{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:10:17Z","timestamp":1771942217033,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["CER-1310-06994"],"award-info":[{"award-number":["CER-1310-06994"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health"},{"name":"NIH HEAL Initiative","award":["U19AR076725-01"],"award-info":[{"award-number":["U19AR076725-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Total knee replacement (TKR) is common for advanced cartilage degeneration. Often, functional limitations persist, and late-stage exercise (2\u20134\u00a0months after TKR) may improve recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to identify predictors of late-stage functional recovery after TKR and their variations by exercise program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This study was a secondary analysis of a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The settings were 1 physical therapy clinic and 4 community centers in Allegheny County, Pennsylvania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study included 199 individuals (mean age\u2009=\u200970\u00a0years; body mass index\u2009=\u200931\u00a0kg\/m2; 60% women).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Interventions were physical therapy exercises, community-based exercises, and usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome and Measures<\/jats:title>\n                    <jats:p>The main outcome was functional recovery at 6\u00a0months after intervention. Functional recovery was defined as \u226550% improvement on the Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale, at least somewhat better on the Global Rating of Change, and\u2009\u2265\u200920% improvement on \u22652 performance-based tests. Predictors were identified using logistic regression. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the entire cohort, 33% of participants achieved functional recovery, including 42% in the physical therapy group and 38% in the community group. Overall, better baseline health (odds ratio [OR]\u2009=\u20092.70 [95% CI\u2009=\u20091.34\u20135.47]), discharge to home (OR\u2009=\u20096.24 [95% CI\u2009=\u20091.94\u201320.09]), and higher Western Ontario and McMaster Universities Osteoarthritis Index pain subscale scores (OR\u2009=\u20091.22 [95% CI\u2009=\u20091.07\u20131.40]) predicted functional recovery. In the physical therapy group (n\u2009=\u200983), positive predictors were better health (OR\u2009=\u20094.40 [95% CI\u2009=\u20091.20\u201316.06]), discharge to home (OR\u2009=\u200911.67 [95% CI\u2009=\u20092.01\u201367.76]), regular use of nonsteroidal anti-inflammatory drugs (OR\u2009=\u20093.76 [95% CI\u2009=\u20091.11\u201312.78]), and as-needed use of analgesics (OR\u2009=\u200910.53 [95% CI\u2009=\u20091.75\u201363.48]). Negative predictors, associated with a lower likelihood of recovery, were regular use of salicylates (OR\u2009=\u20090.22 [95% CI\u2009=\u20090.07\u20130.74]) and greater use of pain-coping strategies (OR\u2009=\u20090.51 [95% CI\u2009=\u20090.29\u20130.89]). No predictors were identified in the community group (n\u2009=\u200976).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Better baseline health, discharge to home after TKR, and higher pain levels predicted functional recovery. Physical therapy provided additional benefits for a subset of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance<\/jats:title>\n                    <jats:p>This evidence helps clinicians set realistic functional recovery expectations and strategies to facilitate function late after TKR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ptj\/pzag006","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:40:50Z","timestamp":1768999250000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Functional Recovery in Individuals Exposed to Late-Stage Exercise Programs After Total Knee Replacement: A Secondary Analysis of a Randomized Controlled Trial"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-1394","authenticated-orcid":false,"given":"Cristiane R","family":"Carlesso","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA ,","place":["United States"]},{"name":"Department of Physical Therapy & Athletic Training, University of Utah , Salt Lake City, UT ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-0237","authenticated-orcid":false,"given":"Clair","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-0124","authenticated-orcid":false,"given":"Charity G","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-8844","authenticated-orcid":false,"given":"Allyn M","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1716-3151","authenticated-orcid":false,"given":"Sara R","family":"Piva","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"issue":"2","key":"2026022408365387900_ref1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.arth.2007.11.015","article-title":"Primary and revision arthroplasty surgery caseloads in the United States from 1990 to 2004","volume":"24","author":"Kurtz","year":"2009","journal-title":"J Arthroplast"},{"issue":"7","key":"2026022408365387900_ref2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.jmpt.2019.05.003","article-title":"Application of ultrasonography in the assessment of abdominal and lumbar trunk muscle activity in participants with and without low back pain: a systematic review","volume":"42","author":"ShahAli","year":"2019","journal-title":"J Manip Physiol Ther"},{"issue":"1","key":"2026022408365387900_ref3","doi-asserted-by":"publisher","first-page":"e000435","DOI":"10.1136\/bmjopen-2011-000435","article-title":"What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? 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