{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:02:16Z","timestamp":1780308136160,"version":"3.54.0"},"reference-count":122,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of South Australia\u2013Enterprise Research Scholarship"},{"name":"Medical Research Future Fund of Australia","award":["2007431"],"award-info":[{"award-number":["2007431"]}]},{"name":"National Health and Medical Research Council Leadership Award","award":["GNT 2025349"],"award-info":[{"award-number":["GNT 2025349"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian cancer (OC) remains a major global health issue, often diagnosed late and lacking effective screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MR studies until 11 September 2023 were identified by a systematic search across nine databases. We complied with PRISMA guidelines and included different OC subtypes and all exposures studied, conducting meta-analyses where feasible to combine estimates from non-overlapping samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 120 articles examining genetic evidence for an association between 230 exposures and OC risk. Endometriosis, late age at menopause, and several adiposity measures were robustly associated with greater OC risk. In contrast, late age at menarche, higher adiponectin, and body fat without adverse metabolic profile were associated with lower risk (favourable adiposity: meta-analysis OR per SD 0.35, 95% CI 0.20\u20130.61). Meta-analyses on lipid-lowering drug target HMG-CoA reductase inhibitor (OR 0.66, 95% CI 0.53\u20130.82), serum vitamin D (OR 0.88, 95% CI 0.82\u20130.95), and dried fruit intake (HR 0.61, 95% CI 0.41\u20130.91) were supportive of protective associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genetic evidence confirms OC risks associated with endometriosis, and age at menarche and menopause. While greater overall adiposity increases the risk, fat without an adverse metabolic profile appears protective. Associations between vitamin D and HMG-CoA reductase inhibition with OC risk warrant further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pubmed\/fdag034","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:00:21Z","timestamp":1778706021000},"page":"430-443","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-2523","authenticated-orcid":false,"given":"Melaku","family":"Yalew","sequence":"first","affiliation":[{"name":"Australian Centre for Precision Health, School of Public Health, Adelaide University , North Terrace, Adelaide CBD, SA 5000 ,","place":["Australia"]},{"name":"South Australian Health and Medical Research Institute , North Terrace, Adelaide, SA 5000 ,","place":["Australia"]},{"name":"Department of Public Health, 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K","family":"Oehler","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Royal Adelaide Hospital , Port Road, Adelaide, SA 5000 ,","place":["Australia"]},{"name":"Adelaide Medical School, Robinson Research Institute, Adelaide University , North Terrace, Adelaide, SA 5006 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-6912","authenticated-orcid":false,"given":"Johanna","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Medical Technology, Tampere University , Arvo Ylp\u00f6n katu, 33014 Tampere ,","place":["Finland"]},{"name":"Cancer Centre, Tampere University and University Hospital , El\u00e4m\u00e4naukio, 33520 Tampere 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