{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:34:08Z","timestamp":1791894848141,"version":"4.3.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Consortium of Multiple Sclerosis Centers Pilot Award Program"},{"name":"National Center Medical Rehabilitation Research"},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute Neurological Disorders and Stroke"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12 HD055931"],"award-info":[{"award-number":["K12 HD055931"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["UL1-TR001082"],"award-info":[{"award-number":["UL1-TR001082"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["TL1-TR002535"],"award-info":[{"award-number":["TL1-TR002535"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to determine the feasibility of low-load resistance training with blood flow restriction (BFR) for people with advanced disability due to multiple sclerosis (MS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective cohort study, 14 participants with MS (Expanded Disability Status Scale [EDSS] score\u2009=\u20096.0 to 7.0; mean age\u2009=\u200955.4 [SD\u2009=\u20096.2] years; 71% women) were asked to perform 3 lower extremity resistance exercises (leg press, calf press, and hip abduction) bilaterally twice weekly for 8\u00a0weeks using BFR. Feasibility criteria were as follows: enrollment of 20 participants, \u226580% retention and adherence, \u226590% satisfaction, and no serious adverse events related to the intervention. Other outcomes included knee extensor, ankle plantar flexor, and hip abductor muscle strength, 30-Second Sit-to-Stand Test, Berg Balance Scale, Timed 25-Foot Walk Test, 12-Item MS Walking Scale, Modified Fatigue Impact Scale, Patient-Specific Functional Scale, and daily step count.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixteen participants consented, and 14 completed the intervention, with 93% adherence overall. All participants were satisfied with the intervention. A minor hip muscle strain was the only intervention-related adverse event. There were muscle strength improvements on the more-involved (16%\u201328%) and less-involved (12%\u201319%) sides. There were also changes in the 30-Second Sit-to-Stand Test (1.9 repetitions; 95% CI\u2009=\u20091.0 to 2.8), Berg Balance Scale (5.3 points; 95% CI\u2009=\u20093.2 to 7.4), Timed 25-Foot Walk Test (\u22123.3\u00a0seconds; 95% CI\u2009=\u2009\u22127.9 to 1.3), Modified Fatigue Impact Scale (\u22128.8 points; 95% CI\u2009=\u2009\u221216.5 to \u22121.1), 12-Item MS Walking Scale (\u22123.6 points; 95% CI\u2009=\u2009\u221211.5 to 4.4), Patient-Specific Functional Scale (2.9 points; 95% CI\u2009=\u20091.9 to 3.8), and daily step count (333 steps; 95% CI\u2009=\u2009\u2212191 to 857).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Low-load resistance training using BFR in people with MS and EDSS scores of 6.0 to 7.0 appears feasible, and subsequent investigation into its efficacy is warranted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Although efficacy data are needed, combining BFR with low-load resistance training may be a viable alternative for people who have MS and who do not tolerate conventional moderate- to high-intensity training because of more severe symptoms, such as fatigue and weakness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay Summary<\/jats:title>\n                  <jats:p>Low-load strength training with BFR was feasible in people who have advanced disability due to MS. Using BFR may provide an alternative for people with MS who do not tolerate higher intensity training due to more severe symptoms, such as fatigue and weakness.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzad135","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T16:58:20Z","timestamp":1696957100000},"source":"Crossref","is-referenced-by-count":17,"title":["Feasibility of Low-Load Resistance Training Using Blood Flow Restriction for People With Advanced Multiple Sclerosis: A Prospective Cohort Study"],"prefix":"10.1093","volume":"104","author":[{"given":"Mark M","family":"Ma\u00f1ago","sequence":"first","affiliation":[{"name":"Physical Therapy Program , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"University of Colorado Anschutz Medical Campus , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"Department of Neurology , School of Medicine, , Aurora, Colorado , USA"},{"name":"University of Colorado , School of Medicine, , Aurora, Colorado , USA"},{"name":"VA Eastern Colorado Healthcare System , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan T","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Arcadia University , Glenside, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Neurology , School of Medicine, , Aurora, Colorado , USA"},{"name":"University of Colorado , School of Medicine, , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R","family":"Hager","sequence":"additional","affiliation":[{"name":"Physical Therapy Program , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"University of Colorado Anschutz Medical Campus , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"VA Eastern Colorado Healthcare System , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny G","family":"Owens","sequence":"additional","affiliation":[{"name":"Owens Recovery Science , San Antonio, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bade","sequence":"additional","affiliation":[{"name":"Physical Therapy Program , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"University of Colorado Anschutz Medical Campus , Department of Physical Medicine and Rehabilitation, , Aurora, Colorado , USA"},{"name":"VA Eastern Colorado Healthcare System , Aurora, Colorado , 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