{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:48:41Z","timestamp":1771336121224,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":7809,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Poultry Science"],"published-print":{"date-parts":[[1998,6]]},"DOI":"10.1093\/ps\/77.6.812","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T18:42:48Z","timestamp":1391712168000},"page":"812-819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks"],"prefix":"10.1016","volume":"77","author":[{"given":"MA","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Brake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PB","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"WM","family":"Hagler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nesheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ps\/77.6.812_bib1","series-title":"Sister Chromatid Exchanges","first-page":"509","article-title":"Sister chromatid exchange studies in the chick embryo and neonate: actions of mutagens in a developing system","author":"Bloom","year":"1984"},{"key":"10.1093\/ps\/77.6.812_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0041-008X(76)90282-9","article-title":"The role of aflatoxin metabolism in its toxic lesion","volume":"35","author":"Campbell","year":"1976","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1093\/ps\/77.6.812_bib3","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1128\/aem.56.11.3482-3484.1990","article-title":"Effect of aflatoxins on rat peritoneal macrophages","volume":"56","author":"Cusumano","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/em.2860070510","article-title":"Embryonic exposure to aflatoxin-B1: Mutagenicity and influence on development and immunity","volume":"7","author":"Dietert","year":"1985","journal-title":"Environ. Mutagen."},{"key":"10.1093\/ps\/77.6.812_bib5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2460\/ajvr.1973.34.06.819","article-title":"Effect of aflatoxin B1 on resistance in poultry against cecal coccidiosis and Marek's disease","volume":"34","author":"Edds","year":"1973","journal-title":"Am. J. Vet. Res."},{"key":"10.1093\/ps\/77.6.812_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0165-2427(91)90138-3","article-title":"Suppression of cell-mediated immunity by purified aflatoxin B1 in broiler chicks","volume":"28","author":"Ghosh","year":"1991","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1093\/ps\/77.6.812_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2460\/ajvr.1978.39.02.305","article-title":"Effect of aflatoxin on the humoral and cell-mediated immune systems of the chicken","volume":"39","author":"Giambrone","year":"1978","journal-title":"Am. J. Vet. Res."},{"key":"10.1093\/ps\/77.6.812_bib8","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1084\/jem.132.1.134","article-title":"Transfer of antibody production with cells from the bursa of Fabricius","volume":"132","author":"Gilmour","year":"1970","journal-title":"J. Exp. Med."},{"key":"10.1093\/ps\/77.6.812_bib9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/carcin\/7.7.1101","article-title":"Correlation between induction of xenobiotic metabolism and DNA damage from chemical carcinogens in the chick embryo in vivo","volume":"7","author":"Hamilton","year":"1986","journal-title":"Carcinogenesis"},{"key":"10.1093\/ps\/77.6.812_bib10","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3382\/ps.0501880","article-title":"A natural and extremely severe occurrence of aflatoxicosis in laying hens","volume":"50","author":"Hamilton","year":"1971","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3382\/ps.0500800","article-title":"Aflatoxin as a possible cause of fatty liver syndrome in laying hens","volume":"50","author":"Hamilton","year":"1971","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib12","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.3382\/ps.0702425","article-title":"Interaction of naturally occurring aflatoxins in poultry feed and immunization against fowl cholera","volume":"70","author":"Hegazy","year":"1991","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib13","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1128\/aem.31.5.680-684.1976","article-title":"Effect of dietary aflatoxin on fertility, hatchability, and progeny performance of broiler breeder hens","volume":"31","author":"Howarth","year":"1976","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/aem.40.1.102-107.1980","article-title":"Evaluation of bone strength during aflatoxicosis and ochratoxicosis","volume":"40","author":"Huff","year":"1980","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3382\/ps.0610861","article-title":"Association of low levels of aflatoxin in feed with productivity losses in commercial broiler operations","volume":"61","author":"Jones","year":"1982","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib16","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/0006-2952(87)90224-3","article-title":"Ontogeny of the chicken P-450 enzyme system","volume":"36","author":"Lorr","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1093\/ps\/77.6.812_bib17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJM198709103171107","article-title":"Current concepts: Immunology. Neutrophils in human diseases","volume":"317","author":"Malech","year":"1987","journal-title":"NEJM"},{"key":"10.1093\/ps\/77.6.812_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0008-8749(73)90097-X","article-title":"Immunocompetent cells in chicken. II. Synergism between thymus cells and either bone marrow or bursal cells in the humoral immune response to sheep erythrocytes","volume":"8","author":"McArthur","year":"1973","journal-title":"Cell. Immunol."},{"key":"10.1093\/ps\/77.6.812_bib19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3382\/ps.0590669","article-title":"The effect of aging on immune competence in chicken: Antibody-mediated immunity","volume":"59","author":"McCorkle","year":"1980","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/02652038709373649","article-title":"HPLC determination of the total content of aflatoxins in naturally contaminated eggs in free and conjugated forms","volume":"4","author":"Micco","year":"1987","journal-title":"Food Addit. Contam."},{"key":"10.1093\/ps\/77.6.812_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0145-305X(92)90018-8","article-title":"Effects of AFB1 embryonic exposure on chicken mononuclear phagocytic cell functions","volume":"16","author":"Neldon-Ortiz","year":"1992","journal-title":"Develop. Comp. Immunol."},{"key":"10.1093\/ps\/77.6.812_bib22","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3382\/ps.0741970","article-title":"Avian hematopoiesis in response to avian cytokines","volume":"74","author":"Nicolas-Bolnet","year":"1995","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2307\/1588651","article-title":"The effect of aflatoxin on immunity in turkeys to bacterial challenge","volume":"14","author":"Pier","year":"1970","journal-title":"Avian Dis."},{"key":"10.1093\/ps\/77.6.812_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/em.2850210112","article-title":"Selective aflatoxin B1-induced sister chromatid exchanges and cytotoxicity in differentiating B and T lymphocytes in vivo","volume":"21","author":"Potchinsky","year":"1993","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1093\/ps\/77.6.812_bib25","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3181\/00379727-181-42293","article-title":"Genetic variation in the recruitment and activation of chicken peritoneal macrophages","volume":"181","author":"Qureshi","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1093\/ps\/77.6.812_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3382\/ps.0710104","article-title":"Effect of fumonisin B1 exposure on chicken macrophage functions in vitro","volume":"71","author":"Qureshi","year":"1992","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jat.2550100404","article-title":"Effects of aflatoxin on lymphoid cells of weanling rats","volume":"10","author":"Raisuddin","year":"1990","journal-title":"J. Appl. Toxicol."},{"key":"10.1093\/ps\/77.6.812_bib28","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","article-title":"Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2,7-dichlorofluorescin","volume":"47","author":"Rothe","year":"1990","journal-title":"J. Leuk. Biol."},{"key":"10.1093\/ps\/77.6.812_bib29","series-title":"SAS\u00ae User's Guide: Statistics. Version 6 Edition","author":"SAS Institute","year":"1990"},{"key":"10.1093\/ps\/77.6.812_bib30","series-title":"Official Methods of Analysis. The Association of Official Analytical Chemists International","first-page":"25","article-title":"Natural toxins AOAC official method 978.15, aflatoxin B1 in eggs, Chapter 49","author":"Scott","year":"1995"},{"key":"10.1093\/ps\/77.6.812_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/am.14.3.425-428.1966","article-title":"Production of aflatoxin on rice","volume":"14","author":"Shotwell","year":"1966","journal-title":"Appl. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3382\/ps.0490207","article-title":"Aflatoxicosis in the broiler chickens","volume":"49","author":"Smith","year":"1970","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib33","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3382\/ps.0530721","article-title":"Immunosuppression in chickens by aflatoxin","volume":"53","author":"Thaxton","year":"1974","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/em.2860020402","article-title":"Differential induction of sister chromatid exchanges by indirect-acting mutagen-carcinogens at early and late stages of embryonic development","volume":"2","author":"Todd","year":"1980","journal-title":"Environ. Mutagen."},{"key":"10.1093\/ps\/77.6.812_bib35","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3382\/ps.0622176","article-title":"Aflatoxicol and aflatoxin B1 and M1 in eggs and tissues of laying hens consuming aflatoxin-contaminated feed","volume":"62","author":"Trucksess","year":"1983","journal-title":"Poultry Sci."},{"key":"10.1093\/ps\/77.6.812_bib36","first-page":"317","article-title":"Determination of aflatoxicol, aflatoxins B1 and M1 in eggs","volume":"67","author":"Trucksess","year":"1984","journal-title":"J. Assoc. Offic. Anal. Chem."},{"key":"10.1093\/ps\/77.6.812_bib37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1128\/aem.40.3.641-645.1980","article-title":"Intestinal fragility during ochratoxicosis and aflatoxicosis in broiler chickens","volume":"40","author":"Warren","year":"1980","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1537-2995.1966.tb04696.x","article-title":"A simple hemagglutination system requiring small amounts of cells and antibodies","volume":"6","author":"Wegman","year":"1966","journal-title":"Transfusion"},{"key":"10.1093\/ps\/77.6.812_bib39","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/am.25.6.1018-1019.1973","article-title":"Improved yield of aflatoxin by incremental increases of temperature","volume":"25","author":"West","year":"1973","journal-title":"Appl. Microbiol."},{"key":"10.1093\/ps\/77.6.812_bib40","series-title":"Methods in Cancer Research","first-page":"309","article-title":"Aflatoxin carcinogens","author":"Wogan","year":"1973"}],"container-title":["Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119408857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0032579119408857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ps\/article-pdf\/77\/6\/812\/4341155\/poultrysci77-0812.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T21:22:34Z","timestamp":1758489754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0032579119408857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["S0032579119408857"],"URL":"https:\/\/doi.org\/10.1093\/ps\/77.6.812","relation":{},"ISSN":["0032-5791"],"issn-type":[{"value":"0032-5791","type":"print"}],"subject":[],"published":{"date-parts":[[1998,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks","name":"articletitle","label":"Article Title"},{"value":"Poultry Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ps\/77.6.812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Poultry Science Association Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}