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These conditions are common and often unrecognized, and patients are likely to present in physical therapy for musculoskeletal injuries, pain, or coordination deficits. Although physical therapy is considered central to managing these conditions, many patients report pain and iatrogenic injuries due to inappropriate interventions. The diagnostic classification for these conditions was revised in 2017 to supersede previous diagnostic categories of Joint Hypermobility Syndrome and Ehlers-Danlos Syndrome\u2014hypermobility type\/type III. It is now known that these conditions affect multiple body systems and not just joints and that patients require a holistic approach. This Perspective article will describe the 2017 diagnostic classification system, clinical presentation, examination, evaluation, and management of patients with HSD\/hEDS. Both adult and pediatric cases are presented to illustrate the patient management concepts discussed. This knowledge can lead to more effective management of this patient population.<\/jats:p>","DOI":"10.1093\/ptj\/pzz078","type":"journal-article","created":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T03:09:23Z","timestamp":1559444963000},"page":"1189-1200","source":"Crossref","is-referenced-by-count":37,"title":["Recognizing and Effectively Managing Hypermobility-Related Conditions"],"prefix":"10.1093","volume":"99","author":[{"given":"Leslie N","family":"Russek","sequence":"first","affiliation":[{"name":"Physical Therapy Department, Clarkson University, Potsdam, NY 13699 (USA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Stott","sequence":"additional","affiliation":[{"name":"Elevation Wellness, Golden, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"2023011903530976900_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ajmg.c.31539","article-title":"A framework for the classification of joint hypermobility and related conditions","volume":"175","author":"Castori","year":"2017","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2023011903530976900_bib2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/MOP.0000000000000541","article-title":"Contemporary approach to joint hypermobility and related disorders","volume":"29","author":"Castori","year":"2017","journal-title":"Curr Opin Pediatr"},{"key":"2023011903530976900_bib3","doi-asserted-by":"crossref","first-page":"e010364","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"key":"2023011903530976900_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.31538","article-title":"Hypermobile Ehlers-Danlos syndrome (a.k.a. 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