2026","journal-title":"Nat Chem Biol"},{"key":"2026090913511021400_pwag048-B117","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/acschemneuro.6c00284","article-title":"Lipid droplet-accumulating microglia as a therapeutic node in neurodegenerative disease","volume":"17","author":"Guo","year":"2026","journal-title":"ACS Chem Neurosci"},{"key":"2026090913511021400_pwag048-B118","doi-asserted-by":"crossref","first-page":"101233","DOI":"10.1016\/j.plipres.2023.101233","article-title":"Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles","volume":"91","author":"Hammoudeh","year":"2023","journal-title":"Prog Lipid Res"},{"key":"2026090913511021400_pwag048-B119","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer\u2019s disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.15252\/embr.201744815","article-title":"Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress","volume":"19","author":"Hariri","year":"2018","journal-title":"EMBO Rep"},{"key":"2026090913511021400_pwag048-B121","doi-asserted-by":"crossref","first-page":"88","DOI":"10.15698\/mic2018.02.614","article-title":"Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase\/phosphotransferase enzymes","volume":"5","author":"Hayes","year":"2017","journal-title":"Microb Cell"},{"key":"2026090913511021400_pwag048-B122","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41593-023-01568-1","article-title":"A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis","volume":"27","author":"Haynes","year":"2024","journal-title":"Nat Neurosci"},{"key":"2026090913511021400_pwag048-B123","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41580-025-00945-x","article-title":"Heterogeneity, dynamics and organelle interactions of lipid droplets","volume":"27","author":"Henne","year":"2026","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090913511021400_pwag048-B124","doi-asserted-by":"crossref","first-page":"e202406019","DOI":"10.1083\/jcb.202406019","article-title":"Lipid droplets: open questions and conceptual advances around a unique organelle","volume":"224","author":"Henne","year":"2025","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.201503088","article-title":"Mdm1\/Snx13 is a novel ER-endolysosomal interorganelle tethering protein","volume":"210","author":"Henne","year":"2015","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B126","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/s42255-022-00706-6","article-title":"mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species","volume":"4","author":"Hosios","year":"2022","journal-title":"Nat Metab"},{"key":"2026090913511021400_pwag048-B127","first-page":"4067","article-title":"Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets","volume":"125","author":"Hsieh","year":"2012","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B128","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1021\/acssensors.6c01055","article-title":"A polarity-sensitive lipid droplet probe reveals a\u03b2 species-dependent lipid droplet remodeling in microglia","volume":"11","author":"Hu","year":"2026","journal-title":"ACS Sens"},{"key":"2026090913511021400_pwag048-B129","doi-asserted-by":"crossref","first-page":"e2307749","DOI":"10.1002\/advs.202307749","article-title":"Mfn2\/Hsc70 complex mediates the formation of mitochondria-lipid droplets membrane contact and regulates myocardial lipid metabolism","volume":"11","author":"Hu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026090913511021400_pwag048-B130","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1080\/15384101.2023.2210335","article-title":"Equal distribution of lipid droplets in daughter cells is regulated by microtubules","volume":"22","author":"Huang","year":"2023","journal-title":"Cell Cycle"},{"key":"2026090913511021400_pwag048-B131","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.cmet.2021.05.006","article-title":"TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis","volume":"33","author":"Huang","year":"2021","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B132","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-astrocyte metabolic coupling protects against Activity-Induced fatty acid toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"key":"2026090913511021400_pwag048-B133","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12944-017-0473-y","article-title":"Perilipins: a diversity of intracellular lipid droplet proteins","volume":"16","author":"Itabe","year":"2017","journal-title":"Lipids Health Dis"},{"key":"2026090913511021400_pwag048-B134","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ceb.2019.03.018","article-title":"Lipid droplet biogenesis","volume":"59","author":"Jackson","year":"2019","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B135","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1242\/jcs.076836","article-title":"Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae","volume":"124","author":"Jacquier","year":"2011","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B136","doi-asserted-by":"crossref","first-page":"e28614","DOI":"10.1371\/journal.pone.0028614","article-title":"FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation","volume":"6","author":"Jambunathan","year":"2011","journal-title":"PLoS One"},{"key":"2026090913511021400_pwag048-B137","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tcb.2006.08.009","article-title":"Biophysical properties of lipids and dynamic membranes","volume":"16","author":"Janmey","year":"2006","journal-title":"Trends Cell Biol"},{"key":"2026090913511021400_pwag048-B138","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1073\/pnas.89.17.7856","article-title":"Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein","volume":"89","author":"Jiang","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B139","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s12276-020-00503-9","article-title":"Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases","volume":"52","author":"Jo","year":"2020","journal-title":"Exp Mol Med"},{"key":"2026090913511021400_pwag048-B140","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/s41467-018-05277-3","article-title":"Lipid droplet and peroxisome biogenesis occur at the same ER subdomains","volume":"9","author":"Joshi","year":"2018","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B141","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1073\/pnas.0708579105","article-title":"Evolutionarily conserved gene family important for fat storage","volume":"105","author":"Kadereit","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B142","doi-asserted-by":"crossref","first-page":"e2200513119","DOI":"10.1073\/pnas.2200513119","article-title":"Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro","volume":"119","author":"Kamerkar","year":"2022","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026090913511021400_pwag048-B143","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s42255-026-01476-1","article-title":"PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis","volume":"8","author":"Kang","year":"2026","journal-title":"Nat Metab"},{"key":"2026090913511021400_pwag048-B144","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1083\/jcb.201305142","article-title":"Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains","volume":"203","author":"Kassan","year":"2013","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B145","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B146","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S002202990001267X","article-title":"Size distribution of fat globules in cow\u2019s milk during milking, measured with a coulter counter","volume":"36","author":"Kernohan","year":"1969","journal-title":"J Dairy Res"},{"key":"2026090913511021400_pwag048-B147","doi-asserted-by":"crossref","first-page":"10642","DOI":"10.1038\/s41467-025-65645-8","article-title":"The luminal domain region of seipin\/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis","volume":"16","author":"Khatri","year":"2025","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B148","doi-asserted-by":"crossref","first-page":"e105047","DOI":"10.1371\/journal.pone.0105047","article-title":"The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid droplets","volume":"9","author":"Khor","year":"2014","journal-title":"PLoS One"},{"key":"2026090913511021400_pwag048-B149","doi-asserted-by":"crossref","first-page":"e1010875","DOI":"10.1371\/journal.pgen.1010875","article-title":"Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis","volume":"19","author":"Kilwein","year":"2023","journal-title":"PLoS Genet"},{"key":"2026090913511021400_pwag048-B150","first-page":"10","article-title":"Lipid droplet motility and organelle contacts","volume":"2","author":"Kilwein","year":"2019","journal-title":"Contact (Thousand Oaks)"},{"key":"2026090913511021400_pwag048-B151","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1021\/acs.analchem.3c05368","article-title":"Dynamic imaging of lipid droplets in cells and tissues by using dioxaborine Barbiturate-Based fluorogenic probes","volume":"96","author":"Kim","year":"2024","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B152","doi-asserted-by":"crossref","first-page":"102342","DOI":"10.1016\/j.ceb.2024.102342","article-title":"Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells","volume":"87","author":"Kim","year":"2024","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B153","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1021\/acs.jpcb.1c01795","article-title":"Stressed lipid droplets: how neutral lipids relieve surface tension and membrane expansion drives protein association","volume":"125","author":"Kim","year":"2021","journal-title":"J Phys Chem B"},{"key":"2026090913511021400_pwag048-B154","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","article-title":"The perilipins: major cytosolic lipid droplet-associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis","volume":"36","author":"Kimmel","year":"2016","journal-title":"Annu Rev Nutr"},{"key":"2026090913511021400_pwag048-B155","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1038\/s41467-021-26162-6","article-title":"Mechanism of lipid droplet formation by the yeast Sei1\/Ldb16 seipin complex","volume":"12","author":"Klug","year":"2021","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B156","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41467-019-14176-0","article-title":"Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5","volume":"11","author":"Kong","year":"2020","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B157","doi-asserted-by":"crossref","first-page":"9413","DOI":"10.1038\/s41467-024-53667-7","article-title":"Molecular probes for tracking lipid droplet membrane dynamics","volume":"15","author":"Kong","year":"2024","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B158","doi-asserted-by":"crossref","first-page":"e2517469122","DOI":"10.1073\/pnas.2517469122","article-title":"ATG2 is a triglyceride transfer protein","volume":"122","author":"Korfhage","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B159","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tcb.2016.02.007","article-title":"Targeting fat: mechanisms of protein localization to lipid droplets","volume":"26","author":"Kory","year":"2016","journal-title":"Trends Cell Biol"},{"key":"2026090913511021400_pwag048-B160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.devcel.2015.06.007","article-title":"Protein crowding is a determinant of lipid droplet protein composition","volume":"34","author":"Kory","year":"2015","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B161","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cmet.2011.07.013","article-title":"Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP: phosphocholine cytidylyltransferase","volume":"14","author":"Krahmer","year":"2011","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B162","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1600-0854.2007.00689.x","article-title":"Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets","volume":"9","author":"Kuerschner","year":"2008","journal-title":"Traffic"},{"key":"2026090913511021400_pwag048-B163","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12964-025-02581-6","article-title":"C18ORF32 modulates lipid droplet secretion via secretory autophagy and restrains hepatic steatosis in vivo","volume":"24","author":"Kumar","year":"2025","journal-title":"Cell Commun Signal"},{"key":"2026090913511021400_pwag048-B164","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B165","doi-asserted-by":"crossref","first-page":"151362","DOI":"10.1016\/j.ejcb.2023.151362","article-title":"Concept of lipid droplet biogenesis","volume":"102","author":"Kumari","year":"2023","journal-title":"Eur J Cell Biol"},{"key":"2026090913511021400_pwag048-B166","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nmeth.3179","article-title":"Directed evolution of APEX2 for electron microscopy and proximity labeling","volume":"12","author":"Lam","year":"2015","journal-title":"Nat Methods"},{"key":"2026090913511021400_pwag048-B167","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1038\/s41556-025-01790-y","article-title":"FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis","volume":"27","author":"Lange","year":"2025","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B168","doi-asserted-by":"crossref","first-page":"e3763","DOI":"10.1371\/journal.pone.0003763","article-title":"BicaudalD actively regulates microtubule motor activity in lipid droplet transport","volume":"3","author":"Larsen","year":"2008","journal-title":"PLoS One"},{"key":"2026090913511021400_pwag048-B169","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbalip.2012.10.005","article-title":"Nuclear lipid droplets: a novel nuclear domain","volume":"1831","author":"Layerenza","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B170","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1515\/hsz-2025-0216","article-title":"Jack of all trades\u2014the lipid droplet organization (LDO) proteins are multifunctional organelle surface receptors","volume":"406","author":"Leite","year":"2025","journal-title":"Biol Chem"},{"key":"2026090913511021400_pwag048-B171","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.cub.2014.05.022","article-title":"Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development","volume":"24","author":"Li","year":"2014","journal-title":"Curr Biol"},{"key":"2026090913511021400_pwag048-B172","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.1704277114","article-title":"Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway","volume":"114","author":"Li","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B173","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cmet.2024.03.014","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B174","doi-asserted-by":"crossref","first-page":"22071","DOI":"10.1021\/acs.analchem.5c03758","article-title":"Simultaneous dual-channel tracking lipid droplets dynamic behaviors and revealing the protective role in nonalcoholic fatty liver in mice","volume":"97","author":"Li","year":"2025","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B175","doi-asserted-by":"crossref","first-page":"eadr9755","DOI":"10.1126\/science.adr9755","article-title":"Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex","volume":"390","author":"Li","year":"2025","journal-title":"Science"},{"key":"2026090913511021400_pwag048-B176","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.cub.2012.09.018","article-title":"Lipid droplets control the maternal histone supply of drosophila embryos","volume":"22","author":"Li","year":"2012","journal-title":"Curr Biol"},{"key":"2026090913511021400_pwag048-B177","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1194\/jlr.M026591","article-title":"Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation","volume":"53","author":"Li","year":"2012","journal-title":"J Lipid Res"},{"key":"2026090913511021400_pwag048-B178","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1016\/j.molcel.2025.08.009","article-title":"A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response","volume":"85","author":"Li","year":"2025","journal-title":"Mol Cell"},{"key":"2026090913511021400_pwag048-B179","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.celrep.2019.03.025","article-title":"The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation","volume":"27","author":"Li","year":"2019","journal-title":"Cell Rep"},{"key":"2026090913511021400_pwag048-B180","doi-asserted-by":"crossref","first-page":"19782","DOI":"10.1038\/srep19782","article-title":"Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B181","doi-asserted-by":"crossref","first-page":"11964","DOI":"10.1021\/acs.analchem.6c00280","article-title":"Quantitatively sensing lipid droplets polarity in cells and atherosclerotic model with a novel naphthalimide-based fluorescent probe","volume":"98","author":"Li","year":"2026","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B182","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tcb.2024.10.010","article-title":"Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins","volume":"35","author":"Liang","year":"2025","journal-title":"Trends Cell Biol"},{"key":"2026090913511021400_pwag048-B183","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1091\/mbc.E19-05-0284","article-title":"Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes","volume":"30","author":"Liao","year":"2019","journal-title":"Mol Biol Cell"},{"key":"2026090913511021400_pwag048-B184","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B185","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuron.2023.10.023","article-title":"Amelioration of tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist","volume":"112","author":"Litvinchuk","year":"2024","journal-title":"Neuron"},{"key":"2026090913511021400_pwag048-B186","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/acschembio.4c00835","article-title":"Tools to dissect lipid droplet regulation, players, and mechanisms","volume":"20","author":"Liu","year":"2025","journal-title":"ACS Chem Biol"},{"key":"2026090913511021400_pwag048-B187","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.bbamcr.2007.02.004","article-title":"Rab-regulated interaction of early endosomes with lipid droplets","volume":"1773","author":"Liu","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B188","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cmet.2017.08.024","article-title":"The glia-neuron lactate shuttle and elevated ROS promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE\/D","volume":"26","author":"Liu","year":"2017","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B189","doi-asserted-by":"crossref","first-page":"127388","DOI":"10.1016\/j.saa.2025.127388","article-title":"Novel dual-responsive near-infrared fluorescent bio-probe for visualizing lipid droplet accumulation in living cell and non-alcoholic fatty liver mouse models","volume":"349","author":"Liu","year":"2026","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"2026090913511021400_pwag048-B190","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbalip.2018.04.018","article-title":"Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals","volume":"1863","author":"Liu","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2026090913511021400_pwag048-B191","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1074\/jbc.M311945200","article-title":"Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic","volume":"279","author":"Liu","year":"2004","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B192","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"2026090913511021400_pwag048-B193","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B194","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12944-025-02747-8","article-title":"Lipid droplet dynamics in type 2 diabetes and its complications: pathophysiological insights and therapeutic options","volume":"24","author":"Long","year":"2025","journal-title":"Lipids Health Dis"},{"key":"2026090913511021400_pwag048-B195","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1111\/febs.15429","article-title":"The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes","volume":"287","author":"L\u00f6we","year":"2020","journal-title":"Febs J"},{"key":"2026090913511021400_pwag048-B196","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1021\/acs.analchem.4c06472","article-title":"Analyzing the cholesteryl ester fraction in lipid droplets with a polarity-ultrasensitive fluorescence lifetime probe","volume":"97","author":"Lu","year":"2025","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B197","doi-asserted-by":"crossref","first-page":"101029","DOI":"10.1016\/j.plipres.2020.101029","article-title":"Lipid droplets throughout the evolutionary tree","volume":"78","author":"Lundquist","year":"2020","journal-title":"Prog Lipid Res"},{"key":"2026090913511021400_pwag048-B198","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1038\/s41467-024-49449-w","article-title":"A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain","volume":"15","author":"Madsen","year":"2024","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B199","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026090913511021400_pwag048-B200","doi-asserted-by":"crossref","first-page":"27293","DOI":"10.1074\/jbc.M301430200","article-title":"A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system","volume":"278","author":"Marchesan","year":"2003","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B201","doi-asserted-by":"crossref","first-page":"11901","DOI":"10.1074\/jbc.M600171200","article-title":"The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion","volume":"281","author":"Marcinkiewicz","year":"2006","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B202","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat Neurosci"},{"key":"2026090913511021400_pwag048-B203","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-nutr-071813-105336","article-title":"Autophagy and lipid droplets in the liver","volume":"35","author":"Martinez-Lopez","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"2026090913511021400_pwag048-B204","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-025-10064-4","article-title":"CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly","volume":"652","author":"Mathiowetz","year":"2026","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B205","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41556-024-01364-4","article-title":"Lipid droplets and cellular lipid flux","volume":"26","author":"Mathiowetz","year":"2024","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B206","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1083\/jcb.97.4.1156","article-title":"Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells","volume":"97","author":"McGookey","year":"1983","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B207","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41586-023-06497-4","article-title":"Identification of an alternative triglyceride biosynthesis pathway","volume":"621","author":"McLelland","year":"2023","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B208","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s42255-024-01047-2","article-title":"Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance \u03b2-oxidation and tumor cell proliferation","volume":"6","author":"Meng","year":"2024","journal-title":"Nat Metab"},{"key":"2026090913511021400_pwag048-B209","doi-asserted-by":"crossref","first-page":"113203","DOI":"10.1016\/j.celrep.2023.113203","article-title":"ARL8B mediates lipid droplet contact and delivery to lysosomes for lipid remobilization","volume":"42","author":"Menon","year":"2023","journal-title":"Cell Rep"},{"key":"2026090913511021400_pwag048-B210","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.devcel.2023.05.006","article-title":"PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport","volume":"58","author":"Miner","year":"2023","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B211","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/s41556-026-01963-3","article-title":"Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets","volume":"28","author":"Mizrak","year":"2026","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B212","doi-asserted-by":"crossref","first-page":"21330","DOI":"10.1074\/jbc.M110.202424","article-title":"Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine","volume":"286","author":"Moessinger","year":"2011","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B213","doi-asserted-by":"crossref","first-page":"e1002890","DOI":"10.1371\/journal.pgen.1002890","article-title":"SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR","volume":"8","author":"Moir","year":"2012","journal-title":"PLoS Genet"},{"key":"2026090913511021400_pwag048-B214","doi-asserted-by":"crossref","first-page":"e1009602","DOI":"10.1371\/journal.pgen.1009602","article-title":"Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans","volume":"17","author":"Mosquera","year":"2021","journal-title":"PLoS Genet"},{"key":"2026090913511021400_pwag048-B215","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbalip.2008.07.004","article-title":"Lipid droplet-organelle interactions; sharing the fats","volume":"1791","author":"Murphy","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B216","doi-asserted-by":"crossref","first-page":"e15030","DOI":"10.1371\/journal.pone.0015030","article-title":"Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens","volume":"5","author":"Murphy","year":"2010","journal-title":"PLoS One"},{"key":"2026090913511021400_pwag048-B217","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0968-0004(98)01349-8","article-title":"Mechanisms of lipid-body formation","volume":"24","author":"Murphy","year":"1999","journal-title":"Trends Biochem Sci"},{"key":"2026090913511021400_pwag048-B218","doi-asserted-by":"crossref","first-page":"jeb163881","DOI":"10.1242\/jeb.163881","article-title":"Drosophila as a model to study obesity and metabolic disease","volume":"221","author":"Musselman","year":"2018","journal-title":"J Exp Biol"},{"key":"2026090913511021400_pwag048-B219","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bbamcr.2015.05.020","article-title":"Identification of lipid droplet structure-like\/resident proteins in Caenorhabditis elegans","volume":"1853","author":"Na","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-Dependent lipid droplet biogenesis protects mitochondrial function during Starvation-Induced autophagy","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B221","first-page":"2808","article-title":"FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets","volume":"118","author":"Nishino","year":"2008","journal-title":"J Clin Invest"},{"key":"2026090913511021400_pwag048-B222","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.chembiol.2013.08.009","article-title":"Open questions in lipid droplet biology","volume":"21","author":"Ohsaki","year":"2014","journal-title":"Chem Biol"},{"key":"2026090913511021400_pwag048-B223","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.devcel.2020.07.001","article-title":"Determinants of endoplasmic reticulum-to-lipid droplet protein targeting","volume":"54","author":"Olarte","year":"2020","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B224","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tibs.2021.08.007","article-title":"The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting","volume":"47","author":"Olarte","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"2026090913511021400_pwag048-B225","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090913511021400_pwag048-B226","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12944-017-0521-7","article-title":"Lipid droplets in health and disease","volume":"16","author":"Onal","year":"2017","journal-title":"Lipids Health Dis"},{"key":"2026090913511021400_pwag048-B227","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2023.01.007","article-title":"Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle","volume":"58","author":"Ouyang","year":"2023","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B228","doi-asserted-by":"crossref","first-page":"102541","DOI":"10.1016\/j.ceb.2025.102541","article-title":"New players on lipid droplets: their regulations and functions","volume":"95","author":"Pan","year":"2025","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B229","doi-asserted-by":"crossref","first-page":"106996","DOI":"10.1016\/j.prostaglandins.2025.106996","article-title":"Advances and challenges in lipid droplet isolation from animal tissues and cells","volume":"178","author":"Pei","year":"2025","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2026090913511021400_pwag048-B230","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41556-026-01880-5","article-title":"Cellular mechanisms of brain lipid metabolism in health and disease","volume":"28","author":"Petrelli","year":"2026","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B231","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.immuni.2025.04.029","article-title":"Amyloid-\u03b2 induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer\u2019s disease","volume":"58","author":"Prakash","year":"2025","journal-title":"Immunity"},{"key":"2026090913511021400_pwag048-B232","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2017.12.011","article-title":"Mechanism and determinants of amphipathic helix-containing protein targeting to lipid droplets","volume":"44","author":"Pr\u00e9vost","year":"2018","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B233","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s13238-011-1061-y","article-title":"Interactomic study on interaction between lipid droplets and mitochondria","volume":"2","author":"Pu","year":"2011","journal-title":"Protein Cell"},{"key":"2026090913511021400_pwag048-B234","doi-asserted-by":"crossref","first-page":"34213","DOI":"10.1074\/jbc.M707404200","article-title":"Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage","volume":"282","author":"Puri","year":"2007","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B235","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1073\/pnas.0802063105","article-title":"Cidea is associated with lipid droplets and insulin sensitivity in humans","volume":"105","author":"Puri","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B236","doi-asserted-by":"crossref","first-page":"108572","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep"},{"key":"2026090913511021400_pwag048-B237","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI85963","article-title":"HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage","volume":"127","author":"Qian","year":"2017","journal-title":"J Clin Invest"},{"key":"2026090913511021400_pwag048-B238","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1021\/acs.jafc.3c09764","article-title":"Combining metabolic engineering and lipid droplet assembly to achieve campesterol overproduction in Saccharomyces cerevisiae","volume":"72","author":"Qin","year":"2024","journal-title":"J Agric Food Chem"},{"key":"2026090913511021400_pwag048-B239","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj2350057","article-title":"Characteristics and biosynthesis of membrane proteins of lipid bodies in the scutella of maize (Zea mays L.)","volume":"235","author":"Qu","year":"1986","journal-title":"Biochem J"},{"key":"2026090913511021400_pwag048-B240","doi-asserted-by":"crossref","first-page":"101141","DOI":"10.1016\/j.plipres.2021.101141","article-title":"Hello from the other side: membrane contact of lipid droplets with other organelles and subsequent functional implications","volume":"85","author":"Rakotonirina-Ricquebourg","year":"2022","journal-title":"Prog Lipid Res"},{"key":"2026090913511021400_pwag048-B241","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102136","article-title":"Lipid droplets in the nervous system","volume":"220","author":"Ralhan","year":"2021","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B242","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1038\/s41467-021-27365-7","article-title":"Lipid droplet availability affects neural stem\/progenitor cell metabolism and proliferation","volume":"12","author":"Ramosaj","year":"2021","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B243","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bpj.2014.06.010","article-title":"Protein-induced membrane curvature alters local membrane tension","volume":"107","author":"Rangamani","year":"2014","journal-title":"Biophys J"},{"key":"2026090913511021400_pwag048-B244","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/icb.1971.19","article-title":"Association of Golgi membranes with lipid droplets (pre-chylomicrons) from within intestinal epithelial cells during absorption of fat","volume":"49","author":"Redgrave","year":"1971","journal-title":"Aust J Exp Biol Med Sci"},{"key":"2026090913511021400_pwag048-B245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-cellbio-031320-101827","article-title":"Protein quality control and lipid droplet metabolism","volume":"36","author":"Roberts","year":"2020","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2026090913511021400_pwag048-B246","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.cell.2018.05.047","article-title":"The inner nuclear membrane is a metabolically active territory that generates nuclear lipid droplets","volume":"174","author":"Romanauska","year":"2018","journal-title":"Cell"},{"key":"2026090913511021400_pwag048-B247","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.17.1.19","article-title":"Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation","volume":"17","author":"Sabatini","year":"1963","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B248","doi-asserted-by":"crossref","first-page":"1112954","DOI":"10.3389\/fcell.2023.1112954","article-title":"Seipin-still a mysterious protein?","volume":"11","author":"Salo","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"2026090913511021400_pwag048-B249","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/j.1460-2075.1985.tb03674.x","article-title":"Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages","volume":"4","author":"Schmitz","year":"1985","journal-title":"Embo J"},{"key":"2026090913511021400_pwag048-B250","doi-asserted-by":"crossref","first-page":"102070","DOI":"10.1016\/j.ceb.2022.02.004","article-title":"Seipin collaborates with the ER membrane to control the sites of lipid droplet formation","volume":"75","author":"Schneiter","year":"2022","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B251","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/jcbfm.2013.128","article-title":"Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain","volume":"33","author":"Sch\u00f6nfeld","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026090913511021400_pwag048-B252","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1083\/jcb.201803153","article-title":"Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes","volume":"218","author":"Schott","year":"2019","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B253","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/ncb3373","article-title":"Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains","volume":"18","author":"Schrul","year":"2016","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B254","doi-asserted-by":"crossref","first-page":"32443","DOI":"10.1073\/pnas.2011442117","article-title":"Direct lysosome-based autophagy of lipid droplets in hepatocytes","volume":"117","author":"Schulze","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B255","doi-asserted-by":"crossref","first-page":"e2420861122","DOI":"10.1073\/pnas.2420861122","article-title":"A hydrophobic photouncaging reaction to profile the lipid droplet interactome in tissues","volume":"122","author":"Shen","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B256","doi-asserted-by":"crossref","first-page":"e2318619121","DOI":"10.1073\/pnas.2318619121","article-title":"The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics","volume":"121","author":"Sherman","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B257","doi-asserted-by":"crossref","first-page":"23795","DOI":"10.1038\/srep23795","article-title":"Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes","volume":"6","author":"Shimabukuro","year":"2016","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B258","doi-asserted-by":"crossref","first-page":"e1001041","DOI":"10.1371\/journal.pbio.1001041","article-title":"A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms","volume":"9","author":"Shu","year":"2011","journal-title":"PLoS Biol"},{"key":"2026090913511021400_pwag048-B259","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz4564","article-title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","volume":"13","author":"Sienski","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026090913511021400_pwag048-B260","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrm3700","article-title":"Peroxisomes take shape","volume":"14","author":"Smith","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026090913511021400_pwag048-B261","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41467-019-08411-x","article-title":"Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis","volume":"10","author":"So\u0142tysik","year":"2019","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B262","doi-asserted-by":"crossref","first-page":"e202005026","DOI":"10.1083\/jcb.202005026","article-title":"Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner","volume":"220","author":"Soltysik","year":"2021","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B263","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41556-022-00974-0","article-title":"Identification of two pathways mediating protein targeting from ER to lipid droplets","volume":"24","author":"Song","year":"2022","journal-title":"Nat Cell Biol"},{"key":"2026090913511021400_pwag048-B264","doi-asserted-by":"crossref","first-page":"104288","DOI":"10.1016\/j.isci.2022.104288","article-title":"Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets","volume":"25","author":"Song","year":"2022","journal-title":"iScience"},{"key":"2026090913511021400_pwag048-B265","doi-asserted-by":"crossref","first-page":"40273","DOI":"10.1074\/jbc.M607986200","article-title":"Membrane topology and identification of key functional amino acid residues of murine acyl-CoA: diacylglycerol acyltransferase-2","volume":"281","author":"Stone","year":"2006","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B266","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1074\/jbc.M805768200","article-title":"The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria","volume":"284","author":"Stone","year":"2009","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B267","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1073\/pnas.1410741111","article-title":"Comparative proteomic study reveals 17\u03b2-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease","volume":"111","author":"Su","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B268","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2026090913511021400_pwag048-B269","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.200210169","article-title":"Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation","volume":"161","author":"Sztalryd","year":"2003","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B270","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B271","doi-asserted-by":"crossref","first-page":"44507","DOI":"10.1074\/jbc.M207712200","article-title":"The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition","volume":"277","author":"Tauchi-Sato","year":"2002","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B272","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.tcb.2017.07.006","article-title":"Emerging roles for the lysosome in lipid metabolism","volume":"27","author":"Thelen","year":"2017","journal-title":"Trends Cell Biol"},{"key":"2026090913511021400_pwag048-B273","doi-asserted-by":"crossref","first-page":"13244","DOI":"10.1073\/pnas.1307685110","article-title":"COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function","volume":"110","author":"Thiam","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B274","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1242\/jcs.192021","article-title":"The why, when and how of lipid droplet diversity","volume":"130","author":"Thiam","year":"2017","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B275","doi-asserted-by":"crossref","first-page":"e202602009","DOI":"10.1083\/jcb.202602009","article-title":"Seipin: a central lipid rheostat","volume":"225","author":"Thiam","year":"2026","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B276","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/j.bmcl.2016.05.034","article-title":"Photoactivatable protein labeling by singlet oxygen mediated reactions","volume":"26","author":"To","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"2026090913511021400_pwag048-B277","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.devcel.2019.07.021","article-title":"Drosophila snazarus regulates a lipid droplet population at plasma Membrane-Droplet contacts in adipocytes","volume":"50","author":"Ugrankar","year":"2019","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B278","doi-asserted-by":"crossref","first-page":"23699","DOI":"10.1074\/jbc.M310546200","article-title":"Association of stomatin with lipid bodies","volume":"279","author":"Umlauf","year":"2004","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B279","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/1756-0500-6-386","article-title":"Nuclear lipid droplets identified by electron microscopy of serial sections","volume":"6","author":"Uzbekov","year":"2013","journal-title":"BMC Res Notes"},{"key":"2026090913511021400_pwag048-B280","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1016\/j.molcel.2022.10.017","article-title":"ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation","volume":"82","author":"van Vliet","year":"2022","journal-title":"Mol Cell"},{"key":"2026090913511021400_pwag048-B281","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261081","article-title":"Exploring the ATG9A interactome uncovers interaction with VPS13A","volume":"137","author":"van Vliet","year":"2024","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B282","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41583-025-00908-3","article-title":"Lipid metabolism, remodelling and intercellular transfer in the CNS","volume":"26","author":"Vanherle","year":"2025","journal-title":"Nat Rev Neurosci"},{"key":"2026090913511021400_pwag048-B283","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.stem.2022.07.005","article-title":"Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity","volume":"29","author":"Victor","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2026090913511021400_pwag048-B284","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbalip.2008.10.009","article-title":"The life of lipid droplets","volume":"1791","author":"Walther","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tem.2013.10.003","article-title":"What are lipoproteins doing in the brain?","volume":"25","author":"Wang","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"2026090913511021400_pwag048-B286","doi-asserted-by":"crossref","first-page":"e2404713","DOI":"10.1002\/adhm.202404713","article-title":"A solvatochromic and photosensitized lipid droplet probe detects local polarity heterogeneity and labels interacting proteins in human liver disease tissue","volume":"14","author":"Wang","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"2026090913511021400_pwag048-B287","doi-asserted-by":"crossref","first-page":"41514","DOI":"10.1021\/jacs.5c11742","article-title":"Single-cell fluorescence analysis of lipid droplet compositional dynamics during triacylglycerol catabolism","volume":"147","author":"Wang","year":"2025","journal-title":"J Am Chem Soc"},{"key":"2026090913511021400_pwag048-B288","doi-asserted-by":"crossref","first-page":"102179","DOI":"10.1016\/j.jbc.2022.102179","article-title":"Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans","volume":"298","author":"Wang","year":"2022","journal-title":"J Biol Chem"},{"key":"2026090913511021400_pwag048-B289","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nm.2614","article-title":"Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids","volume":"18","author":"Wang","year":"2012","journal-title":"Nat Med"},{"key":"2026090913511021400_pwag048-B290","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13024-022-00577-1","article-title":"Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination","volume":"17","author":"Wang","year":"2022","journal-title":"Mol Neurodegener"},{"key":"2026090913511021400_pwag048-B291","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1038\/srep12070","article-title":"Proteomic analysis of murine testes lipid droplets","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B292","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbalip.2016.01.006","article-title":"Autophagy, lipophagy and lysosomal lipid storage disorders","volume":"1861","author":"Ward","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B293","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/14728222.2026.2671694","article-title":"Relevance of lipid droplets in metabolic dysfunction-associated steatotic liver disease","volume":"30","author":"Weiskirchen","year":"2026","journal-title":"Expert Opin Ther Targets"},{"key":"2026090913511021400_pwag048-B294","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1039\/D6CB00081A","article-title":"Lipid droplet dynamics in metabolic regulation","volume":"7","author":"Weiskirchen","year":"2026","journal-title":"RSC Chem Biol"},{"key":"2026090913511021400_pwag048-B295","doi-asserted-by":"crossref","first-page":"R470","DOI":"10.1016\/j.cub.2015.04.004","article-title":"Expanding roles for lipid droplets","volume":"25","author":"Welte","year":"2015","journal-title":"Curr Biol"},{"key":"2026090913511021400_pwag048-B296","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ceb.2014.03.008","article-title":"Lipid droplet biogenesis","volume":"29","author":"Wilfling","year":"2014","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B297","doi-asserted-by":"crossref","first-page":"e01607","DOI":"10.7554\/eLife.01607","article-title":"Arf1\/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting","volume":"3","author":"Wilfling","year":"2014","journal-title":"Elife"},{"key":"2026090913511021400_pwag048-B298","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B299","doi-asserted-by":"crossref","first-page":"e202305003","DOI":"10.1083\/jcb.202305003","article-title":"APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size","volume":"223","author":"Windham","year":"2024","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B300","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1016\/j.febslet.2006.08.040","article-title":"A proposed model of fat packaging by exchangeable lipid droplet proteins","volume":"580","author":"Wolins","year":"2006","journal-title":"FEBS Lett"},{"key":"2026090913511021400_pwag048-B301","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/1873-3468.14874","article-title":"The lipid droplet lipidome","volume":"598","author":"W\u00f6lk","year":"2024","journal-title":"FEBS Lett"},{"key":"2026090913511021400_pwag048-B302","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature25486","article-title":"Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis","volume":"554","author":"Wong","year":"2018","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B303","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.devcel.2025.03.005","article-title":"ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form","volume":"60","author":"Wright","year":"2025","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B304","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5835","article-title":"Here, there, and everywhere: the importance of ER membrane contact sites","volume":"361","author":"Wu","year":"2018","journal-title":"Science"},{"key":"2026090913511021400_pwag048-B305","doi-asserted-by":"crossref","first-page":"126842","DOI":"10.1016\/j.saa.2025.126842","article-title":"An electroneutral fluorescent probe for visualization of lipid droplets polarity heterogeneity and NAFLD detection","volume":"346","author":"Wu","year":"2026","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"2026090913511021400_pwag048-B306","doi-asserted-by":"crossref","first-page":"e2504219122","DOI":"10.1073\/pnas.2504219122","article-title":"PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis","volume":"122","author":"Wu","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B307","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1021\/acsnano.5c19175","article-title":"A nature-inspired steroid-like electron acceptor to polarity-dependent probe for visualizing lipid evolution in Alzheimer\u2019s disease","volume":"20","author":"Wu","year":"2026","journal-title":"ACS Nano"},{"key":"2026090913511021400_pwag048-B308","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41586-026-10161-y","article-title":"CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis","volume":"652","author":"Wu","year":"2026","journal-title":"Nature"},{"key":"2026090913511021400_pwag048-B309","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.devcel.2014.07.005","article-title":"Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth","volume":"30","author":"Wu","year":"2014","journal-title":"Dev Cell"},{"key":"2026090913511021400_pwag048-B310","doi-asserted-by":"crossref","first-page":"10724","DOI":"10.1021\/jacs.5c01710","article-title":"Chemical probe-enabled lipid droplet proteomics","volume":"147","author":"Xiang","year":"2025","journal-title":"J Am Chem Soc"},{"key":"2026090913511021400_pwag048-B311","doi-asserted-by":"crossref","first-page":"14902","DOI":"10.1038\/s41598-019-51399-z","article-title":"MDT-28\/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans","volume":"9","author":"Xie","year":"2019","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B312","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/ATVBAHA.111.241489","article-title":"CIDE proteins and lipid metabolism","volume":"32","author":"Xu","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026090913511021400_pwag048-B313","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1038\/s44318-024-00288-x","article-title":"Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes","volume":"43","author":"Xu","year":"2024","journal-title":"Embo J"},{"key":"2026090913511021400_pwag048-B314","author":"Xu","year":"2025"},{"key":"2026090913511021400_pwag048-B315","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.201201139","article-title":"The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface","volume":"198","author":"Xu","year":"2012","journal-title":"J Cell Biol"},{"key":"2026090913511021400_pwag048-B316","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.bbadis.2017.07.019","article-title":"Lipid droplet proteins and metabolic diseases","volume":"1864","author":"Xu","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026090913511021400_pwag048-B317","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1194\/jlr.R024117","article-title":"The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans","volume":"53","author":"Yang","year":"2012","journal-title":"J Lipid Res"},{"key":"2026090913511021400_pwag048-B318","doi-asserted-by":"crossref","first-page":"e2508912122","DOI":"10.1073\/pnas.2508912122","article-title":"CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis","volume":"122","author":"Yang","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B319","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ceb.2012.05.012","article-title":"Controlling the size of lipid droplets: lipid and protein factors","volume":"24","author":"Yang","year":"2012","journal-title":"Curr Opin Cell Biol"},{"key":"2026090913511021400_pwag048-B320","doi-asserted-by":"crossref","first-page":"e50214","DOI":"10.15252\/embr.202050214","article-title":"Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration","volume":"21","author":"Yang","year":"2020","journal-title":"EMBO Rep"},{"key":"2026090913511021400_pwag048-B321","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2008.12.013","article-title":"Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B","volume":"9","author":"Ye","year":"2009","journal-title":"Cell Metab"},{"key":"2026090913511021400_pwag048-B322","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1111\/j.1742-4658.2007.06005.x","article-title":"Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver","volume":"274","author":"Yokoi","year":"2007","journal-title":"Febs J"},{"key":"2026090913511021400_pwag048-B323","doi-asserted-by":"crossref","first-page":"e1800136","DOI":"10.1002\/pmic.201800136","article-title":"The adrenal lipid droplet is a new site for steroid hormone metabolism","volume":"18","author":"Yu","year":"2018","journal-title":"Proteomics"},{"key":"2026090913511021400_pwag048-B324","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.bbamcr.2015.01.020","article-title":"Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment","volume":"1853","author":"Yu","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2026090913511021400_pwag048-B325","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"2026090913511021400_pwag048-B326","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1242\/jcs.012013","article-title":"Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets","volume":"121","author":"Zehmer","year":"2008","journal-title":"J Cell Sci"},{"key":"2026090913511021400_pwag048-B327","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/pmic.200800584","article-title":"A role for lipid droplets in inter-membrane lipid traffic","volume":"9","author":"Zehmer","year":"2009","journal-title":"Proteomics"},{"key":"2026090913511021400_pwag048-B328","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1038\/s41467-022-32689-z","article-title":"Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling","volume":"13","author":"Zhai","year":"2022","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B329","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.molcel.2022.01.021","article-title":"Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination","volume":"82","author":"Zhang","year":"2022","journal-title":"Mol Cell"},{"key":"2026090913511021400_pwag048-B330","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s13238-017-0467-6","article-title":"The lipid droplet: a conserved cellular organelle","volume":"8","author":"Zhang","year":"2017","journal-title":"Protein Cell"},{"key":"2026090913511021400_pwag048-B331","doi-asserted-by":"crossref","first-page":"e1700223","DOI":"10.1002\/pmic.201700223","article-title":"The new face of the lipid droplet: lipid droplet proteins","volume":"19","author":"Zhang","year":"2019","journal-title":"Proteomics"},{"key":"2026090913511021400_pwag048-B332","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1074\/mcp.M111.016345","article-title":"Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets","volume":"11","author":"Zhang","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"2026090913511021400_pwag048-B333","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1128\/MCB.01723-13","article-title":"Cidea control of lipid storage and secretion in mouse and human sebaceous glands","volume":"34","author":"Zhang","year":"2014","journal-title":"Mol Cell Biol"},{"key":"2026090913511021400_pwag048-B334","doi-asserted-by":"crossref","first-page":"29539","DOI":"10.1038\/srep29539","article-title":"Morphologically and functionally distinct lipid droplet subpopulations","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"2026090913511021400_pwag048-B335","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/pr200553c","article-title":"Proteome of skeletal muscle lipid droplet reveals association with mitochondria and apolipoprotein a-I","volume":"10","author":"Zhang","year":"2011","journal-title":"J Proteome Res"},{"key":"2026090913511021400_pwag048-B336","doi-asserted-by":"crossref","first-page":"9475","DOI":"10.1038\/s41467-024-53750-z","article-title":"CLSTN3B promotes lipid droplet maturation and lipid storage in mouse adipocytes","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"2026090913511021400_pwag048-B337","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-025-03334-5","article-title":"Lipid droplets in Central nervous system and functional profiles of brain cells containing lipid droplets in various diseases","volume":"22","author":"Zhang","year":"2025","journal-title":"J Neuroinflammation"},{"key":"2026090913511021400_pwag048-B338","doi-asserted-by":"crossref","first-page":"116475","DOI":"10.1016\/j.celrep.2025.116475","article-title":"The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility","volume":"44","author":"Zhao","year":"2025","journal-title":"Cell Rep"},{"key":"2026090913511021400_pwag048-B339","doi-asserted-by":"crossref","first-page":"e2113074119","DOI":"10.1073\/pnas.2113074119","article-title":"Destabilization of \u03b2 cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes","volume":"119","author":"Zheng","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090913511021400_pwag048-B340","doi-asserted-by":"crossref","first-page":"16557","DOI":"10.1021\/acs.analchem.5c02829","article-title":"Unveiling lipid droplet dynamics in Parkinson\u2019s disease via a polarity-responsive alkenyl Indole-Based fluorophore","volume":"97","author":"Zhu","year":"2025","journal-title":"Anal Chem"},{"key":"2026090913511021400_pwag048-B341","doi-asserted-by":"crossref","first-page":"e62886","DOI":"10.7554\/eLife.62886","article-title":"Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets","volume":"10","author":"Zoni","year":"2021","journal-title":"Elife"},{"key":"2026090913511021400_pwag048-B342","doi-asserted-by":"crossref","first-page":"14256","DOI":"10.1021\/acs.analchem.5c00894","article-title":"Lipid droplet-targeted BODIPY-hemicyanine hybrid fluorescent probes for real-time monitoring of pH and viscosity","volume":"97","author":"Zuo","year":"2025","journal-title":"Anal Chem"}],"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag048\/69063137\/pwag048.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag048\/69063137\/pwag048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:51:50Z","timestamp":1788976310000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article\/doi\/10.1093\/procel\/pwag048\/8736000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":342,"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag048","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"article-number":"pwag048"}}