{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:57:57Z","timestamp":1762642677243},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to assess the specific associations between stroke and all-cause and cause-specific mortality among Korean adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data extracted from the Korean National Health Insurance claims database from 2002 to 2013, including information on individuals with or without stroke aged 20\u00a0years and older. Patients with intracerebral hemorrhage, ischemic stroke or unspecified stroke were classified as stroke patients, while a reference population matched in terms of sex and age were also selected. The outcomes were all-cause mortality, natural causes of death (i.e. all natural causes, death by stroke and death by other diseases) and suicide. Survival analysis was performed using the Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 73\u00a0150 eligible participants\u2014including 14\u00a0630 stroke patients and 58\u00a0520 age- and sex-matched controls\u201411\u00a0121 (15.2%) died during the study period. Of them, 10\u00a0513 participants (94.5%) died of natural causes, including 1653 (14.5%) who died due to stroke and 8860 (79.7%) who died due to other diseases. Two hundred and fifty patients (2.2%) died by suicide. Stroke patients showed higher adjusted hazard ratios (HR) for all-cause (HR\u00a0=\u00a06.48, 95% CI, 3.87\u201310.86), all-natural-cause (HR\u00a0=\u00a02.68, 95% CI, 2.53\u20132.84), stroke (HR\u00a0=\u00a021.16, 95% CI, 17.49\u201325.61), other disease (HR\u00a0=\u00a01.69, 95% CI, 1.58\u20131.81) and suicide mortality (HR\u00a0=\u00a03.34, 95% CI, 2.24\u20134.98) than those without stroke. The effect size of stroke for suicide mortality was greater than that for other causes of mortality (except stroke mortality).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stroke was associated with a higher risk of all-cause, natural cause and suicide mortality; stroke was more strongly associated with risk of suicide mortality than with any mortality for any other causes. From a policy standpoint, these results suggest the need for greater supportive care to prevent unnatural deaths among stroke patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pubmed\/fdac011","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:10:34Z","timestamp":1645704634000},"page":"66-74","source":"Crossref","is-referenced-by-count":2,"title":["Associations of stroke with all-cause and cause-specific mortality: A population-based matched cohort study"],"prefix":"10.1093","volume":"45","author":[{"given":"Juyeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Public Health , Sahmyook University, Seoul 01795, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Health Services Research , Yonsei University, Seoul 03722, Republic of Korea"},{"name":"Department of Preventive Medicine , Yonsei University College of Medicine, Seoul 10711, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5853\/jos.2013.15.1.2","article-title":"Stroke statistics in Korea: part I. epidemiology and risk factors: a report from the korean stroke society and clinical research center for stroke","volume":"15","author":"Hong","year":"2013","journal-title":"J Stroke"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1161\/STROKEAHA.109.554055","article-title":"Risk of hip\/femur fracture after stroke: a population-based case-control study","volume":"40","author":"Pouwels","year":"2009","journal-title":"Stroke"},{"key":"2023031519213262200_","first-page":"143","article-title":"Stroke-incidence, mortality, morbidity and risk","volume":"36","author":"Ingall","year":"2004","journal-title":"J Insur Med"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3961\/jpmph.2009.42.4.251","article-title":"Socioeconomic costs of stroke in Korea: estimated from the Korea national health insurance claims database","volume":"42","author":"Lim","year":"2009","journal-title":"J Prev Med Public Health"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1007\/s00415-016-8231-z","article-title":"Suicidal ideation and attempts in patients with stroke: a population-based study","volume":"263","author":"Chung","year":"2016","journal-title":"J Neurol"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/PSY.0000000000000079","article-title":"Death by suicide and other externally caused injuries after stroke in Japan (1990-2010): the Japan Public Health Center-based prospective study","volume":"76","author":"Yamauchi","year":"2014","journal-title":"Psychosom Med"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/jamapsychiatry.2016.1932","article-title":"Incidence of depression after stroke, and associated risk factors and mortality outcomes, in a large cohort of Danish patients","volume":"73","author":"Jorgensen","year":"2016","journal-title":"JAMA Psychiat"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/WNL.0000000000001514","article-title":"Poststroke suicide attempts and completed suicides: a socioeconomic and nationwide perspective","volume":"84","author":"Eriksson","year":"2015","journal-title":"Neurology"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11940-002-0013-5","article-title":"Suicide in neurologic illness","volume":"4","author":"Arciniegas","year":"2002","journal-title":"Curr Treat Options Neurol"},{"key":"2023031519213262200_","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1755-5949.2012.00364.x","article-title":"Do stroke patients have an increased risk of developing suicidal ideation or dying by suicide? 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