{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:25:05Z","timestamp":1767007505858},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"State of Piau\u00ed Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Although some studies have shown the clinical benefits of therapeutic exercise in chronic nonspecific low back pain, the effect sizes are generally small to moderate and recurrence rates are high. Transcranial direct current stimulation (tDCS) has been used to modulate pain-processing systems and motor outputs and has the potential to optimize the clinical benefits of therapeutic exercise. However, evidence for this combination is still lacking. The purpose of this protocol for a randomized clinical trial is to investigate whether the combination of tDCS and therapeutic exercise is more effective in relieving pain than therapeutic exercise alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This 2-arm, randomized controlled clinical trial will take place at the Federal University of Piau\u00ed, Brazil. Sixty patients will be randomized into 2 groups to receive tDCS (real\/sham)\u00a0+\u00a0exercise therapies for 12 sessions over a period of 4\u00a0weeks. Pain intensity, sensory and affective aspects of pain, physical functioning, kinesiophobia, and global perceived effect will be recorded before treatment and at 4\u00a0weeks, 3\u00a0months, and 6\u00a0months after randomization. Data will be collected by an examiner unaware of (blind to) the treatment allocation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>This trial can potentially provide important information and assist in clinical decision-making on the combined use of tDCS to optimize the clinical benefits of therapeutic exercise in patients with chronic nonspecific low back pain.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzaa105","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T03:28:13Z","timestamp":1591673293000},"page":"1595-1602","source":"Crossref","is-referenced-by-count":4,"title":["Transcranial Direct Current Stimulation Combined With Therapeutic Exercise in Chronic Low Back Pain: Protocol of a Randomized Controlled Trial"],"prefix":"10.1093","volume":"100","author":[{"given":"Polyanna Gomes Lacerda","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Department of Physical Therapy , Biomedical Master Science Program, Universidade Federal do Piaui, Parna\u00edba, PI - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrah\u00e3o Fontes","family":"Baptista","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computation and Cognition , Universidade Federal do ABC, S\u00e3o Bernardo do Campo, SP - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Saura","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , Biomedical Master Science Program, Universidade Federal do Piaui"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo de Carvalho","family":"Filgueiras","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , Biomedical Master Science Program, Universidade Federal do Piaui"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Hydee","family":"Hasue","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , Communication Sciences and Disorders, and Occupational Therapy, Doctoral Programs in Rehabilitation Sciences, Faculdade de Medicina da Universidade de S\u00e3o Paulo - USP, S\u00e3o Paulo, SP - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Maria Amado","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , Communication Sciences and Disorders, and Occupational Therapy, Doctoral Programs in Rehabilitation Sciences, Faculdade de Medicina da Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad Ahmad","family":"Hazime","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy , Biomedical Master Science Program, Universidade Federal do Piaui, Parna\u00edba, Avenida S\u00e3o Sebasti\u00e3o, 2819, CEP: 64202-020 Parna\u00edba, PI - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"2023011804393987100_ref1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0140-6736(09)62164-4","article-title":"Group cognitive behavioural treatment for low-back pain in primary care: a randomised controlled trial and cost-effectiveness analysis","volume":"375","author":"Lamb","year":"2010","journal-title":"Lancet."},{"key":"2023011804393987100_ref2","article-title":"Brazilian Institute of Geography and Statistics (IBGE): National Sampling Study of Households. 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