{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:52:31Z","timestamp":1781286751825,"version":"3.54.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aims of the current study were to investigate the presence of widespread pressure hyperalgesia, the presence of structural changes in the wrist extensor tendon and muscle, and their association in people with lateral epicondylalgia (LE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-seven patients with LE (43% women; mean age\u2009=\u200945.5 [SD\u2009=\u20099.5] years) and 37 controls matched for age and sex and free of pain participated in this study. Pressure pain thresholds (PPTs) were assessed bilaterally over the symptomatic area (elbow), 2 segment-related areas (C5\u2013C6 joint, second intermetacarpal space), and 1 remote area (tibialis anterior) in a blinded design. Ultrasound measurements (eg, cross-sectional area, thickness, and width) of the common wrist extensor tendon and extensor carpi radialis brevis muscle as well as the thickness of the supinator muscle were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with LE exhibited lower PPTs bilaterally at all points and lower PPTs at the lateral epicondyle and second intermetacarpal space on the symptomatic side as compared to the nonsymptomatic side (\u03b72 from 0.123\u20130.369; large effects). Patients exhibited higher cross-sectional area and width of the common wrist extensor tendon (\u03b72 from 0.268\u20130.311; large effects) than controls bilaterally, whereas tendon thickness was also higher (\u03b72\u2009=\u20090.039; small effects) on the painful side than on the nonpainful side.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study reported bilateral widespread pressure pain hyperalgesia and morphological changes in the tendon, but not the muscle, in LE. Pressure pain sensitivity and morphological changes were not associated in individuals with LE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Management of LE should consider altered nociceptive pain processing and structural tendon changes as 2 different phenomena in patients with LE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzae075","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T23:29:00Z","timestamp":1717543740000},"source":"Crossref","is-referenced-by-count":2,"title":["Widespread Pressure Pain Hyperalgesia Is Not Associated With Morphological Changes of the Wrist Extensor Tendon in Unilateral Lateral Epicondylalgia: A Case\u2013Control Study"],"prefix":"10.1093","volume":"104","author":[{"given":"Ignacio","family":"Cancela-Cilleruelo","sequence":"first","affiliation":[{"name":"Escuela Internacional de Doctorado, Universidad Rey Juan Carlos , Alcorc\u00f3n, Spain"},{"name":"Universidad Rey Juan Carlos Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, , Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rodr\u00edguez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Universidad Rey Juan Carlos Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, , Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Universidad Rey Juan Carlos Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, , Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Cleland","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Doctor of 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