{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:08:18Z","timestamp":1792786098561,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Funding for Longevity Sciences","award":["27\u201322"],"award-info":[{"award-number":["27\u201322"]}]},{"name":"NCGG, Grant-in-Aid for Scientific Research","award":["26242059"],"award-info":[{"award-number":["26242059"]}]},{"name":"Strategic Basic Research Programs Redesigning Communities for Aged Society"},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Labor Sciences Research Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of the study was to estimate, using an isotemporal substitution model, the effect of replacing sedentary behavior (SB) with physical activity on the incidence of disability in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 2-year longitudinal cohort study enrolled 3691 community-dwelling older adults (57.2% women; mean age\u2009=\u200974.0 [SD\u2009=\u20095.0] years). Individuals with dementia, stroke, Parkinson disease, depression, low Mini-Mental State Examination scores, dependence on basic activities of daily living, and missing data were excluded. Physical activity and potential confounding factors were investigated as a baseline survey of disability incidence, defined by Japanese long-term care insurance certification, for 2\u00a0years in 2 regions. Physical activity data (SB, light-intensity physical activity, and moderate- to vigorous-intensity physical activity [MVPA]) were measured using triaxial accelerometers for 14\u00a0days, and daily mean time spent in each physical activity parameter was computed in increments of 10\u00a0minutes. The relationship between baseline physical activity and disability incidence adjusted for potential confounders was analyzed using multilevel Cox proportional hazards regression analyses with an isotemporal substitution model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The disability incidence rate was 3.8%, excluding individuals who could not be followed-up. Replacing 10\u00a0minutes of SB per day with MVPA was associated with a decreased disability incidence (hazard ratio\u2009=\u20090.870; 95% CI\u2009=\u20090.766\u20130.988), whereas no evidence was found for replacing SB with light-intensity physical activity (hazard ratio\u2009=\u20090.980; 95% CI\u2009=\u20090.873\u20131.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Replacing SB with MVPA was associated with a lower risk of disability. These findings are helpful for establishing disability prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>These results suggest that feasible changes in daily behavior, such as replacing 10\u00a0minutes of SB with MVPA daily, might have a protective effect on disability incidence. Clarifying these associations is useful for developing disability prevention strategies and may help reduce the incidence of disability in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ptj\/pzac002","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T07:13:09Z","timestamp":1641885189000},"source":"Crossref","is-referenced-by-count":8,"title":["Isotemporal Substitution of Sedentary Behavior With Moderate to Vigorous Physical Activity Is Associated With Lower Risk of Disability: A Prospective Longitudinal Cohort Study"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-3595","authenticated-orcid":false,"given":"Ippei","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Preventive Gerontology , Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu,","place":["Japan"]},{"name":"Department of Medical Sciences 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Obu,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-8256","authenticated-orcid":false,"given":"Keitaro","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Preventive Gerontology , Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu,","place":["Japan"]},{"name":"Japan Society for the Promotion of Science, Chiyoda-ku , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Shinkai","sequence":"additional","affiliation":[{"name":"Department of Preventive Gerontology , Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Preventive Gerontology , Center for Gerontology and Social 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