{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:51:23Z","timestamp":1781218283541,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>efficacy of therapeutic cholecalciferol supplementation for severe COVID-19 is sparingly studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>effect of single high-dose cholecalciferol supplementation on sequential organ failure assessment (SOFA) score in moderate-to-severe COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>participants with moderate to severe COVID-19 with PaO2\/FiO2 ratio\u00a0&amp;lt;\u00a0200 were randomized to 0.6 million IU cholecalciferol oral (intervention) or placebo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcomes<\/jats:title>\n                  <jats:p>primary outcome was change in Day 7 SOFA score and pre-specified secondary outcomes were SOFA and 28-day all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>in all, 90 patients (45 each group) were included for intention-to-treat analysis. 25(OH)D3 levels were 12 (10\u201316) and 13 (12\u201318) ng\/ml (P\u00a0=\u00a00.06) at baseline; and 60 (55\u201365) ng\/ml and 4 (1\u20137) ng\/ml by Day 7 in vitamin D and placebo groups, respectively. The SOFA score on Day 7 was better in the vitamin D group [3 (95% CI, 2\u20135) versus 5 (95% CI, 3\u20137), P\u00a0=\u00a00.01, intergroup difference\u00a0\u2212\u00a02 (95% CI, \u22124 to \u22120.01); r\u00a0=\u00a00.4]. A lower all-cause 28-day mortality [24% compared to 44% (P\u00a0=\u00a00.046)] was observed with vitamin D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>single high-dose oral cholecalciferol supplementation on ICU admission can improve SOFA score at Day 7 and reduce in-hospital mortality in vitamin D-deficient COVID-19.<\/jats:p>\n                  <jats:p>ClinicalTrials.gov \u00a0id: NCT04952857 registered dated 7 July 2021.<\/jats:p>\n                  <jats:p>What is already known on this topic\u2014vitamin D has immunomodulatory role. Observational and isolated intervention studies show some benefit in COVID-19. Targeted therapeutic vitamin D supplementation improve outcomes in severe COVID-19 is not studied in RCTs.<\/jats:p>\n                  <jats:p>What this study adds\u2014high-dose vitamin D supplementation (0.6 Million IU) to increase 25(OH)D\u00a0&amp;gt;\u00a050\u00a0ng\/ml is safe and reduces sequential organ failure assessment score, in-hospital mortality in moderate to severe COVID-19.<\/jats:p>\n                  <jats:p>How this study might affect research, practice or policy\u2014vitamin D supplementation in vitamin D-deficient patients with severe COVID-19 is useful may be practiced.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdae007","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:27:09Z","timestamp":1706689629000},"page":"256-266","source":"Crossref","is-referenced-by-count":19,"title":["Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled 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