{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:52:56Z","timestamp":1788965576564,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Capri Cardiac Rehabilitation"},{"name":"Dutch Organisation for Health Research and Development","award":["843001792"],"award-info":[{"award-number":["843001792"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Previously published results of the OPTICARE XL open label randomized controlled trial showed no added value of OPTICARE XL CR, a dedicated cardiac rehabilitation (CR) program for patients with obesity, with respect to health\u2013related quality of life (primary outcome). This clinical trial studied the effects of OPTICARE XL CR on several secondary outcomes, which included body weight, physical activity, sedentary behavior, and physical fitness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with coronary artery disease or atrial fibrillation and body mass index \u2265\u200930 were randomized to OPTICARE XL CR (n\u00a0=\u2009102) or standard CR (n\u00a0=\u200999). OPTICARE XL CR was a 1-year group intervention, specifically designed for patients with obesity that included aerobic and strength exercise, behavioral coaching, and an aftercare program. Standard CR consisted of a 6- to 12-week group aerobic exercise program, supplemented with cardiovascular lifestyle education. Study end points included body weight, physical activity, sedentary behavior (accelerometer), and physical fitness (6-Minute Walk Test and handgrip strength), which were evaluated 6\u00a0months after the end of CR (primary endpoint) and 3\u00a0months after the start of CR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Six months after completion of either program, improvements in body weight, physical activity, sedentary behavior, and physical fitness were similar between the groups. Three months after CR start, patients randomized to OPTICARE XL CR showed greater weight loss (mean change\u2009=\u2009\u22123.6 vs \u22121.8\u00a0kg) and a larger improvement in physical activity (+880 vs +481 steps per day) than patients randomized to standard CR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients allocated to OPTICARE XL CR lost significantly more body weight and showed promising results with respect to physical activity 3\u00a0months after the start of CR; however, these short-term results were not expanded or sustained in the longer term.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Patients with obesity do not benefit from standard CR programs. The new OPTICARE XL CR program showed its effects in the short term on weight loss and physical activity, and, therefore, redesign of the aftercare phase is recommended.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzad055","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T23:06:20Z","timestamp":1685747180000},"source":"Crossref","is-referenced-by-count":15,"title":["Effects of a Dedicated Cardiac Rehabilitation Program for Patients With Obesity on Body Weight, Physical Activity, Sedentary Behavior, and Physical Fitness: The OPTICARE XL Randomized Controlled Trial"],"prefix":"10.1093","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-7684","authenticated-orcid":false,"given":"Iris","family":"den Uijl","sequence":"first","affiliation":[{"name":"Erasmus University Medical Centre Department of Rehabilitation Medicine, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita J G","family":"van den Berg-Emons","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Rehabilitation Medicine, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Sunamura","sequence":"additional","affiliation":[{"name":"Capri Cardiac Rehabilitation , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattie J","family":"Lenzen","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Cardiology, Thoraxcenter, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J","family":"Stam","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Rehabilitation Medicine, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Cardiology, Thoraxcenter, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C C W","family":"Tenb\u00fclt-van Limpt","sequence":"additional","affiliation":[{"name":"M\u00e1xima Medical Centre Department of Cardiology, , Eindhoven\/Veldhoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareld M C","family":"Kemps","sequence":"additional","affiliation":[{"name":"M\u00e1xima Medical Centre Department of Cardiology, , Eindhoven\/Veldhoven, the Netherlands"},{"name":"Eindhoven University of Technology Department of Industrial Design, , Eindhoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel L","family":"Geleijnse","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Cardiology, Thoraxcenter, , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"ter Hoeve","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Centre Department of Rehabilitation Medicine, , Rotterdam, the Netherlands"},{"name":"Capri Cardiac Rehabilitation , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"2023090416302239700_ref1","volume-title":"Multidisciplinary Guidelines Cardiac Rehabilitation (Multidisciplinaire Richtlijn Hartrevalidatie 2011)","author":"Revalidatiecommissie NVVC \/ NHS en projectgroep PAAHR","year":"2011"},{"key":"2023090416302239700_ref2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 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