{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:33:24Z","timestamp":1788863604341,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The purpose of this study was to assess the current evidence for the effects of neural mobilization (NM) treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Three umbrella reviews with meta\u2013meta-analyses were conducted to determine the effects of NM on pain intensity and disability in people with musculoskeletal disorders and on mechanosensitivity in participants who were asymptomatic. The study used the grading criteria proposed by the Physical Activity Guidelines Advisory Committee to assess the quality of evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One meta\u2013meta-analysis revealed a statistically significant moderate effect on pain intensity (standardized mean difference [SMD]\u2009=\u2009\u22120.75, 95% CI\u2009=\u2009\u22121.12 to \u22120.38) but with evidence of heterogeneity (Q\u2009=\u200914.13; I2\u2009=\u200965%). The study found a significantly large effect of NM on disability (SMD\u2009=\u2009\u22121.22, 95% CI\u2009=\u2009\u22122.19 to \u22120.26), again with evidence of heterogeneity (Q\u2009=\u200931.57; I2\u2009=\u200987%). The third meta\u2013meta-analysis showed a statistically significant moderate effect of NM on mechanosensitivity (SMD\u2009=\u20090.96, 95% CI\u2009=\u20090.35 to 1.57), with no evidence of heterogeneity (Q\u2009=\u20092.73; I2\u2009=\u200963%). For all examined outcomes, the quality of evidence was limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Overall, the results indicated that although NM treatment had a moderate to large beneficial clinical effect on pain intensity and disability in people with musculoskeletal disorders and on mechanosensitivity in individuals who were asymptomatic, the quality of evidence was limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Neural mobilization treatments showed positive results on the pain intensity and disability in individuals with musculoskeletal conditions. Neural mobilization could be integrated into the physical therapy management, although more research is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzac040","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:17:03Z","timestamp":1649935023000},"source":"Crossref","is-referenced-by-count":23,"title":["Effects of Neural Mobilization on Pain Intensity, Disability, and Mechanosensitivity: An Umbrella Review With Meta\u2013Meta-Analysis"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4644-3758","authenticated-orcid":false,"given":"Ferran","family":"Cuenca-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Physiotherapy , Exercise Intervention for Health Research Group (EXINH-RG), University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"La Touche","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia , Centro Superior de Estudios Universitarios La Salle, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"},{"name":"Motion in Brains Research Group , Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"},{"name":"Instituto de Neurociencia y Dolor Craneofacial (INDCRAN) , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-8013","authenticated-orcid":false,"given":"Clovis","family":"Varangot-Reille","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy , Exercise Intervention for Health Research Group (EXINH-RG), University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00ebva","family":"Sardinoux","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia , Centro Superior de Estudios Universitarios La Salle, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Bahier","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia , Centro Superior de Estudios Universitarios La Salle, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-4243","authenticated-orcid":false,"given":"Luis","family":"Suso-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy , Exercise Intervention for Health Research Group (EXINH-RG), University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"Fern\u00e1ndez-Carnero","sequence":"additional","affiliation":[{"name":"Motion in Brains Research Group , Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"},{"name":"Department of Physical Therapy , Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Madrid, Spain"},{"name":"Grupo Multidisciplinar de Investigaci\u00f3n y Tratamiento del Dolor Grupo de Excelencia Investigadora URJC-Banco de Santander , Rey Juan Carlos University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"2023011809395140500_ref1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0031-9406(05)67024-1","article-title":"Neurodynamics","volume":"81","author":"Shacklock","year":"1995","journal-title":"Physiotherapy"},{"key":"2023011809395140500_ref2","first-page":"26","article-title":"Efectividad de la movilizaci\u00f3n neurodin\u00e1mica en el dolor y funcionalidad en sujetos con s\u00edndrome del t\u00fanel carpiano: revisi\u00f3n sistem\u00e1tica","volume":"25","author":"Cornejo","year":"2018","journal-title":"Rev Soc Esp Dolor"},{"key":"2023011809395140500_ref3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1179\/106698108790818594","article-title":"Neural mobilization: a systematic review of randomized controlled trials with an analysis of therapeutic efficacy","volume":"16","author":"Ellis","year":"2008","journal-title":"J Man Manip Ther"},{"key":"2023011809395140500_ref4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.math.2006.12.008","article-title":"Do \u201csliders\u201d slide and \u201ctensioners\u201d tension? 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