{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:47:46Z","timestamp":1741153666097,"version":"3.38.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although there is evidence that sitting time (ST) and insufficient physical activity (PA) are associated with premature mortality, the burden of cardiovascular disease (CVD) and all-cause mortality (ACM) attributable to the combined effects of ST and PA in counterfactual scenarios is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Potential impact fractions (PIFs) were used to calculate premature deaths (PDs) and disability-adjusted life years (DALYs). Cause-eliminated life tables were utilized to estimate health-adjusted life expectancy (HALE) gains. Monte Carlo simulations were performed for uncertainty analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The theoretical minimum risk exposure level (ST &amp;lt;\u20094 $\\mathrm{h} \\cdot{\\mathrm{d}}^{-1}$, PA &amp;gt;\u200965 $\\mathrm{min} \\cdot{\\mathrm{d}}^{-1}$) could prevent 16.7% of CVD deaths and 12.3% of all-cause deaths annually. This would save 669 to 2,630 DALYs per 100,000 and increase healthy life years by 0.57 to 2.94. Increasing PA to &amp;gt;\u200965 $\\mathrm{min} \\cdot{\\mathrm{d}}^{-1}$ while maintaining ST could yield gains in HALE from 0.49 (CVD) to 2.60 (ACM) years. Reducing ST to &amp;lt;\u20094 $\\mathrm{h}\\cdot{\\mathrm{d}}^{-1}$ while keeping PA constant could lead to gains in HALE from 0.07 (CVD) to 0.34 (ACM) years. A 50% reduction in suboptimal ST (\u2265 4 $\\mathrm{h}\\cdot{\\mathrm{d}}^{-1}$) doubled HALE gains, ranging from 0.11 to 0.63\u00a0years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Public health decision-makers should prioritize vulnerable populations, including older adults and individuals with inadequate PA levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdae291","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:34:57Z","timestamp":1732152897000},"page":"e28-e37","source":"Crossref","is-referenced-by-count":0,"title":["Comparative risk assessment modeling of cardiovascular and all-cause burden attributable to sitting time and physical inactivity: evidence from Argentina"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-0521","authenticated-orcid":false,"given":"Christian","family":"Garc\u00eda-Witulski","sequence":"first","affiliation":[{"name":"Centro de Desarrollo Humano Sostenible, Facultad de Ciencias Econ\u00f3micas, Pontificia Universidad Cat\u00f3lica , Ciudad Aut\u00f3noma de Buenos Aires,","place":["Argentina"]},{"name":"Universidad Esp\u00edritu Santo , Samborond\u00f3n,","place":["Ecuador"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"2025030421253359400_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30211-4","article-title":"Use of the prevented fraction for the population to determine deaths averted by existing prevalence of physical activity: a descriptive study. 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