{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:27:49Z","timestamp":1749796069311},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Agenesis of the corpus callosum (ACC) is a rare congenital brain defect that produces a wide variety of cognitive and motor impairments. Literature regarding the response of pediatric populations with ACC to physical rehabilitation is scarce. Treadmill-based gait training (TT) has been shown to improve walking ability in some pediatric populations but has not been investigated in children with ACC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The purpose of this study was to investigate the effect of a novel treadmill intervention paradigm on the gait parameters of a child with ACC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A single-participant design with 2 phases was used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The settings were the participant\u2019s home and the laboratory. The participant was a 13-year-old girl who had ACC and cortical visual impairment and who ambulated independently using a reverse walker for household and short community distances. A home-based TT intervention (2 phases of 3\u00a0months of training over 6\u00a0months) was implemented, and a laboratory-based gait analysis was conducted at 4 time points: baseline, after each of the 2 training phases, and 3\u00a0months after the cessation of training. The intervention consisted of weekly bouts of TT. Phase I incorporated forward, backward, and incline walking for 15\u00a0minutes each; in phase II, this protocol was continued, but short-burst interval training for 10\u00a0minutes was added. Data collected at each laboratory visit included spatiotemporal parameters and kinematics (joint angles) during overground and treadmill walking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After both phases of training, increased step length, decreased step width, and foot progression angle and decreased variability of most spatiotemporal parameters were observed for the participant. Further, after phase II, increased peak extension at the hip, knee, and ankle, decreased crouched gait, and improved minimum foot clearance during overground walking were observed. Most gait improvements were retained for 3\u00a0months after the cessation of the intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>The small sample size of this study and wide variety of presentations within individuals with ACC limit the generalizability of our findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>TT may be a safe and effective treatment paradigm for children with ACC. Future research should investigate the effect of intervention dosage on gait improvements and generalization in individuals with ACC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ptj\/pzz144","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:24:18Z","timestamp":1569957858000},"page":"157-167","source":"Crossref","is-referenced-by-count":3,"title":["Improvement in Overground Walking After Treadmill-Based Gait Training in a Child With Agenesis of the Corpus Callosum"],"prefix":"10.1093","volume":"100","author":[{"given":"Gena","family":"Henderson","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health , Georgia State University, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Beerse","sequence":"additional","affiliation":[{"name":"Department of Health and Sports Science , University of Dayton, Dayton, 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Neurol."},{"key":"2023011704463181000_ref4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/87565641.2012.721421","article-title":"Neuropsychological profile of agenesis of the corpus callosum: a systematic review","volume":"38","author":"Siffredi","year":"2013","journal-title":"Dev Neuropsychol."},{"key":"2023011704463181000_ref5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2214.2009.00942.x","article-title":"Physical, motor, sensory and developmental features associated with agenesis of the corpus callosum","volume":"35","author":"Moes","year":"2009","journal-title":"Child Care Health Dev."},{"key":"2023011704463181000_ref6","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3109\/09638288.2013.833299","article-title":"Agenesis of the corpus callosum: classifying functional manifestations with the ICF-CY","volume":"36","author":"Kovac","year":"2014","journal-title":"Disabil Rehabil."},{"key":"2023011704463181000_ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/arclin\/3.2.189","article-title":"The clinical significance of congenital agenesis of the corpus callosum","volume":"3","author":"Bigler","year":"1988","journal-title":"Arch Clin Neuropsychol."},{"key":"2023011704463181000_ref8","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1037\/a0016868","article-title":"Bimanual motor coordination in agenesis of the corpus callosum","volume":"123","author":"Mueller","year":"2009","journal-title":"Behav Neurosci."},{"key":"2023011704463181000_ref9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0166-4328(94)90135-X","article-title":"Cognitive and sensori-motor functioning in the absence of the corpus callosum: neuropsychological studies in callosal agenesis and callosotomized patients","volume":"64","author":"Sauerwein","year":"1994","journal-title":"Behav Brain Res."},{"key":"2023011704463181000_ref10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/PEP.0b013e31811ec7af","article-title":"Outcomes of infants with idiopathic hypotonia","volume":"19","author":"Strubhar","year":"2007","journal-title":"Pediatr Phys Ther."},{"key":"2023011704463181000_ref11","doi-asserted-by":"crossref","first-page":"e950","DOI":"10.1542\/peds.2011-3712","article-title":"The relationship between motor coordination and intelligence across the IQ range","volume":"130","author":"Smits-Engelsman","year":"2012","journal-title":"Pediatrics."},{"key":"2023011704463181000_ref12","first-page":"85","article-title":"Long term outcomes of physical therapy patients with agenesis of the corpus callosum","volume":"5","author":"Akbal","year":"2013","journal-title":"Ortadogu Med J."},{"key":"2023011704463181000_ref13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1590\/0103-0582201432317","article-title":"Pediatric neurofunctional intervention in agenesis of the corpus callosum: a case report","volume":"32","author":"Pacheco","year":"2014","journal-title":"Rev Paul Pediatr."},{"key":"2023011704463181000_ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.gaitpost.2007.03.014","article-title":"Long-term effect of different treadmill interventions on gait development in new walkers with down syndrome","volume":"27","author":"Angulo-Barroso","year":"2008","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/NPT.0b013e31819800e2","article-title":"A systematic review of the effectiveness of treadmill training and body weight support in pediatric rehabilitation","volume":"33","author":"Damiano","year":"2009","journal-title":"J Neurol Phys Ther."},{"key":"2023011704463181000_ref16","doi-asserted-by":"crossref","DOI":"10.1542\/peds.108.5.e84","article-title":"Treadmill training of infants with down syndrome: evidence-based developmental outcomes","volume":"108","author":"Ulrich","year":"2001","journal-title":"Pediatrics."},{"key":"2023011704463181000_ref17","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1469-8749.2007.00839.x","article-title":"Exploring effects of different treadmill interventions on walking onset and gait patterns in infants with down syndrome","volume":"49","author":"Wu","year":"2007","journal-title":"Dev Med Child Neurol."},{"key":"2023011704463181000_ref18","article-title":"Treadmill interventions in children under six years of age at risk of neuromotor delay","volume":"7","author":"Valentin-Gudiol","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2023011704463181000_ref19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/PHM.0b013e3182643eba","article-title":"The effect of treadmill training on gross motor function and walking speed in ambulatory adolescents with cerebral palsy: a randomized controlled trial","volume":"91","author":"Chrysagis","year":"2012","journal-title":"Am J Phys Med Rehabil."},{"key":"2023011704463181000_ref20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/dmcn.12660","article-title":"Exercise interventions improve postural control in children with cerebral palsy: a systematic review","volume":"57","author":"Dewar","year":"2015","journal-title":"Dev Med Child Neurol."},{"key":"2023011704463181000_ref21","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2522\/ptj.20150401","article-title":"Effectiveness of rehabilitation interventions to improve gait speed in children with cerebral palsy: systematic review and meta-analysis","volume":"96","author":"Moreau","year":"2016","journal-title":"Phys Ther."},{"key":"2023011704463181000_ref22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/0269215514547654","article-title":"Effect of backward walking training on postural balance in children with hemiparetic cerebral palsy: a randomized controlled study","volume":"29","author":"El-Basatiny","year":"2015","journal-title":"Clin Rehabil."},{"key":"2023011704463181000_ref23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/MRR.0b013e32835dd620","article-title":"Backward walking treadmill therapy can improve walking ability in children with spastic cerebral palsy: a pilot study","volume":"36","author":"Kim","year":"2013","journal-title":"Int J Rehabil Res."},{"key":"2023011704463181000_ref24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gaitpost.2011.08.025","article-title":"The effects of grade and speed on leg muscle activations during walking","volume":"35","author":"Franz","year":"2012","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/17518423.2018.1462270","article-title":"Short-burst interval treadmill training walking capacity and performance in cerebral palsy: a pilot study","volume":"22","author":"Bjornson","year":"2019","journal-title":"Dev Neurorehabil."},{"key":"2023011704463181000_ref26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.gaitpost.2011.08.027","article-title":"Rapid force generation is impaired in cerebral palsy and is related to decreased muscle size and functional mobility","volume":"35","author":"Moreau","year":"2012","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref27","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.clinph.2015.02.005","article-title":"Impaired gait function in adults with cerebral palsy is associated with reduced rapid force generation and increased passive stiffness","volume":"126","author":"Geertsen","year":"2015","journal-title":"Clin Neurophysiol."},{"key":"2023011704463181000_ref28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2519\/jospt.1995.22.3.95","article-title":"Backward walking at three levels of treadmill inclination: an electromyographic and kinematic analysis","volume":"22","author":"Cipriani","year":"1995","journal-title":"J Orthop Sports Phys Ther."},{"key":"2023011704463181000_ref29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1123\/japa.2013-0236","article-title":"Walking speed: the functional vital sign","volume":"23","author":"Middleton","year":"2015","journal-title":"J Aging Phys Act."},{"key":"2023011704463181000_ref30","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.gaitpost.2007.07.007","article-title":"Two simple methods for determining gait events during treadmill and overground walking using kinematic data","volume":"27","author":"Zeni","year":"2008","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.gaitpost.2018.11.032","article-title":"Variability of spatiotemporal gait parameters in children with and without down syndrome during treadmill walking","volume":"68","author":"Beerse","year":"2019","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref32","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s10439-010-9952-2","article-title":"How crouch gait can dynamically induce stiff-knee gait","volume":"38","author":"van der","year":"2010","journal-title":"Ann Biomed Eng."},{"key":"2023011704463181000_ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gaitpost.2017.12.017","article-title":"Fatigue, quality of life, and walking ability in adults with cerebral palsy","volume":"61","author":"Lundh","year":"2018","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gaitpost.2009.05.010","article-title":"Crouch gait patterns defined using k-means cluster analysis are related to underlying clinical pathology","volume":"30","author":"Rozumalski","year":"2009","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref35","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1016\/j.jbiomech.2016.06.007","article-title":"Characterisation of foot clearance during gait in people with early Parkinson's disease: deficits associated with a dual task","volume":"49","author":"Alcock","year":"2016","journal-title":"J Biomech."},{"key":"2023011704463181000_ref36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/ptj\/72.1.45","article-title":"Foot trajectory in human gait: a precise and multifactorial motor control task","volume":"72","author":"Winter","year":"1992","journal-title":"Phys Ther."},{"key":"2023011704463181000_ref37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.gaitpost.2011.09.105","article-title":"Reliability and minimal detectible change values for gait kinematics and kinetics in healthy adults","volume":"35","author":"Wilken","year":"2012","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.gaitpost.2018.09.010","article-title":"Transitioning from the level surface to stairs in children with and without down syndrome: motor strategy and anticipatory locomotor adjustments","volume":"66","author":"Liang","year":"2018","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref39","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jbiomech.2008.03.015","article-title":"The effect of walking speed on the gait of typically developing children","volume":"41","author":"Schwartz","year":"2008","journal-title":"J Biomech."},{"key":"2023011704463181000_ref40","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1469-8749.2008.03150.x","article-title":"Outcome tools used for ambulatory children with cerebral palsy: responsiveness and minimum clinically important differences","volume":"50","author":"Oeffinger","year":"2008","journal-title":"Dev Medicine Child Neurol."},{"key":"2023011704463181000_ref41","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1016\/j.jbiomech.2012.07.028","article-title":"How much muscle strength is required to walk in a crouch gait?","volume":"45","author":"Steele","year":"2012","journal-title":"J Biomech."},{"key":"2023011704463181000_ref42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.gaitpost.2006.03.008","article-title":"Minimum foot clearance during walking: strategies for the minimisation of trip-related falls","volume":"25","author":"Begg","year":"2007","journal-title":"Gait Posture."},{"key":"2023011704463181000_ref43","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.2522\/ptj.2010090","article-title":"Perspective on variability in the development of human action","volume":"90","author":"Fetters","year":"2010","journal-title":"Phys Ther."},{"key":"2023011704463181000_ref44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/NPT.0b013e3182386de1","article-title":"Patterns of gait variability across the lifespan in persons with and without down syndrome","volume":"35","author":"Smith","year":"2011","journal-title":"J Neurol Phys Ther."},{"key":"2023011704463181000_ref45","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.2307\/1130427","article-title":"Treadmill-elicited stepping in seven-month-old infants","volume":"57","author":"Thelen","year":"1986","journal-title":"Child Dev."}],"container-title":["Physical 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