{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:39:58Z","timestamp":1740152398362,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment refusal, defined as active refusal of a patient to receive treatment despite physician recommendations, has not been extensively evaluated before in hepatitis C virus in the era of direct acting antivirals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the reasons for refusal to receive hepatitis C virus treatment in Egypt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>an observational study conducted between July 2018 and November 2019 in Egypt. Enrollment was done to all patients who refused to get hepatitis C virus treatment during the national screening and treatment campaign. Reasons for their refusal were identified using a questionnaire as an instrument for data collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 220\u00a0280 Egyptian hepatitis C virus patients who did not show up to start treatment and were contacted to get therapy, only 84 patients (0.038%) refused to receive treatment. The main reason for their refusal was having concerns about treatment (82.14%) and their main concern was the fear of adverse events (85.5%). Other causes of refusal were non-satisfactory experience at treatment centers (13.09%) and patients preferred to receive complementary and alternative medicines (4.7%). Most patients (65.4%) trusted the efficacy of directly acting antivirals for hepatitis C. None of the study participants was found to suffer from any psychiatric morbidity and the average score of the GHQ-12 was 10.7155.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proper health education and awareness regarding hepatitis C virus treatment safety and efficacy is needed to increase treatment acceptance rates.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pubmed\/fdab363","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T11:35:06Z","timestamp":1631878506000},"page":"214-217","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of factors affecting patients\u2019 refusal of HCV treatment in a cohort of Egyptian patients"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-3525","authenticated-orcid":false,"given":"Mohamed B","family":"Hashem","sequence":"first","affiliation":[{"name":"Endemic medicine department , Faculty of Medicine, Cairo University, Cairo 11652, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedy A","family":"Badary","sequence":"additional","affiliation":[{"name":"Endemic medicine department , Faculty of Medicine, Cairo University, Cairo 11652, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha A","family":"Mahfouz","sequence":"additional","affiliation":[{"name":"Department of psychiatry , Faculty of Medicine, Cairo University, Cairo 11652, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaden","family":"Adel","sequence":"additional","affiliation":[{"name":"Department of psychiatry , Faculty of Medicine, Cairo University, Cairo 11652, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Alboraie","sequence":"additional","affiliation":[{"name":"Department of internal medicine , Al-Azhar University, Cairo 11651, 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