{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:07:26Z","timestamp":1790273246821,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/procel\/pwag054","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:51:30Z","timestamp":1785498690000},"source":"Crossref","is-referenced-by-count":0,"title":["Super-resolution live imaging reveals spatiotemporal uncoupling of mitochondria-ER contacts and mitochondrial fission in stem cell aging"],"prefix":"10.1093","author":[{"given":"Tianling","family":"Cao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, IDG\/McGovern Institute for Brain Research, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University , Beijing 100084,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobin","family":"Jing","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, International Center for Aging and Cancer, Hainan Medical University , Haikou 571199,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"Aging Biomarker Consortium (ABC) , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-0612","authenticated-orcid":false,"given":"Si","family":"Wang","sequence":"additional","affiliation":[{"name":"Aging Biomarker Consortium (ABC) , Beijing 100101,","place":["China"]},{"name":"Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University , Beijing 100053,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-8177","authenticated-orcid":false,"given":"Guang-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"Aging Biomarker Consortium (ABC) , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-5125","authenticated-orcid":false,"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, IDG\/McGovern Institute for Brain Research, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University , Beijing 100084,","place":["China"]},{"name":"National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-5067","authenticated-orcid":false,"given":"Jing","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,","place":["China"]},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049,","place":["China"]},{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029,","place":["China"]},{"name":"Aging Biomarker Consortium (ABC) , Beijing 100101,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"2026092413263524400_pwag054-B1","doi-asserted-by":"crossref","first-page":"e201911122","DOI":"10.1083\/jcb.201911122","article-title":"Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology","volume":"219","author":"Abrisch","year":"2020","journal-title":"J Cell Biol"},{"key":"2026092413263524400_pwag054-B2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1083\/jcb.201709111","article-title":"INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division","volume":"217","author":"Chakrabarti","year":"2018","journal-title":"J Cell Biol"},{"key":"2026092413263524400_pwag054-B4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200604016","article-title":"Structural and functional features and significance of the physical linkage between ER and mitochondria","volume":"174","author":"Csord\u00e1s","year":"2006","journal-title":"J Cell Biol"},{"key":"2026092413263524400_pwag054-B5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","article-title":"Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions","volume":"28","author":"Csord\u00e1s","year":"2018","journal-title":"Trends Cell Biol"},{"key":"2026092413263524400_pwag054-B6","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.cell.2018.09.057","article-title":"Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond timescales","volume":"175","author":"Guo","year":"2018","journal-title":"Cell"},{"key":"2026092413263524400_pwag054-B9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1228360","article-title":"An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2","volume":"339","author":"Korobova","year":"2013","journal-title":"Science"},{"key":"2026092413263524400_pwag054-B10","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1038\/s44321-025-00279-3","article-title":"Convergent activation of the integrated stress response and ER-mitochondria uncoupling in VAPB-associated ALS","volume":"17","author":"Landry","year":"2025","journal-title":"EMBO Mol Med"},{"key":"2026092413263524400_pwag054-B11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41419-022-04942-2","article-title":"Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"2026092413263524400_pwag054-B12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"2026092413263524400_pwag054-B13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40478-024-01742-x","article-title":"Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD\/ALS mutant TDP43 linked Ca2+ and synaptic defects","volume":"12","author":"Markovinovic","year":"2024","journal-title":"Acta Neuropathol Commun"},{"key":"2026092413263524400_pwag054-B14","first-page":"25152564251329250","article-title":"Mitochondria-Lysosome contact sites: emerging players in cellular homeostasis and disease","volume":"8","author":"Rizzollo","year":"2025","journal-title":"Contact (Thousand Oaks)"},{"key":"2026092413263524400_pwag054-B15","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41467-025-56666-4","article-title":"ER-mitochondria contacts mediate lipid radical transfer via RMDN3\/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress","volume":"16","author":"Shiiba","year":"2025","journal-title":"Nat Commun"},{"issue":"10","key":"2026092413263524400_pwag054-B16","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202205135","article-title":"ER as master regulator of membrane trafficking and organelle function","volume":"221","author":"Wenzel","year":"2022","journal-title":"J Cell Biol"},{"key":"2026092413263524400_pwag054-B17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s13238-018-0517-8","article-title":"Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome","volume":"9","author":"Wu","year":"2018","journal-title":"Protein Cell"},{"key":"2026092413263524400_pwag054-B18","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s42003-021-02840-5","article-title":"Cellular senescence links mitochondria-ER contacts and aging","volume":"4","author":"Ziegler","year":"2021","journal-title":"Commun Biol"}],"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag054\/70413026\/pwag054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag054\/70413026\/pwag054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:44Z","timestamp":1790270804000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article\/doi\/10.1093\/procel\/pwag054\/8748508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag054","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"pwag054"}}