{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:28:54Z","timestamp":1784942934622,"version":"3.55.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To ensure the effective delivery of latent tuberculosis infection (LTBI) care, it is vital to overcome potential challenges in LTBI management. This systematic review aims to identify the barriers and interventions to improve LTBI management using the Capability, Opportunity, and Motivation-Behaviour (COM-B) model and Behaviour Change Wheel (BCW).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic literature search was performed on five electronic databases from database inception to 3 November 2021. A two-step technique was used in the data synthesis process: (i) the barriers of LTBI management were identified using the COM-B model, followed by (ii) mapping of intervention functions from BCW to address the identified barriers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-seven eligible articles were included in this review. The findings highlighted the need for a multifaceted approach in tackling the barriers in LTBI management across the public, provider and system levels. The barriers were summarized into suboptimal knowledge and misperception of LTBI, as well as stigma and psychosocial burden, which could be overcome with a combination of intervention functions, targeting education, environment restructuring, persuasion, modelling, training, incentivization and enablement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The remedial strategies using BCW to facilitate policy reforms in LTBI management could serve as a value-added initiative in the global tuberculosis control and prevention program.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdad051","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T08:01:24Z","timestamp":1683360084000},"page":"e447-e466","source":"Crossref","is-referenced-by-count":15,"title":["How can we improve latent tuberculosis infection management using behaviour change wheel: a systematic review"],"prefix":"10.1093","volume":"45","author":[{"given":"Yen Jun","family":"Wong","sequence":"first","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia , Jalan Lagoon Selatan, 47500 Subang Jaya, Selangor , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuen Yen","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia , Jalan Lagoon Selatan, 47500 Subang Jaya, Selangor , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun Wen Huey","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia , Jalan Lagoon Selatan, 47500 Subang Jaya, Selangor , Malaysia"},{"name":"School of Pharmacy, Taylor\u2019s University Lakeside Campus , Jalan Taylors, 47500 Subang Jaya, Selangor , Malaysia"},{"name":"Center of Global Health , Perelman School of Medicine, , Philadelphia, PA 19104 , USA"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"2023083123203002400_ref1","volume-title":"Global Tuberculosis Report 2022","author":"World Health Organization","year":"2022"},{"issue":"1","key":"2023083123203002400_ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13012-017-0561-4","article-title":"Identifying barriers to and facilitators of tuberculosis contact investigation in Kampala, Uganda: a behavioral approach","volume":"12","author":"Ayakaka","year":"2017","journal-title":"Implementation Sci"},{"issue":"1","key":"2023083123203002400_ref3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13012-020-01061-4","article-title":"Improving case detection of tuberculosis in hospitalised Kenyan children\u2014employing the behaviour change wheel to aid intervention design and implementation","volume":"15","author":"Oliwa","year":"2020","journal-title":"Implementation Sci"},{"issue":"1","key":"2023083123203002400_ref4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1748-5908-6-42","article-title":"The behaviour change wheel: a new method for characterising and designing behaviour change interventions","volume":"6","author":"Michie","year":"2011","journal-title":"Implementation Sci"},{"key":"2023083123203002400_ref5","volume-title":"The END TB Strategy","author":"World Health Organization","year":"2015"},{"issue":"10","key":"2023083123203002400_ref6","doi-asserted-by":"crossref","first-page":"e1002152","DOI":"10.1371\/journal.pmed.1002152","article-title":"The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling","volume":"13","author":"Houben","year":"2016","journal-title":"PLoS Med"},{"key":"2023083123203002400_ref7","doi-asserted-by":"crossref","first-page":"100142","DOI":"10.1016\/j.jctube.2020.100142","article-title":"Identifying gaps in the quality of latent tuberculosis infection care","volume":"18","author":"Hannah","year":"2020","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"issue":"8","key":"2023083123203002400_ref8","article-title":"Latent tuberculosis infection: misperceptions among non-U.S.\u2013born-populations from countries where tuberculosis is common. 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