{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:39:55Z","timestamp":1789004395528,"version":"build-2803163510"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Engineering Design and Selection"],"published-print":{"date-parts":[[2011,5,1]]},"DOI":"10.1093\/protein\/gzr004","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T03:36:48Z","timestamp":1296185808000},"page":"429-437","source":"Crossref","is-referenced-by-count":27,"title":["Modulating the pH-activity profile of cellulase A from Cellulomonas fimi by replacement of surface residues"],"prefix":"10.1093","volume":"24","author":[{"given":"D. W.","family":"Cockburn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,27]]},"reference":[{"issue":"2","key":"1_17570935","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/proeng\/gzg017","volume":"16","author":"Andre","year":"2003","journal-title":"Protein Engineering Design and Selection","ISSN":"https:\/\/id.crossref.org\/issn\/1741-0126","issn-type":"print"},{"issue":"3","key":"2_32448141","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1002\/prot.22102","volume":"73","author":"Bas","year":"2008","journal-title":"Proteins","ISSN":"https:\/\/id.crossref.org\/issn\/0887-3585","issn-type":"print"},{"issue":"30","key":"3_22382744","doi-asserted-by":"publisher","first-page":"11417","DOI":"10.1073\/pnas.0604632103","volume":"103","year":"2006","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"4_39044169","first-page":"9","volume":"356","year":"2001","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"8","key":"6_15605190","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1128\/AEM.60.8.2779-2785.1994","volume":"60","author":"Chow","year":"1994","journal-title":"Applied and Environmental Microbiology","ISSN":"https:\/\/id.crossref.org\/issn\/0099-2240","issn-type":"print"},{"issue":"9","key":"7_36619896","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1021\/bi1000596","volume":"49","author":"Cockburn","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"8_28829433","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/bj3150467","volume":"315","year":"1996","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"9_38220875","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1021\/bi00007a016","volume":"34","year":"1995","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"1","key":"11_4782083","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0003-2697(79)80122-0","volume":"93","author":"Ellman","year":"1979","journal-title":"Analytical biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0003-2697","issn-type":"print"},{"issue":"20","key":"12_9990350","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1128\/jb.174.20.6368-6376.1992","volume":"174","author":"Fernandez-Abalos","year":"1992","journal-title":"Journal of Bacteriology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"13_39044170","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1021\/bi972232p","volume":"37","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"14_39044171","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1021\/bi972231x","volume":"37","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"15_23832660","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1096-987X(199802)19:3<319::AID-JCC6>3.0.CO;2-W","volume":"19","year":"1998","journal-title":"J COMP CHEM"},{"issue":"2","key":"16_9680618","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1432-1033.1991.tb16384.x","volume":"202","author":"Gilkes","year":"1991","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"issue":"suppl_2","key":"17_18952254","doi-asserted-by":"publisher","first-page":"W368","DOI":"10.1093\/nar\/gki464","volume":"33","author":"Gordon","year":"2005","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"9","key":"18_10968783","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1110\/ps.8.9.1843","volume":"8","author":"Grimsley","year":"1999","journal-title":"Protein Science","ISSN":"https:\/\/id.crossref.org\/issn\/0961-8368","issn-type":"print"},{"key":"19_33875424","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/1522-2683","issn-type":"print"},{"issue":"1","key":"20_19328558","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bpc.2005.04.004","volume":"117","author":"Haque","year":"2005","journal-title":"Biophysical chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0301-4622","issn-type":"print"},{"issue":"14","key":"21_34278457","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1073\/pnas.0901417106","volume":"106","year":"2009","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"22_39044172","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1021\/bi00175a041","volume":"33","year":"1994","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"23_30086758","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1021\/bi9905819","volume":"38","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"6","key":"24_22205749","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1128\/AEM.02612-05","volume":"72","author":"Kim","year":"2006","journal-title":"Applied and Environmental Microbiology","ISSN":"https:\/\/id.crossref.org\/issn\/0099-2240","issn-type":"print"},{"issue":"8","key":"25_16467798","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/protein\/9.8.691","volume":"9","author":"Koivula","year":"1996","journal-title":"Protein Engineering Design and Selection","ISSN":"https:\/\/id.crossref.org\/issn\/1741-0126","issn-type":"print"},{"issue":"34","key":"26_17203186","doi-asserted-by":"publisher","first-page":"10015","DOI":"10.1021\/ja012659q","volume":"124","author":"Koivula","year":"2002","journal-title":"Journal of the American Chemical Society","ISSN":"https:\/\/id.crossref.org\/issn\/1520-5126","issn-type":"print"},{"issue":"21","key":"27_29392157","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","year":"2007","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"28_34822122","doi-asserted-by":"crossref","first-page":"12915","DOI":"10.1021\/bi0506730","volume":"44","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"6","key":"29_21610878","first-page":"892","volume":"21","author":"Liu","year":"2005","journal-title":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1000-3061","issn-type":"print"},{"key":"30_30086759","doi-asserted-by":"crossref","first-page":"16419","DOI":"10.1021\/bi992271w","volume":"38","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"5","key":"31_22559370","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bioeng.2006.06.004","volume":"23","author":"Makde","year":"2006","journal-title":"Biomolecular engineering","ISSN":"https:\/\/id.crossref.org\/issn\/1389-0344","issn-type":"print"},{"issue":"3","key":"32_15583531","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1365-2958.1994.tb01030.x","volume":"12","author":"Meinke","year":"1994","journal-title":"Molecular microbiology","ISSN":"https:\/\/id.crossref.org\/issn\/0950-382X","issn-type":"print"},{"issue":"2","key":"33_19524499","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)71980-7","volume":"153","author":"Nelson","year":"1944","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"34_39044173","first-page":"889","volume":"34","year":"1999","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"key":"35_39044174","first-page":"505","volume":"114","year":"2001","journal-title":"Protein Engineering Design and Selection","ISSN":"https:\/\/id.crossref.org\/issn\/1741-0126","issn-type":"print"},{"issue":"3","key":"36_7943919","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0005-2736(79)90407-3","volume":"555","author":"Palmieri","year":"1979","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"4","key":"37_19486212","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1263\/jbb.99.434","volume":"99","author":"Park","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1347-4421","issn-type":"print"},{"issue":"4","key":"38_37033676","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","volume":"5","author":"Roy","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1750-2799","issn-type":"print"},{"issue":"2","key":"39_17231406","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0003-9861(02)00367-3","volume":"405","author":"Runquist","year":"2002","journal-title":"Archives of Biochemistry and Biophysics","ISSN":"https:\/\/id.crossref.org\/issn\/1096-0384","issn-type":"print"},{"issue":"6130","key":"40_14215487","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/328496a0","volume":"328","author":"Russell","year":"1987","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"17","key":"41_9468910","doi-asserted-by":"crossref","first-page":"11335","DOI":"10.1016\/S0021-9258(18)99167-2","volume":"266","author":"Shen","year":"1991","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"1-3","key":"42_5764937","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0168-1656(97)00090-4","volume":"57","author":"Sch\u00a0\u00a0lein","year":"1997","journal-title":"Journal of Biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1873-4863","issn-type":"print"},{"issue":"1","key":"43_2987049","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0021-9258(19)50870-5","volume":"195","author":"Somogyi","year":"1952","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"44_30086762","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/bi992091m","volume":"39","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"45_30719478","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1021\/bi00089a006","volume":"32","year":"1993","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"6143","key":"46_14293420","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/330086a0","volume":"330","author":"Sternberg","year":"1987","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"47_28682783","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/318375a0","volume":"318","year":"1985","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"48_39044175","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1021\/bi00815a015","volume":"9","year":"1970","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"2","key":"49_23441462","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1110\/ps.062538707","volume":"16","year":"2007","journal-title":"Protein Science","ISSN":"https:\/\/id.crossref.org\/issn\/0961-8368","issn-type":"print"},{"issue":"2","key":"50_17050486","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S0167-4838(01)00308-9","volume":"1596","author":"Tuohy","year":"2002","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"7","key":"51_15572410","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/bip.360340708","volume":"34","author":"Urry","year":"1994","journal-title":"Biopolymers","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3525","issn-type":"print"},{"issue":"21","key":"52_19574594","doi-asserted-by":"publisher","first-page":"20181","DOI":"10.1074\/jbc.C500142200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"53_39044176","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1021\/bi9802667","volume":"37","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"14","key":"54_35072698","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1111\/j.1742-4658.2009.07097.x","volume":"276","author":"Vuong","year":"2009","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"issue":"21","key":"55_35520128","doi-asserted-by":"publisher","first-page":"6655","DOI":"10.1128\/AEM.01260-09","volume":"75","year":"2009","journal-title":"Applied and Environmental Microbiology","ISSN":"https:\/\/id.crossref.org\/issn\/0099-2240","issn-type":"print"},{"issue":"1-3","key":"56_18830680","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bioeng.2004.10.003","volume":"22","author":"Wang","year":"2005","journal-title":"Biomolecular engineering","ISSN":"https:\/\/id.crossref.org\/issn\/1389-0344","issn-type":"print"},{"key":"57_39044177","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1021\/bi990401v","volume":"38","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"58_30112237","doi-asserted-by":"crossref","first-page":"10095","DOI":"10.1021\/bi034954o","volume":"42","year":"2003","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"key":"59_38220879","first-page":"315","volume":"44","year":"1986","ISSN":"https:\/\/id.crossref.org\/issn\/1879-0038","issn-type":"print"},{"issue":"1-3","key":"60_5764939","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0168-1656(97)00093-X","volume":"57","author":"Zhang","year":"1997","journal-title":"Journal of Biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1873-4863","issn-type":"print"},{"issue":"1","key":"61_6404978","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1046\/j.1432-1327.2000.00988.x","volume":"267","author":"Zhang","year":"2000","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"issue":"11","key":"62_10328214","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1046\/j.1432-1327.2000.01315.x","volume":"267","author":"Zhang","year":"2000","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"issue":"14","key":"63_18289179","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1093\/nar\/gnh110","volume":"32","author":"Zheng","year":"2004","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"}],"container-title":["Protein Engineering Design and Selection"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/peds\/article-pdf\/24\/5\/429\/4368374\/gzr004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T04:42:27Z","timestamp":1637210547000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/peds\/article-lookup\/doi\/10.1093\/protein\/gzr004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,27]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,4,15]]},"published-print":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/protein\/gzr004","relation":{},"ISSN":["1741-0126","1741-0134"],"issn-type":[{"value":"1741-0126","type":"print"},{"value":"1741-0134","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,27]]}}}