{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:16:45Z","timestamp":1780568205915,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":147,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aimed to evaluate the relationship between cerebral white matter quantitative anomalies and postoperative clinical outcomes in patients with drug-resistant epilepsies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Automatic fiber quantification methodology was used to determine the diffusional anomalies in cerebral white matter tracts, from eight patients with frontal lobe epilepsy (FLE) and 12 with temporal lobe epilepsy (TLE) candidates and\/or undergoing epilepsy surgery. We studied the fractional anisotropy (FA), mean diffusivity (MD), volume (Vol), and number of fibers (Fib) of white matter tracts related to the physiopathologic mechanism of these epilepsies. The information was compared with that obtained from 19 healthy controls and between patients with seizure freedom and those with seizure recurrence 1 year after epilepsy surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Significant pre- and postsurgical global and segmental abnormalities were characterized by increased MD and decreased FA, Vol, and Fib in tracts from both hemispheres. TLE patients with postsurgical seizure freedom had preoperative increased global MD of the contralateral inferior longitudinal fasciculus and uncinate fasciculus. Furthermore, drug-resistant epilepsy patients with seizure freedom had a presurgical segmental increased MD in the contralateral thalamic radiation. Additionally, FLE patients with seizure freedom exhibited postsurgical increases in the Fib of the ipsilateral thalamic radiation and contralateral inferior longitudinal fasciculus. Furthermore, temporal lobe epilepsy patients with seizure freedom had a postsurgical lower global MD in the ipsilateral inferior fronto-occipital fasciculus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with drug-resistant epilepsies have global and segmental quantitative white matter tract anomalies, which suggests cerebral neural involvement in this disease. These abnormalities can vary regarding the postsurgical clinical outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/psyrad\/kkaf015","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T16:01:28Z","timestamp":1748448088000},"source":"Crossref","is-referenced-by-count":2,"title":["White matter quantitative anomalies and clinical outcome in drug-resistant epilepsies"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-5247","authenticated-orcid":false,"given":"Edwin Humberto","family":"Hodelin\u00a0Maynard","sequence":"first","affiliation":[{"name":"Transilvania University of Brasov, Faculty of Medicine, Transilvania Neurogenetic , Bra\u0219ov, PC 500019 ,","place":["Romania"]},{"name":"International Centre of Neurological Restoration , Neurosurgery Department, Havana, PC 11300 ,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-5899","authenticated-orcid":false,"given":"Nelson Ernesto","family":"Quintanal\u00a0Cordero","sequence":"additional","affiliation":[{"name":"CENIT Foundation for Research in Neurosciences, Autonomous City of Buenos Aires , PC C1125ABD ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenaida Milagros","family":"Hern\u00e1ndez\u00a0D\u00edaz","sequence":"additional","affiliation":[{"name":"International Centre of Neurological Restoration , Diagnostic Department, Havana, PC 11300 ,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Caridad","family":"R\u00edos\u00a0Castillo","sequence":"additional","affiliation":[{"name":"International Centre of Neurological Restoration , Neurosurgery Department, Havana, PC 11300 ,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Mar\u00eda","family":"Morales\u00a0Chac\u00f3n","sequence":"additional","affiliation":[{"name":"International University of Rioja , Neuropsychology and Education Department, Logro\u00f1o, PC 26006 ,","place":["Spain"]},{"name":"Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China , Chengdu, PC 610218 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2025061311414690200_bib1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-27233-4","article-title":"White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis","volume":"13","author":"Barto\u0148ov\u00e1","year":"2023","journal-title":"Sci Rep"},{"key":"2025061311414690200_bib2","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/epi.15612","article-title":"Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: a consensus report from the International League Against Epilepsy Neuroimaging Task Force","volume":"60","author":"Bernasconi","year":"2019","journal-title":"Epilepsia"},{"key":"2025061311414690200_bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1167.2011.03298.x","article-title":"Subtypes of medial temporal lobe epilepsy: influence on temporal lobectomy outcomes?","volume":"53","author":"Bonilha","year":"2012","journal-title":"Epilepsia"},{"key":"2025061311414690200_bib4","first-page":"615.e1","article-title":"Palliative procedures for drug-resistant epilepsy","volume-title":"Youmans & Winn Neurological Surgery","author":"Brahimaj","year":"2023"},{"key":"2025061311414690200_bib5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/epi.12871","article-title":"White matter abnormalities associate with type and localization of focal epileptogenic lesions","volume":"56","author":"Campos","year":"2015","journal-title":"Epilepsia"},{"key":"2025061311414690200_bib6","first-page":"36","article-title":"Anatom\u00eda macrosc\u00f3pica del enc\u00e9falo","volume-title":"Neuroanatom\u00eda. 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