{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:22Z","timestamp":1753877122454,"version":"3.41.2"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The nociceptive pain processing of soft-tissue overuse conditions is under debate because no consensus currently exists. The purpose of this meta-analysis was to compare pressure pain thresholds (PPTs) in symptomatic and distant pain-free areas in 2 groups: participants with symptomatic lower extremity overuse soft-tissue conditions and controls who were pain free.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Five databases were searched from inception to December 1, 2021, for case\u2013control studies comparing PPTs between individuals presenting with symptomatic lower extremity tendinopathy\/overuse injury and controls who were pain free. Data extraction included population, diagnosis, sample size, outcome, type of algometer, and results. The methodological quality (Newcastle-Ottawa Quality Assessment Scale) and evidence level (Grading of Recommendations Assessment, Development, and Evaluation) were assessed. Meta-analyses of symptomatic, segmental related, and distant pain-free areas were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After screening 730 titles and abstracts, a total of 19 studies evaluating lower extremity overuse conditions (Achilles or patellar tendinopathy, greater trochanteric pain syndrome, plantar fasciitis, and iliotibial band syndrome) were included. The methodological quality ranged from fair (32%) to good (68%). Participants with lower extremity overuse injury had lower PPTs in both the painful and nonpainful areas, mirrored test-site, compared with controls (affected side: mean difference [MD]\u2009=\u2009\u2212262.92\u00a0kPa, 95% CI\u2009=\u2009323.78 to \u2212202.05\u00a0kPa; nonaffected side: MD\u2009=\u2009\u2212216.47\u00a0kPa, 95% CI\u2009=\u2009\u2212304.99 to \u2212127.95\u00a0kPa). Furthermore, people with plantar fasciitis showed reduced PPTs in the affected and nonaffected sides at segmental-related (MD\u2009=\u2009\u2212176.39\u00a0kPa, 95% CI\u2009=\u2009\u2212306.11 to \u221246.68\u00a0kPa) and distant pain-free (MD\u2009=\u2009\u221297.27\u00a0kPa, 95% CI\u2009=\u2009133.21 to \u221261.33\u00a0kPa) areas compared with controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Low- to moderate-quality evidence suggests a reduction of PPTs at the symptomatic area and a contralateral\/mirror side in lower extremity tendinopathies and overuse conditions compared with pain-free controls, particularly in plantar fasciitis and greater trochanteric pain syndrome. Participants with plantar fasciitis showed a reduction of PPTs on the affected and non-affected sides at a segmental-related area (very low-quality evidence) and at a remote asymptomatic area (moderate-quality evidence).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Some overuse peripheral pain conditions may be more associated with pressure pain sensitivity than others. Accordingly, examination and identification of conditions more peripherally, centrally, or mixed mediated could potentially lead to more specific and different treatment strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzac119","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T08:49:40Z","timestamp":1663663780000},"source":"Crossref","is-referenced-by-count":2,"title":["A Closer Look at Localized and Distant Pressure Pain Hypersensitivity in People With Lower Extremity Overuse Soft-Tissue Painful Conditions: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"102","author":[{"given":"Gustavo","family":"Plaza-Manzano","sequence":"first","affiliation":[{"name":"Universidad Complutense de Madrid Radiology, Rehabilitation and Physiotherapy Department, , Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), Alcorc\u00f3n Department of Physical Therapy, , Madrid, Spain"},{"name":"Universidad Rey Juan Carlos C\u00e1tedra Institucionalen Docencia, Cl\u00ednica e Investigaci\u00f3nen Fisioterapia: Terapia Manual, Punci\u00f3n Seca y Ejercicio Terap\u00e9utico, , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A","family":"Cleland","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Doctor of Physical Therapy Program, , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L","family":"Arias-Bur\u00eda","sequence":"additional","affiliation":[{"name":"Universidad Complutense de Madrid Radiology, Rehabilitation and Physiotherapy Department, , Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-0402","authenticated-orcid":false,"given":"Dhinu J","family":"Jayaseelan","sequence":"additional","affiliation":[{"name":"The George Washington University Department of Health, Human Function and Rehabilitation Sciences, , Washington, DC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos J","family":"Navarro-Santana","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica de \u00c1vila (UCAV), Calle Canteros s\/n Faculty of Health, , \u00c1vila, Spain"},{"name":"Faculty of Health, Universidad Camilo Jos\u00e9 Cela VALTRADOFI Research Group, Department of Physiotherapy, , Villanueva de la Ca\u00f1ada , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"2023083119041445400_ref1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s40279-013-0124-z","article-title":"Definition and usage of the term \u201coveruse injury\u201d in the US high school and collegiate sport epidemiology literature: a systematic review","volume":"44","author":"Roos","year":"2014","journal-title":"Sports Med"},{"key":"2023083119041445400_ref2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12891-016-0885-2","article-title":"Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study","volume":"17","author":"Albers","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"2023083119041445400_ref3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/bjsports-2015-095422","article-title":"Revisiting the 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