{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:24:57Z","timestamp":1777328697718,"version":"3.51.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ODIN","award":["613977"],"award-info":[{"award-number":["613977"]}]},{"name":"EarlyNutrition","award":["289346"],"award-info":[{"award-number":["289346"]}]},{"name":"European Union\u2019s Seventh Framework Programme","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}]},{"name":"NIHR Musculoskeletal Biomedical Research Unit, University of Oxford"},{"DOI":"10.13039\/100010417","name":"University of Southampton and University Hospital Southampton NHS Foundation Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010417","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute for Health Research (NIHR) Southampton Biomedical Research Centre"},{"DOI":"10.13039\/501100000355","name":"Bupa Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000355","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_21001"],"award-info":[{"award-number":["MC_PC_21001"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_21003"],"award-info":[{"award-number":["MC_PC_21003"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["17702"],"award-info":[{"award-number":["17702"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Observational studies relating maternal 25-hydroxyvitamin D status to timing and mode of delivery have reported inconsistent results. We assessed the effect of antenatal cholecalciferol supplementation on the incidence of preterm birth, delivery mode and post-partum haemorrhage (PPH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MAVIDOS was a randomized, double-blind, placebo-controlled trial of 1000\u00a0IU\/day cholecalciferol from 14\u00a0weeks\u2019 gestation until delivery. Gestational age, mode of delivery [categorized as spontaneous vaginal delivery (SVD), instrumental (including forceps and vacuum extraction) or Caesarean section] and PPH (&amp;gt;500\u00a0ml estimated blood loss) were determined from medical records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 965 women participated in the study until delivery. Gestation at birth and incidence of preterm birth (cholecalciferol 5.7%, placebo 4.5%, P\u00a0=\u00a00.43) were similar between the two treatment groups. SVD (versus instrumental or Caesarean delivery) was more likely in women randomized to cholecalciferol [Relative Risk (RR) 1.13, 95% confidence interval (CI) 1.02,1.25] due to lower instrumental (RR 0.68, 95%CI 0.51,0.91) but similar risk of Caesarean delivery (RR 0.94, 95%CI 0.74,1.19). PPH was less common in women randomized to cholecalciferol [32.1% compared with placebo (38.1%, P\u00a0=\u00a00.054) overall], but similar when stratified by delivery mode.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Antenatal cholecalciferol supplementation did not alter timing of birth or prevalence of preterm birth but demonstrated a possible effect on the likelihood of SVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdac160","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T07:21:56Z","timestamp":1672471316000},"page":"738-747","source":"Crossref","is-referenced-by-count":7,"title":["Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-2284","authenticated-orcid":false,"given":"Rebecca J","family":"Moon","sequence":"first","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"},{"name":"Paediatric Endocrinology, University Hospital Southampton National Health Service (NHS) Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah R","family":"Crozier","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M","family":"Curtis","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Fernandes","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra J","family":"Kermack","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin H","family":"Davies","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, University Hospital Southampton National Health Service (NHS) Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith M","family":"Godfrey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"},{"name":"NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J","family":"Bishop","sequence":"additional","affiliation":[{"name":"Academic Unit of Child Health, Sheffield Children\u2019s Hospital, University of Sheffield , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women\u2019s & Reproductive Health, John Radcliffe Hospital, University of Oxford , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Prentice","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit, University of Cambridge, previously at MRC Human Nutrition Research, Elsie Widdowson Laboratory , Cambridge , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inez","family":"Schoenmakers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Medicine, University of East Anglia , Norwich , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Sheffield Hospitals NHS Trust, University of Sheffield , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh V","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Sheffield Hospitals NHS Trust, University of Sheffield , Sheffield , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazel M","family":"Inskip","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"},{"name":"NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Kassim","family":"Javaid","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Centre, University of Oxford , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris T","family":"Papageorghiou","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women\u2019s & Reproductive Health, John Radcliffe Hospital, University of Oxford , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"},{"name":"NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton , UK"},{"name":"National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Centre, University of Oxford , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-2512","authenticated-orcid":false,"given":"Nicholas C","family":"Harvey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton , Southampton , UK"},{"name":"NIHR Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton , 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