{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:04:47Z","timestamp":1793210687046,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The purpose of this study was to examine the dose-response relationship between aerobic exercise programs and changes in pain intensity and health status in patients with fibromyalgia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>Data sources for this study were PubMed, PEDro, Google Scholar, and EBSCO from inception until February 9, 2024.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Selection<\/jats:title>\n                  <jats:p>Randomized controlled trials (RCTs) of aerobic exercise in patients with a clinical diagnosis of fibromyalgia were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>Outcome measures were pain intensity (Visual Analog Scale) and health status (Fibromyalgia Impact Questionnaire (FIQ)). The dose-response relationship was evaluated using a restricted cubic spline model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Synthesis<\/jats:title>\n                  <jats:p>Twenty-three RCTs were included. The meta-analysis showed a significant improvement in pain intensity and functional status. A minimum dose of 50\u00a0min per week standardized mean difference (SMD\u2009=\u2009\u22120.67; 95% CI\u2009=\u2009\u22120.70 to \u22120.65) and a total duration of 600\u00a0min (SMD\u2009=\u2009\u22120.65; 95% CI\u2009=\u2009\u22120.69 to \u22120.62) were estimated to effectively reduce pain intensity. The maximum effect was achieved with 90\u00a0min per week (SMD\u2009=\u2009\u22121.14; 95% CI\u2009=\u2009\u22121.19 to \u22121.09) and 1200\u00a0min total duration (SMD\u2009=\u2009\u22121.08; 95%CI\u2009=\u2009\u22121.13 to \u22121.02). Additionally, a minimum dose of 65\u00a0min per week (SMD\u2009=\u2009\u22120.62; 95% CI\u2009=\u2009\u22120.6 to \u22120.69) and a total duration of 950\u00a0min (SMD\u2009=\u2009\u22120.61; 95% CI\u2009=\u2009\u22120.60 to \u22120.67) were estimated to effectively reduce the FIQ score. While the maximum effect was obtained with 150\u00a0min per week (SMD\u2009=\u2009\u22121.77; 95% CI\u2009=\u2009\u22121.89 to \u22121.65) and 3000\u00a0min of total duration (SMD\u2009=\u2009\u22121.43; 95% CI\u2009=\u2009\u22121.54 to \u22121.31).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings may be useful in optimizing the minimal dose of aerobic exercise to achieve health improvements in people with fibromyalgia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzaf057","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:37:34Z","timestamp":1745505454000},"source":"Crossref","is-referenced-by-count":10,"title":["Optimal Dose of Aerobic Exercise Programs to Reduce Pain Intensity and Improve Health Status in Patients With Fibromyalgia: A Dose-Response Meta-Analysis"],"prefix":"10.1093","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-9338","authenticated-orcid":false,"given":"Rodrigo","family":"N\u00fa\u00f1ez-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine, University of Chile , Santiago ,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-4243","authenticated-orcid":false,"given":"Luis","family":"Suso-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Almonacid-Lleida","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia 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