{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:04:35Z","timestamp":1790863475225,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mosaic loss of the Y chromosome (mLOY) is a male\u2011specific somatic loss of the Y chromosome that is predominantly observed in peripheral blood leukocytes, but can also be found in other tissue types. It represents one of the most common male-specific somatic mutations, particularly prevalent in aging individuals. Accumulating evidence shows that mLOY markedly increases the incidence, progression, and adverse prognosis of multiple diseases, including, but not limited to, myocardial fibrosis, lung and bladder cancers, and Alzheimer\u2019s disease. Mechanistically, for extrinsic effects of mLOY, hematopoietic mLOY affect other cell populations, thereby promoting disease initiation and progression. From an intrinsic effects, mLOY within cells reprograms autosomal gene expression and reshapes interactions with the immune microenvironment, jointly driving malignant evolution. In this review, we summarize the current understanding of both intrinsic and extrinsic mLOY effects on immune regulation and disease pathogenesis, highlighting its multifaceted roles across cancer, cardiovascular disorders, infections, and other mLOY-associated conditions.<\/jats:p>","DOI":"10.1093\/procel\/pwag073","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:57:04Z","timestamp":1790769424000},"source":"Crossref","is-referenced-by-count":0,"title":["Mosaic Loss of the Y Chromosome: Mechanisms and Diseases"],"prefix":"10.1093","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Sichuan University Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Institute of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-5185","authenticated-orcid":false,"given":"Jiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Sichuan University Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Institute of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Department of Hematology, Institute of Hematology, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University National Facility for Translational Medicine (Sichuan), West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1241-1595","authenticated-orcid":false,"given":"Xiaoqian","family":"Zhai","sequence":"additional","affiliation":[{"name":"Sichuan University Department of Medical Oncology, Cancer Center, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Lung Cancer Center\/Lung Cancer Institute, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7331-2897","authenticated-orcid":false,"given":"Luocheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University Department of Hematology, Institute of Hematology, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University National Facility for Translational Medicine (Sichuan), West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1472-1209","authenticated-orcid":false,"given":"Junhui","family":"Peng","sequence":"additional","affiliation":[{"name":"National Center for Nanoscience and Technology of China , Beijing 100190,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Sichuan University Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Institute of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-9456","authenticated-orcid":false,"given":"Qinghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sichuan University Lung Cancer Center\/Lung Cancer Institute, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Department of Thoracic Surgery, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-1014","authenticated-orcid":false,"given":"Ting","family":"Niu","sequence":"additional","affiliation":[{"name":"Sichuan University Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Institute of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Department of Hematology, Institute of Hematology, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University National Facility for Translational Medicine (Sichuan), West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[{"name":"Sichuan University Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, West China Hospital, , Chengdu 610041,","place":["China"]},{"name":"Sichuan University Institute of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan University State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"container-title":["Protein &amp; Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag073\/71560039\/pwag073.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article-pdf\/doi\/10.1093\/procel\/pwag073\/71560039\/pwag073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:38:55Z","timestamp":1790861935000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/advance-article\/doi\/10.1093\/procel\/pwag073\/8859122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/procel\/pwag073","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"pwag073"}}