{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:46:40Z","timestamp":1787312800219,"version":"build-2736575974"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The main goal of musculoskeletal rehabilitation is to achieve the pre-injury and\/or pre-surgery physical function level with a low risk of re-injury. Blood flow restriction (BFR) training is a promising alternative to conventional therapy approaches during musculoskeletal rehabilitation because various studies support its beneficial effects on muscle mass, strength, aerobic capacity, and pain perception. In this perspective article, we used an evidence-based progressive model of a rehabilitative program that integrated BFR in 4 rehabilitation phases: (1) passive BFR, (2) BFR combined with aerobic training, (3) BFR combined with low-load resistance training, and (4) BFR combined with low-load resistance training and traditional high-load resistance training. Considering the current research, we propose that a BFR-assisted rehabilitation has the potential to shorten the time course of therapy to reach the stage where the patient is able to tolerate resistance training with high loads. The information and arguments presented are intended to stimulate future research, which compares the time to achieve rehabilitative milestones and their physiological bases in each stage of the musculoskeletal rehabilitation process. This requires the quantification of BFR training-induced adaptations (eg, muscle mass, strength, capillary-to-muscle-area ratio, hypoalgesia, molecular changes) and the associated changes in performance with a high measurement frequency (\u22641 week) to test our hypothesis. This information will help to quantify the time saved by BFR-assisted musculoskeletal rehabilitation. This is of particular importance for patients, because the potentially accelerated recovery of physical functioning would allow them to return to their work and\/or social life earlier. Furthermore, other stakeholders in the health care system (eg, physicians, nurses, physical therapists, insurance companies) might benefit from that with regard to work and financial burden.<\/jats:p>","DOI":"10.1093\/ptj\/pzab172","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T07:46:51Z","timestamp":1625125611000},"source":"Crossref","is-referenced-by-count":17,"title":["Time to Save Time: Beneficial Effects of Blood Flow Restriction Training and the Need to Quantify the Time Potentially Saved by Its Application During Musculoskeletal Rehabilitation"],"prefix":"10.1093","volume":"101","author":[{"given":"Robert","family":"Bielitzki","sequence":"first","affiliation":[{"name":"Department of Sport Science, Institute III, Otto von Guericke University Magdeburg , Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Department of Sport Science, Institute III, Otto von Guericke University Magdeburg , Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department of Sport Science, Institute III, Otto von Guericke University Magdeburg , Magdeburg, Germany"},{"name":"Department of Orthopedics , University Medicine Rostock, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schega","sequence":"additional","affiliation":[{"name":"Department of Sport Science, Institute III, Otto von Guericke University Magdeburg , Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"2023011803094644000_ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jsams.2014.12.009","article-title":"Muscle atrophy contributes to quadriceps weakness after anterior cruciate ligament reconstruction","volume":"19","author":"Thomas","year":"2016","journal-title":"J Sports Sci Med"},{"key":"2023011803094644000_ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1556\/APhysiol.99.2012.3.1","article-title":"Blood flow restriction: an evidence based progressive model (review)","volume":"99","author":"Loenneke","year":"2012","journal-title":"Acta Physiol Hung"},{"key":"2023011803094644000_ref3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/rheumatology\/ken427","article-title":"Risk factors for the development of hip osteoarthritis: a population-based prospective study","volume":"48","author":"Juhakoski","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"2023011803094644000_ref4","doi-asserted-by":"crossref","first-page":"S336","DOI":"10.1016\/j.joca.2014.02.621","article-title":"Knee extensor muscle weakness increases the risk of knee osteoarthritis. 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