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The benefits of prestroke physical activity on these limitations remain unclear. To clarify this relationship, the effect of physical activity on the long-term evolution of functional limitations in a cohort of people with stroke compared to a cohort of matched adults without stroke was examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Longitudinal data from 2143 people with stroke and 10,717 adults without stroke aged 50\u00a0years and older were drawn from a prospective cohort study based on the Survey of Health, Ageing and Retirement in Europe (2004\u20132022; eight data collection waves). Physical activity was assessed in the prestroke wave. Functional limitations were assessed in the poststroke waves. Each person with stroke was matched with five adults without stroke who had similar propensity scores computed on the basis of key covariates, including baseline age, sex, body mass index, limitations in ADLs and IADLs, chronic conditions, and country of residence, before any of the participants from either cohort had experienced a stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Results showed an interaction between stroke status and physical activity on ADL limitations (b\u2009=\u2009\u22120.076; 95% CI\u2009=\u2009\u22120.142 to \u22120.011), with the beneficial effect of physical activity being stronger in people with stroke (b\u2009=\u2009\u22120.345; 95% CI\u2009=\u2009\u22120.438 to \u22120.252) than in adults without stroke (b\u2009=\u2009\u22120.269; 95% CI\u2009=\u2009\u22120.269 to \u22120.241).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The beneficial effect of prestroke physical activity on ADL limitations after stroke is stronger than its effect in matched adults without stroke followed for a similar number of years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:p>Physical activity, an intervention within the physical therapist\u2019s scope of practice, is effective in reducing the risk of functional dependence after stroke. Moreover, prestroke levels of physical activity can inform the prognosis of functional dependence in people with stroke.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzae094","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T12:11:46Z","timestamp":1721131906000},"source":"Crossref","is-referenced-by-count":8,"title":["Prestroke Physical Activity Matters for Functional Limitations: A Longitudinal Case\u2013Control Study of 12,860 Participants"],"prefix":"10.1093","volume":"104","author":[{"given":"Zachary M","family":"van Allen","sequence":"first","affiliation":[{"name":"School of Rehabilitation Sciences , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]},{"name":"University of Ottawa , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]},{"name":"Perley Health Centre of Excellence in Frailty-Informed Care , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Orsholits","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]},{"name":"University of Ottawa , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu P","family":"Boisgontier","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]},{"name":"University of Ottawa , Faculty of Health Sciences, , Ottawa, Ontario,","place":["Canada"]},{"name":"Perley Health Centre of Excellence in Frailty-Informed Care , Ottawa, 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