{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:42:05Z","timestamp":1792755725303,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although antiretroviral therapy (ART) coverage has increased, significant gaps in adherence and viral suppression persist, particularly in vulnerable settings such as Meta (Colombia), where armed conflict and barriers to healthcare access exacerbate the epidemic. This study examined sociodemographic and clinical factors associated with ART adherence and viral suppression in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An analytical cross-sectional study was conducted with 155 people living with HIV. The Simplified Medication Adherence Questionnaire was applied, and clinical data were extracted from medical records. Associations were analyzed using bivariate and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants, 73 (47.1%) were non-adherent to ART and 31 (20%) did not achieve viral suppression. Both non-adherence and viral non-suppression were associated with demographic, behavioral, clinical, and ART-related aspects. In the multivariable analysis, ART side effects [odds ratios (OR)\u00a0=\u00a00.360; P\u00a0=\u00a0.015] and PAS use (OR\u00a0=\u00a011.375; P\u00a0=\u00a0.032) were predictors of non-adherence. Likewise, participation in sex work (OR\u00a0=\u00a04.334; P\u00a0=\u00a0.029) and lack of dietary modifications (OR\u00a0=\u00a03.176; P\u00a0=\u00a0.046) predicted viral non-suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeted interventions addressing both clinical and psychosocial determinants are essential to improve adherence, achieve sustained viral suppression, and reduce HIV transmission in highly vulnerable contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pubmed\/fdaf121","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:58:51Z","timestamp":1758841131000},"page":"679-690","source":"Crossref","is-referenced-by-count":1,"title":["Determinants associated with non-adherence to antiretroviral therapy (ART) and viral load suppression in PLHIV in Meta, Colombia"],"prefix":"10.1093","volume":"47","author":[{"given":"Cort\u00e9s-Gonz\u00e1lez Jos\u00e9","family":"Daniel","sequence":"first","affiliation":[{"name":"Asistencia Cient\u00edfica de Alta Complejidad , Villavicencio, Carrera 48 Numero 12B -36-38, 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavas-Escobar Norma","family":"Cristina","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Medicina, GRIVI (Grupo de investigaci\u00f3n de Villavicencio) , Cra. 22 N. 7-06, Villavicencio 500001 ,","place":["Colombia"]},{"name":"Secretar\u00eda de Salud del Meta, Laboratorio de Salud P\u00fablica, GISSME (Grupo de investigaci\u00f3n de la Secretaria de Salud del Meta) . Cl. 37 #41-80, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obando Bastidas","family":"Jorge","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Administraci\u00f3n de Empresas, G-DOVAZ GDOVAZ (El Grupo de Gesti\u00f3n de Desarrollo Organizacional, Contable, de Aseguramiento y de Objetos Virtuales de Aprendizaje , Cl. 37 #41-80, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garc\u00eda-Balaguera","family":"Cesar","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Medicina, GRIVI (Grupo de investigaci\u00f3n de Villavicencio) , Cra. 22 N. 7-06, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delgado Andrade Samara","family":"Valeria","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud del Meta, Laboratorio de Salud P\u00fablica, GISSME (Grupo de investigaci\u00f3n de la Secretaria de Salud del Meta) . Cl. 37 #41-80, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acosta Zapata","family":"Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de derecho, HUMANITAS IURIS , Carrera 73 # 2a-80. Cali 760033 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perez-Guti\u00e9rrez","family":"Norton","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Medicina, GRIVI (Grupo de investigaci\u00f3n de Villavicencio) , Cra. 22 N. 7-06, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cocunubo","family":"Nancy","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Medicina, GRIVI (Grupo de investigaci\u00f3n de Villavicencio) , Cra. 22 N. 7-06, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernal-Vargas","family":"Liliana","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Psicolog\u00eda, PROMETEO , Calle 11 # 66 B - 17, Villavicencio 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sussmann Pe\u00f1a Otto","family":"Alberto","sequence":"additional","affiliation":[{"name":"Asistencia Cient\u00edfica de Alta Complejidad , Villavicencio, Carrera 48 Numero 12B -36-38, 500001 ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montilla Rodr\u00edguez Liliana","family":"Marcela","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia, Facultad de Medicina, GRIVI (Grupo de investigaci\u00f3n de Villavicencio) , Cra. 22 N. 7-06, Villavicencio 500001 ,","place":["Colombia"]},{"name":"Secretar\u00eda de Salud del Meta, Laboratorio de Salud P\u00fablica, GISSME (Grupo de investigaci\u00f3n de la Secretaria de Salud del Meta) . 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