{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:35Z","timestamp":1790172575635,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cold stress severely challenges the cardiovascular system under distinct physiological contexts: environmental cold exposure, systemic hypothermia, and donor heart cold preservation. Yet, hibernating mammals remarkably tolerate these extremes without evident injury, offering ideal models to decipher cardiac cold adaptation. Here, we induced hibernation in Syrian hamsters, a mammalian hibernator, under controlled cold stress (4\u2009\u00b0C ambient, \u223c5\u2009\u00b0C body temperature). Notably, torpid Syrian hamsters exhibited reversible cardiac hypertrophy, a process verified to represent physiological rather than pathological remodeling that enhances cardiac cold resilience. We further identified NDRG2 as a key effector, and its overexpression in non-hibernating mice recapitulated this adaptive phenotype, promoting physiological cardiac hypertrophy, attenuating pathological remodeling, and improving cardiac cold tolerance. Mechanistically, NDRG2 orchestrates a fatty acid metabolic program to mitigate cold-induced cardiac injury during hibernation. Collectively, our work identifies the NDRG2-fatty acid axis as a central mechanism integrating structural, metabolic, and functional adaptation to cold stress, providing unique insights into cardioprotection.<\/jats:p>","DOI":"10.1093\/procel\/pwag072","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:35:11Z","timestamp":1790076911000},"source":"Crossref","is-referenced-by-count":0,"title":["NDRG2 orchestrates structural and functional adaptation for cardioprotection during mammalian hibernation"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2189-9949","authenticated-orcid":false,"given":"Ning","family":"Guo","sequence":"first","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]},{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-9342","authenticated-orcid":false,"given":"Haijian","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]},{"name":"University of Macau Faculty of Health Sciences and UM-Bioland Joint Laboratory, , Macau 999078,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7318-1954","authenticated-orcid":false,"given":"Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University Zhongshan School of Medicine, , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-4107","authenticated-orcid":false,"given":"Chuman","family":"Wu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3877-7308","authenticated-orcid":false,"given":"Yifu","family":"Chen","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]},{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-4154","authenticated-orcid":false,"given":"Meifeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2916-8708","authenticated-orcid":false,"given":"Jiayu","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-2444","authenticated-orcid":false,"given":"Weiya","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou National Laboratory , Guangzhou 510005,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-9319","authenticated-orcid":false,"given":"Guanzheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1660-4728","authenticated-orcid":false,"given":"Nan","family":"Cao","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University Zhongshan School of Medicine, , Guangzhou 510080,","place":["China"]},{"name":"Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University) , Ministry of Education, Guangzhou 510080,","place":["China"]},{"name":"NHC Key Laboratory of Assisted Circulation (Sun Yat-Sen University) , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-2182","authenticated-orcid":false,"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University Innovation Center for Evolutionary Synthetic Biology, School of Life Sciences, , Guangzhou 510275,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-5284","authenticated-orcid":false,"given":"Ji","family":"Dong","sequence":"additional","affiliation":[{"name":"Fudan University State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, , Shanghai 200438,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,23]]},"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag072\/71348467\/pwag072.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag072\/71348467\/pwag072.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:55:30Z","timestamp":1790171730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article\/doi\/10.1093\/procel\/pwag072\/8832246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag072","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"pwag072"}}