{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:30:36Z","timestamp":1791851436707,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late-life depression (LLD) and odor identification (OI) dysfunction are risk factors for dementia, but the underlying neural mechanisms remain unclear. This study investigated dynamic functional connectivity (dFC) in olfactory brain regions of LLD patients with and without OI dysfunction and examined how dFC moderates the OI\u2013cognition link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting-state functional magnetic resonance imaging data were acquired from 51 LLD patients with OI deficits (LLD-OID), 59 LLD patients without deficits (LLD-noOID), and 51 healthy controls (HC). A sliding-window approach (50 TR width, 1 TR step) was used to estimate dFC variability between the orbitofrontal cortex (OFC) and the whole brain. Bayesian regression and moderation analyses assessed associations among OFC dFC, OI scores, and cognitive measures. Results were robust across window sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to LLD-noOID and HC, LLD-OID showed decreased OFC\u2013left inferior frontal gyrus dFC variability (P\u00a0&amp;lt;\u00a00.01) and increased OFC\u2013right middle frontal gyrus (MFG) variability (P\u00a0&amp;lt;\u00a00.001). Higher OFC\u2013MFG variability was associated with worse OI and cognitive performance and significantly moderated the OI\u2013global cognition relationship (\u03b2 = 1.06, P\u00a0=\u00a00.027, 95% CI [0.12, 2.0]). No group differences were found in primary olfactory regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LLD patients with OI dysfunction exhibited more disrupted dFC in secondary olfactory regions compared with those without OI dysfunction. Dynamic OFC\u2013MFG disconnectivity may index vulnerability to cognitive decline and dementia risk in LLD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/psyrad\/kkag002","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:51:01Z","timestamp":1770900661000},"source":"Crossref","is-referenced-by-count":1,"title":["Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression"],"prefix":"10.1093","volume":"6","author":[{"given":"Ben","family":"Chen","sequence":"first","affiliation":[{"name":"The Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou , , 510370","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou , 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