{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:08:17Z","timestamp":1778216897647,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Screening and Early Diagnosis","award":["NIHR206132"],"award-info":[{"award-number":["NIHR206132"]}]},{"DOI":"10.13039\/501100007602","name":"NIHR Programme Grants for Applied Research","doi-asserted-by":"publisher","award":["NIHR201070"],"award-info":[{"award-number":["NIHR201070"]}],"id":[{"id":"10.13039\/501100007602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the likelihood of attributing colorectal cancer (CRC) symptoms to medications for chronic conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The online vignette survey included 1287 participants aged \u226550\u00a0years, with quota sampling to recruit sufficient participants with type 2 diabetes. Participants self-reported chronic conditions and answered questions on symptom attribution and help-seeking, after reading vignettes describing new-onset rectal bleeding or change in bowel habit. Using multivariable logistic regression, we analyzed the association between specific conditions and attributing new-onset CRC symptoms to medications, controlling for demographics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among participants, 25% reported type 2 diabetes, 31% being overweight, 25% hypertension and 22% arthritis. Participants with diabetes, versus those without, had a higher likelihood of attributing change in bowel habit to medications [7% vs 3%; adjusted Odds Ratio (aOR) 2.55, Confidence Interval (95% CI) 1.30\u20135.00]. This was also the case for participants reporting being overweight (7% vs 2%; aOR 2.36, 95% CI 1.25\u20134.44), arthritis (8% vs 3%; aOR 2.27, 95% CI 1.19\u20134.35), but not for hypertension. No significant association was found regarding attribution of rectal bleeding to medications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with common chronic conditions have a higher likelihood of attributing change in bowel habit to medications. Tailored information is needed for these patients, encouraging them to discuss any new symptom with their doctor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdaf014","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T16:16:10Z","timestamp":1740068170000},"page":"144-148","source":"Crossref","is-referenced-by-count":5,"title":["Attribution of colorectal cancer symptoms to medications for pre-existing chronic conditions: a secondary analysis of a vignette study in England"],"prefix":"10.1093","volume":"47","author":[{"given":"Giovanni E","family":"Ricciardi","sequence":"first","affiliation":[{"name":"PhD National Programme in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia , Pavia 27100 ,","place":["Italy"]},{"name":"School of Medicine, Universit\u00e0 Vita-Salute San Raffaele , via Olgettina, 58, 20132, Milano ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Pennisi","sequence":"additional","affiliation":[{"name":"PhD National Programme in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia , Pavia 27100 ,","place":["Italy"]},{"name":"School of Medicine, Universit\u00e0 Vita-Salute San Raffaele , via Olgettina, 58, 20132, Milano ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Von Wagner","sequence":"additional","affiliation":[{"name":"Epidemiology of Cancer Healthcare & Outcomes (ECHO), Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IEHC), University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Smith","sequence":"additional","affiliation":[{"name":"Epidemiology of Cancer Healthcare & Outcomes (ECHO), Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IEHC), University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aradhna","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Epidemiology of Cancer Healthcare & Outcomes (ECHO), Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IEHC), University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A","family":"Abel","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School, Department of Health and Community Sciences, Faculty of Health and Life Sciences, University of Exeter , St Luke\u2019s Campus, Heavitree Road, Exeter EX1 2LU \u00a0","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Lyratzopoulos","sequence":"additional","affiliation":[{"name":"Epidemiology of Cancer Healthcare & Outcomes (ECHO), Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IEHC), University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Renzi","sequence":"additional","affiliation":[{"name":"School of Medicine, Universit\u00e0 Vita-Salute San Raffaele , via Olgettina, 58, 20132, Milano ,","place":["Italy"]},{"name":"Epidemiology of Cancer Healthcare & Outcomes (ECHO), Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IEHC), University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"2025053004273718100_ref1","volume-title":"Cancer Research UK, London","author":"Cancer Research UK. 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