{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:47:52Z","timestamp":1741153672006,"version":"3.38.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Understanding of the factors influencing oesophageal cancer trends is crucial. Therefore, this cross-sectional cohort study sought to disentangle the age, period and cohort effects on the trends of oesophageal cancer in Kuwait.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The data on incident oesophageal carcinoma cases diagnosed between January 1, 1980, through December 31, 2019, and reference population were obtained. Age-period-cohort (APC) analysis was conducted using a loglinear Poisson regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 496 oesophageal carcinoma cases in 12.8 million person-years (i.e. squamous-cell carcinoma, 269, 54.23%), adenocarcinoma,147, 29.64% and unspecified cases, 80,16.13%) were diagnosed. The overall age-standardized incidence rate (per 105 person-years) of oesophageal carcinoma during the study period was 10.51 (95% CI: 6.62\u201314.41). The APC analysis results showed that the age and birth cohort effects were the significant determinants of declining, and subsequently steadying the oesophageal carcinoma incidence rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A substantial decline in oesophageal carcinoma incidence rates was recorded, which significantly varied in all three temporal dimensions. The observed birth cohort patterns suggest changing lifestyle and dietary patterns seem to be responsible for decreasing oesophageal carcinoma risk in Kuwait. Future studies may look for the component causes maintaining the endemicity of oesophageal carcinoma risk in this and similar countries in the region.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdae311","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T02:30:21Z","timestamp":1734229821000},"page":"e59-e66","source":"Crossref","is-referenced-by-count":0,"title":["Age-period-cohort modeling of oesophageal carcinoma risk in a middle eastern country: 1980\u20132019"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-788X","authenticated-orcid":false,"given":"Saeed","family":"Akhtar","sequence":"first","affiliation":[{"name":"Department of Community Medicine and Behavioural Sciences , College of Medicine, , PO Box 24923, Safat 13110,","place":["Kuwait"]},{"name":"Kuwait University , College of Medicine, , PO Box 24923, Safat 13110,","place":["Kuwait"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Al-Shammari","sequence":"additional","affiliation":[{"name":"Department of Surgery , Faculty of Medicine, , 1001 Decarie Boulevard, Montreal, QC H4A 3J1,","place":["Canada"]},{"name":"McGill University , Faculty of Medicine, , 1001 Decarie Boulevard, Montreal, QC H4A 3J1,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al-Huraiti","sequence":"additional","affiliation":[{"name":"Ministry of Health , Jamal Abdel Nasser Street, Sulaibkhat 13001,","place":["Kuwait"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouzan","family":"Al-Anjery","sequence":"additional","affiliation":[{"name":"Ministry of Health , Jamal Abdel Nasser Street, Sulaibkhat 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