{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:29:22Z","timestamp":1784903362186,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fundo de Incentivo \u00e0 Pesquisa e Eventos do Hospital de Cl\u00ednicas de Porto Alegre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to evaluate the impact of intensive care unit (ICU)-acquired weakness (ICUAW) on the functional independence of patients hospitalized for coronavirus disease 2019 (COVID-19) over 6\u00a0months after ICU discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective cohort study that included patients who were admitted to the ICU because of COVID-19 and who were monitored for 6\u00a0months after discharge from the ICU via telephone. Patients were evaluated at 3 times (30\u00a0days, 3\u00a0months, and 6\u00a0months after discharge from the ICU) for functional independence for personal care and mobility activities (Barthel Scale), independence for self-care (Katz Index), impact of COVID-19 on functional status (post\u2013COVID-19 Functional Status Scale [PCFS]), and mobility level (ICU Mobility Scale). The existence of some degree of dependence was considered when the Barthel Scale score was &amp;lt;100 points, the Katz Index was \u22651, and the PCFS score was \u22651. A PCFS score of \u22653 indicated moderate or severe dependence. Patients with a Medical Research Council score of &amp;lt;48 at discharge from the ICU were diagnosed with ICUAW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixty-eight patients were included, with a mean age of 51 (SD\u2009=\u200913) years. The ICUAW rate at ICU discharge was 35%. In the evaluation with the PCFS, the values for the presence of any functional limitation at 30\u00a0days, 3\u00a0months, and 6\u00a0months after ICU discharge were 89.7%, 57.4%, and 38.2%, respectively. The rate of persistence of functional limitations after 6\u00a0months was higher in patients with ICUAW than in those without ICUAW (66.7% vs 22.8%; P\u2009=\u2009.000); the same was true for moderate or severe limitations (20.8% vs 4.5%; P\u2009=\u2009.035). Likewise, functional independence for personal care, mobility, and self-care activities was poorer in patients with ICUAW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients surviving an ICU stay due to COVID-19, decreased functional independence persists even 6\u00a0months after discharge, and patients with ICUAW have worse outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Patients who survive ICU stays due to COVID-19 continue to have greater functional dependence even 6\u00a0months after ICU discharge.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzad117","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T11:30:50Z","timestamp":1693654250000},"source":"Crossref","is-referenced-by-count":13,"title":["Post\u2013COVID-19 Intensive Care Unit-Acquired Weakness Compromises Long-Term Functional Status"],"prefix":"10.1093","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-6328","authenticated-orcid":false,"given":"D\u00e9bora","family":"Schmidt","sequence":"first","affiliation":[{"name":"Physical Therapy Service, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) , Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"},{"name":"Graduate Program in Human Movement Science (PPGCMH), Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Glauce","family":"Margarites","sequence":"additional","affiliation":[{"name":"Physical Therapy Service, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) , Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Pinto Kr\u00e1s Borges","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Physical Therapy Service, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) , Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Moliterni","family":"Paesi","sequence":"additional","affiliation":[{"name":"Physical Therapy Service, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) , Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Friedman","sequence":"additional","affiliation":[{"name":"Intensive Care Services , HCPA, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciele","family":"Sbruzzi","sequence":"additional","affiliation":[{"name":"Physical Therapy Service, Hospital de Cl\u00ednicas de Porto Alegre (HCPA) , Santa Cec\u00edlia, Porto Alegre, Rio Grande do Sul , Brazil"},{"name":"Graduate Program in Human Movement Science (PPGCMH), Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"2023122812031741100_ref1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1186\/s12879-021-06536-3","article-title":"Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients","volume":"21","author":"Dessie","year":"2021","journal-title":"BMC Infect Dis"},{"key":"2023122812031741100_ref2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort 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