{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:08:22Z","timestamp":1792786102992,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2023YFA1801200"],"award-info":[{"award-number":["2023YFA1801200"]}]},{"name":"National Key Research and Development Project of China","award":["2024YFC3016401"],"award-info":[{"award-number":["2024YFC3016401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371178"],"award-info":[{"award-number":["32371178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471184"],"award-info":[{"award-number":["32471184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the\u00a0Ministry of Education of China","award":["JYB2025XDXM605"],"award-info":[{"award-number":["JYB2025XDXM605"]}],"id":[{"id":"https:\/\/ror.org\/03m01yf64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shaanxi Health Research Innovation Team Project","award":["2026TD-06"],"award-info":[{"award-number":["2026TD-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tryptophan catabolism by the gut microbiota is increasingly recognized as a hub connecting environmental challenges to cardiovascular health. By systematically profiling tryptophan metabolites in humans who had moved from low altitude to an altitude of 4,300\u2009m and in mice exposed to hypobaric hypoxia, we found that circulating and fecal levels of indole-3-propionic acid (IPA), a gut microbiota-derived tryptophan metabolite, are reduced in both settings, and these reductions correlate with the severity of cardiac injury. IPA supplementation in mice ameliorated hypobaric hypoxia-induced cardiac dysfunction. Mechanistically, IPA directly bound to hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) at residue P564, competitively inhibiting its interaction with von Hippel-Lindau protein and preventing proteasomal degradation, thereby stabilizing HIF-1\u03b1. HIF-1\u03b1 activation shifted cardiac metabolic substrate utilization from fatty acids to glucose and reduced oxygen consumption. Cardiomyocyte-specific HIF-1\u03b1 knockout completely abolished IPA\u2019s cardioprotective effects. Moreover, gut microbiota depletion abrogated the protective effect of tryptophan against hypobaric hypoxia exposure. Finally, IPA protected against myocardial infarction in a HIF-1\u03b1-dependent manner. These results suggest that IPA is an endogenous HIF-1\u03b1 agonist to protect the heart against hypoxia\/ischemia, representing a promising therapeutic candidate for hypoxic\/ischemic diseases.<\/jats:p>","DOI":"10.1093\/procel\/pwag067","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:33:30Z","timestamp":1788521610000},"source":"Crossref","is-referenced-by-count":0,"title":["Indole-3-propionic acid is an endogenic agonist of hypoxia-inducible factor-1\u03b1 to protect the heart against hypoxia"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-9340","authenticated-orcid":false,"given":"Ziang","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9398-582X","authenticated-orcid":false,"given":"Sen","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force, People\u2019s Liberation Army , Lanzhou 730050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-391X","authenticated-orcid":false,"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9917-3853","authenticated-orcid":false,"given":"Shichao","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6706-5659","authenticated-orcid":false,"given":"Lulu","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Northwestern Polytechnical University , Xi\u2019an 710129,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-1876","authenticated-orcid":false,"given":"Xiangyang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Pharmacy, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]},{"name":"Military Medical Innovation Center, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-6565","authenticated-orcid":false,"given":"Zhihui","family":"Feng","sequence":"additional","affiliation":[{"name":"Frontier Institute of Science and Technology, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]},{"name":"Military Medical Innovation Center, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-6551","authenticated-orcid":false,"given":"Xinghua","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Northwestern Polytechnical University , Xi\u2019an 710129,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7795-2489","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-1717","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-5038","authenticated-orcid":false,"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]},{"name":"Military Medical Innovation Center, Fourth Military Medical University , Xi\u2019an 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2026101312413490600_pwag067-B1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s43657-024-00180-y","article-title":"Differences in pathogenetic mechanism between Tibetan and Han high-altitude polycythemia based on a whole genome-wide association study","volume":"5","author":"Basang","year":"2025","journal-title":"Phenomics"},{"key":"2026101312413490600_pwag067-B2","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.cmet.2024.06.003","article-title":"Human cardiac metabolism","volume":"36","author":"Bornstein","year":"2024","journal-title":"Cell Metab"},{"key":"2026101312413490600_pwag067-B3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-025-02531-1","article-title":"Altitude hypoxia and hypoxemia: pathogenesis and management","volume":"11","author":"Cai","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"2026101312413490600_pwag067-B4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cmet.2017.10.005","article-title":"Advances in hypoxia-inducible factor biology","volume":"27","author":"Choudhry","year":"2018","journal-title":"Cell Metab"},{"key":"2026101312413490600_pwag067-B5","doi-asserted-by":"crossref","first-page":"e023225","DOI":"10.1161\/JAHA.121.023225","article-title":"Clinical implications for exercise at altitude among individuals with cardiovascular disease: a scientific statement from the American Heart Association","volume":"10","author":"Cornwell","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026101312413490600_pwag067-B6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41392-025-02500-8","article-title":"The aryl hydrocarbon receptor: structure, signaling, physiology and pathology","volume":"11","author":"Coumoul","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"2026101312413490600_pwag067-B7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCULATIONAHA.107.758516","article-title":"Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning","volume":"118","author":"Eckle","year":"2008","journal-title":"Circulation"},{"key":"2026101312413490600_pwag067-B8","doi-asserted-by":"crossref","first-page":"121923","DOI":"10.1016\/j.lfs.2023.121923","article-title":"Exercise in cold: friend than foe to cardiovascular health","volume":"328","author":"Feng","year":"2023","journal-title":"Life Sci"},{"key":"2026101312413490600_pwag067-B9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2026.01.064","article-title":"MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy","volume":"247","author":"Feng","year":"2026","journal-title":"Free Radic Biol Med"},{"key":"2026101312413490600_pwag067-B10","doi-asserted-by":"crossref","first-page":"102848","DOI":"10.1016\/j.arr.2025.102848","article-title":"Exercise as elixir to combat cardiovascular ageing","volume":"111","author":"Feng","year":"2025","journal-title":"Ageing Res Rev"},{"key":"2026101312413490600_pwag067-B11","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13050988","article-title":"HIF-prolyl hydroxylase domain proteins (PHDs) in cancer-potential targets for anti-tumor therapy?","volume":"13","author":"Gaete","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2026101312413490600_pwag067-B12","doi-asserted-by":"crossref","first-page":"2467235","DOI":"10.1080\/19490976.2025.2467235","article-title":"Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1\/Th17 cell apoptosis in inflammatory bowel disease","volume":"17","author":"Gao","year":"2025","journal-title":"Gut Microbes"},{"key":"2026101312413490600_pwag067-B13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-024-00526-w","article-title":"Altitude illnesses","volume":"10","author":"Gatterer","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"2026101312413490600_pwag067-B14","doi-asserted-by":"crossref","first-page":"690600","DOI":"10.3389\/fmicb.2021.690600","article-title":"Hypoxia: the \u201cinvisible pusher\u201d of gut microbiota","volume":"12","author":"Han","year":"2021","journal-title":"Front Microbiol"},{"key":"2026101312413490600_pwag067-B15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.molmed.2022.09.004","article-title":"Molecular basis and clinical implications of HIFs in cardiovascular diseases","volume":"28","author":"Hu","year":"2022","journal-title":"Trends Mol Med"},{"key":"2026101312413490600_pwag067-B16","doi-asserted-by":"crossref","first-page":"121284","DOI":"10.1016\/j.lfs.2022.121284","article-title":"Temperature-dependent metabolite orchestration to acute submaximal exercise indicates cardiorespiratory fitness in humans","volume":"313","author":"Hu","year":"2023","journal-title":"Life Sci"},{"key":"2026101312413490600_pwag067-B17","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41467-025-58107-8","article-title":"Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against alphaPD1-induced cardiotoxicity in mice","volume":"16","author":"Huang","year":"2025","journal-title":"Nat Commun"},{"key":"2026101312413490600_pwag067-B18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"2026101312413490600_pwag067-B19","first-page":"1","article-title":"Hypoxia signaling in human diseases and therapeutic targets","volume":"51","author":"Lee","year":"2019","journal-title":"Exp Mol Med"},{"key":"2026101312413490600_pwag067-B20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s43657-025-00264-3","article-title":"Body composition-derived subtypes in tibetan adults residing at Qinghai-high plateau and their associations with distinct metabolite profiles and cardiometabolic outcomes","volume":"5","author":"Li","year":"2025","journal-title":"Phenomics"},{"key":"2026101312413490600_pwag067-B21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41420-026-02960-z","article-title":"Novel mechanism of neuronal hypoxia response: HIF-1alpha\/STOML2 mediated PINK1-dependent mitophagy activation against neuronal injury","volume":"12","author":"Li","year":"2026","journal-title":"Cell Death Discov"},{"key":"2026101312413490600_pwag067-B22","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.120.051937","article-title":"Suppression of myocardial Hypoxia-Inducible factor-1alpha compromises metabolic adaptation and impairs cardiac function in patients with cyanotic congenital heart disease during puberty","volume":"143","author":"Liu","year":"2021","journal-title":"Circulation"},{"key":"2026101312413490600_pwag067-B23","doi-asserted-by":"crossref","first-page":"103580","DOI":"10.1016\/j.redox.2025.103580","article-title":"Decreased gut microbiome-derived indole-3-propionic acid mediates the exacerbation of myocardial ischemia\/reperfusion injury following depression via the brain-gut-heart axis","volume":"81","author":"Mu","year":"2025","journal-title":"Redox Biol"},{"key":"2026101312413490600_pwag067-B24","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/eurheartj\/ehad333","article-title":"Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality","volume":"44","author":"Nemet","year":"2023","journal-title":"Eur Heart J"},{"key":"2026101312413490600_pwag067-B25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/CIRCULATIONAHA.106.624544","article-title":"The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness","volume":"115","author":"Penaloza","year":"2007","journal-title":"Circulation"},{"key":"2026101312413490600_pwag067-B26","doi-asserted-by":"crossref","first-page":"117753","DOI":"10.1016\/j.bcp.2026.117753","article-title":"Hypoxia-inducible factor-1alpha in cardiovascular disease, mechanistic insights, pathophysiological roles, and therapeutic targeting strategies","volume":"246","author":"Rahman","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"2026101312413490600_pwag067-B27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41569-023-00924-9","article-title":"Cardiovascular physiology and pathophysiology at high altitude","volume":"21","author":"Richalet","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026101312413490600_pwag067-B28","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat Commun"},{"key":"2026101312413490600_pwag067-B29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.25259\/ijn_389_23","article-title":"Hypoxia-inducible factor prolyl hydroxylase inhibitors for treatment of anemia in chronic kidney disease: guidelines for South Asia","volume":"35","author":"South Asia HIF-PHI for Anemia in CKD Guideline Development Group","year":"2025","journal-title":"Indian J Nephrol"},{"key":"2026101312413490600_pwag067-B30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/CIRCRESAHA.123.322381","article-title":"Indole-3-Propionic acid protects against heart failure with preserved ejection fraction","volume":"134","author":"Wang","year":"2024","journal-title":"Circ Res"},{"key":"2026101312413490600_pwag067-B31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s13105-023-00966-0","article-title":"HIF-1 signaling: an emerging mechanism for mitochondrial dynamics","volume":"79","author":"Xin","year":"2023","journal-title":"J Physiol Biochem"},{"key":"2026101312413490600_pwag067-B32","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan metabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell Metab"},{"key":"2026101312413490600_pwag067-B33","doi-asserted-by":"crossref","first-page":"9630","DOI":"10.1073\/pnas.181341498","article-title":"HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation","volume":"98","author":"Yu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101312413490600_pwag067-B34","doi-asserted-by":"crossref","first-page":"e326990","DOI":"10.1161\/CIRCRESAHA.125.326990","article-title":"Indole-3 acetate limits dysbiosis-driven diastolic failure via hcrt neurons","volume":"138","author":"Zakarauskas-Seth","year":"2026","journal-title":"Circ Res"},{"key":"2026101312413490600_pwag067-B35","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.2147\/JIR.S466777","article-title":"Pretreatment with indole-3-propionic acid attenuates lipopolysaccharide-Induced cardiac dysfunction and inflammation through the AhR\/NF-kappaB\/NLRP3 pathway","volume":"17","author":"Zhang","year":"2024","journal-title":"J Inflamm Res"},{"key":"2026101312413490600_pwag067-B36","article-title":"A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a hopx-associated program","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat Commun"},{"key":"2026101312413490600_pwag067-B37","doi-asserted-by":"crossref","first-page":"103675","DOI":"10.1016\/j.redox.2025.103675","article-title":"Hypobaric hypoxia-driven energy metabolism disturbance facilitates vascular endothelial dysfunction","volume":"84","author":"Zhang","year":"2025","journal-title":"Redox Biol"},{"key":"2026101312413490600_pwag067-B38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00395-009-0044-0","article-title":"Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha","volume":"105","author":"Zhao","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"2026101312413490600_pwag067-B39","doi-asserted-by":"crossref","first-page":"107896","DOI":"10.1016\/j.phrs.2025.107896","article-title":"Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment","volume":"219","author":"Zhao","year":"2025","journal-title":"Pharmacol Res"},{"key":"2026101312413490600_pwag067-B40","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41392-023-01652-9","article-title":"Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026101312413490600_pwag067-B41","doi-asserted-by":"crossref","first-page":"20240332","DOI":"10.1002\/EXP.20240332","article-title":"Gut microbiota-associated metabolites affected the susceptibility to heart health abnormality in young migrants at high-altitude: gut microbiota and associated metabolites impart heart health in plateau","volume":"5","author":"Zhou","year":"2025","journal-title":"Exploration (Beijing)"}],"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag067\/70964103\/pwag067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag067\/70964103\/pwag067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:41:47Z","timestamp":1791909707000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article\/doi\/10.1093\/procel\/pwag067\/8785889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":41,"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag067","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"article-number":"pwag067"}}