{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:05:56Z","timestamp":1793243156771,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Norwegian Fund for Postgraduate Training in Physiotherapy","award":["1\/370\u201300\/09"],"award-info":[{"award-number":["1\/370\u201300\/09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Despite the risk of delayed motor development in infants born preterm, knowledge about interventions in the neonatal intensive care unitt (NICU) and the effects of dosing is sparse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objectives of this study were to examine the effectiveness of a parent-administered exercise program in the NICU on motor outcome at 3\u00a0months corrected age (CA) and the effect of dosing on motor performance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This was a randomized clinical trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The study was conducted at 3 university hospitals in Troms\u00f8, Trondheim, and Oslo, Norway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A total of 153 infants with gestational age\u00a0&amp;lt;32\u00a0weeks at birth were randomly assigned to intervention or control groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>A 3-week parent-administered intervention designed to facilitate movements in preterm infants was performed in the NICU. Parents were asked to administer the intervention 10\u00a0minutes twice a day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Measurements<\/jats:title>\n                  <jats:p>Test of Infant Motor Performance (TIMP) was used to assess short-term outcome at 3\u00a0months CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No significant difference in the TIMP z-score was found between intervention and control groups at follow-up 3\u00a0months CA, but a significant positive relationship was found between total intervention dose and TIMP z-scores. The adjusted odds of having a clinical z-score\u00a0&amp;lt;\u00a00 at 3\u00a0months CA was about 6 times higher for infants with less than median intervention time than for infants with a longer intervention time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>The number of infants born before 28\u00a0weeks was small. A spillover effect in favor of the control group was possible. We do not know if the infants received physical therapy after discharge from the hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There was no difference in motor performance between the intervention group and the control group at 3\u00a0months CA. However, an increased intervention dose was positively associated with improved motor outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzaa014","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T12:23:56Z","timestamp":1578572636000},"page":"860-869","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a Parent-Administered Exercise Program in the Neonatal Intensive Care Unit: Dose Does Matter\u2014A Randomized Controlled Trial"],"prefix":"10.1093","volume":"100","author":[{"given":"Gunn Kristin","family":"\u00d8berg","sequence":"first","affiliation":[{"name":"Department of Health and Care Sciences , Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, PB 6050 Langnes, Troms\u00f8, 9037 Norway; and Department of Clinical Therapeutic Services, University Hospital North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gay L","family":"Girolami","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , College of Applied Health Sciences, University of Illinois at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzann K","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tordis","family":"Ustad","sequence":"additional","affiliation":[{"name":"Department of Clinical Services , St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar","family":"Heuch","sequence":"additional","affiliation":[{"name":"Department of Mathematics , University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne K","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Community Medicine , Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway; and Centre for Sami Health Research, Department of Community Medicine, University of Troms\u00f8, The Arctic University of Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Ivar","family":"Kaaresen","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Department , University Hospital North Norway; and Department of Clinical Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke Smith","family":"Aulie","sequence":"additional","affiliation":[{"name":"Section of Physiotherapy , Oslo University Hospital, Ullev\u00e5l, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Health and Care Sciences , Faculty of Health Sciences, University of 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