{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:46:12Z","timestamp":1761864372386,"version":"3.41.2"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria del Instituto de Salud Carlos III","award":["FI19\/00230"],"award-info":[{"award-number":["FI19\/00230"]}]},{"name":"Spanish Ministry of Education Cultura y Deporte","award":["FPU17\/00939","FPU18\/03575"],"award-info":[{"award-number":["FPU17\/00939","FPU18\/03575"]}]},{"name":"Ilustre Colegio Profesional de Fisioterapeutas de Andaluc\u00eda","award":["AI-04\/2020"],"award-info":[{"award-number":["AI-04\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This trial will analyze the acute and cumulative effects of a tailored program called PRESIONA that combines therapeutic exercise and blood flow restriction to prevent chemotherapy-induced peripheral neuropathy (CIPN) in individuals with early breast cancer undergoing neoadjuvant chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PRESIONA will be a physical therapist\u2013led multimodal exercise program that uses blood flow restriction during low-load aerobic and strength exercises. For the acute study, only 1 session will be performed 1\u00a0day before the first taxane cycle, in which 72 women will be assessed before intervention and 24\u00a0hours post intervention. For the cumulative study, PRESIONA will consist of 24 to 36 sessions for 12\u00a0weeks following an undulatory prescription. At least 80 women will be randomized to the experimental group or control group. Feasibility will be quantified based on the participant recruitment to acceptance ratio; dropout, retention, and adherence rates; participant satisfaction; tolerance; and program security. In the efficacy study, the main outcomes will be CIPN symptoms assessed with a participant-reported questionnaire (EORTC QLQ-CIPN20). In addition, to determine the impact on other participant-reported health and sensorimotor and physical outcomes, the proportion of completed scheduled chemotherapy sessions will be examined at baseline (t0), after anthracycline completion (t1), after intervention (t2), and at the 2-month (t3) and 1-year follow-ups (t4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The proposed innovative approach of this study could have a far-reaching impact on therapeutic options, and the physical therapist role could be essential in the oncology unit to improve quality of life in individuals with cancer and reduce side effects of cancer and its treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Physical therapists in the health care system could be essential to achieve the planned doses of chemotherapy to improve survival and decrease the side effects of individuals with breast cancer. The prevention of CIPN would have an impact on the quality of life in these individuals, and this protocol potentially could provide an action guide that could be implemented in any health care system.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzab282","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T12:08:35Z","timestamp":1639742915000},"source":"Crossref","is-referenced-by-count":4,"title":["Prevention of Chemotherapy-Induced Peripheral Neuropathy With PRESIONA, a Therapeutic Exercise and Blood Flow Restriction Program: A Randomized Controlled Study Protocol"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-9673","authenticated-orcid":false,"given":"Maria","family":"Lopez-Garzon","sequence":"first","affiliation":[{"name":"Health Sciences Faculty , University of Granada, Granada, Spain"},{"name":"\u2018Cu\u00eddate\u2019 From Biomedical Group (BIO277) , Instituto de Investigaci\u00f3n 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