{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:58:24Z","timestamp":1773295104941,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA139118"],"award-info":[{"award-number":["R01CA139118"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA08393"],"award-info":[{"award-number":["P50CA08393"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Adele McKinnon Research Fund for Breast Cancer-Related Lymphedema"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is little research on hand edema in the population at risk for breast cancer\u2013related lymphedema (BCRL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Study aims included reporting potential importance of hand edema (HE) as a risk factor for progression of edema in patients treated for breast cancer at risk for BCRL, reporting risk factors for BCRL, and reporting treatment of HE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design\/Methods<\/jats:title>\n                  <jats:p>This was a retrospective analysis of 9 patients treated for breast cancer in Massachusetts General Hospital's lymphedema screening program who presented with isolated HE. Limb volumes via perometry, BCRL risk factors, and HE treatment are reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Edema was mostly isolated to the hand. Three patients had arm edema &amp;gt;5% on perometry; and 2 of these had edema outside the hand on clinical examination. Patients were at high risk of BCRL with an average of 2.9\/5 known risk factors. Arm edema progressed to &amp;gt;10% in 2 high-risk patients. Treatment resulted in an average hand volume reduction of 10.2% via perometry and improvement upon clinical examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>The small sample size and lack of validated measures of subjective data were limitations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this cohort, patients with HE carried significant risk factors for BCRL. Two out of 9 (22%), both carrying \u22654\/5 risk factors, progressed to edema &amp;gt;10%. Isolated HE may be a prognostic factor for edema progression in patients treated for breast cancer at risk for BCRL. Further research is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzy007","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:17:31Z","timestamp":1516234651000},"page":"510-517","source":"Crossref","is-referenced-by-count":7,"title":["Hand Edema in Patients at Risk of Breast Cancer\u2013Related Lymphedema: Health Professionals Should Take Notice"],"prefix":"10.1093","volume":"98","author":[{"given":"Cheryl L","family":"Brunelle","sequence":"first","affiliation":[{"name":"Department of Physical and Occupational Therapy, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meyha N","family":"Swaroop","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa N","family":"Skolny","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S","family":"Asdourian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda E","family":"Sayegh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alphonse G","family":"Taghian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 (USA)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"issue":"6","key":"2023011806111744500_bib1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1470-2045(13)70076-7","article-title":"Incidence of unilateral arm lymphoedema after breast cancer: A systematic review and meta-analysis","volume":"14","author":"DiSipio","year":"2013","journal-title":"Lancet Oncol"},{"key":"2023011806111744500_bib2","volume-title":"American Cancer Society website","author":"Breast cancer facts and figures: 2017\u20132018"},{"issue":"5","key":"2023011806111744500_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1188\/14.ONF.473-483","article-title":"Factors associated with fear of lymphedema after treatment for breast cancer","volume":"41","author":"Jammallo","year":"2014","journal-title":"Oncol Nurs Forum"},{"key":"2023011806111744500_bib4","first-page":"170","article-title":"The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the International Society of Lymphology","volume":"49","author":"International Society of Lymphology","year":"2016","journal-title":"Lymphology"},{"issue":"1","key":"2023011806111744500_bib5","first-page":"1","article-title":"Prospective evaluation of a prevention protocol for lymphedema following surgery for breast cancer","volume":"42","author":"Boccardo","year":"2009","journal-title":"Lymphology"},{"issue":"1","key":"2023011806111744500_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2522\/ptj.20100167","article-title":"Breast cancer-related lymphedema: Comparing direct costs of a prospective surveillance model and a traditional model of care","volume":"92","author":"Stout","year":"2012","journal-title":"Phys Ther"},{"issue":"2","key":"2023011806111744500_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/jpm5020153","article-title":"Establishing and sustaining a prospective screening program for breast cancer-related lymphedema at the Massachusetts General Hospital: Lessons learned","volume":"5","author":"Brunelle","year":"2015","journal-title":"J Pers Med"},{"issue":"3","key":"2023011806111744500_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3390\/jpm5030311","article-title":"Prospective lymphedema surveillance in a clinic setting","volume":"5","author":"Chance-Hetzler","year":"2015","journal-title":"J Pers Med"},{"key":"2023011806111744500_bib9","article-title":"Screening and measurement for early detection of breast cancer-related lymphedema","volume-title":"Position Statement of the National Lymphedema Network","author":"NLN Medical Advisory Committee","year":"2011"},{"issue":"10","key":"2023011806111744500_bib10","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1245\/s10434-017-5982-4","article-title":"Considerations for clinicians in the diagnosis, prevention, and treatment of breast cancer-related lymphedema: Recommendations from a multidisciplinary expert ASBrS panel. 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