{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:13:37Z","timestamp":1788272017363,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0503000"],"award-info":[{"award-number":["2023ZD0503000"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0503004"],"award-info":[{"award-number":["2023ZD0503004"]}]},{"name":"Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China","award":["JYB2025XDXM607"],"award-info":[{"award-number":["JYB2025XDXM607"]}]},{"name":"Institutional Joint Innovation Fund from Sichuan University and Nuclear Power Institute of China","award":["LHCX-2024-JJ"],"award-info":[{"award-number":["LHCX-2024-JJ"]}]},{"name":"Sichuan Science and Technology Program","award":["2025YFHZ0087"],"award-info":[{"award-number":["2025YFHZ0087"]}]},{"name":"Science and Technology Project of Sichuan Provincial Health Commission","award":["JH2023082"],"award-info":[{"award-number":["JH2023082"]}]},{"name":"International Science and Technology Cooperation Program of Chengdu Science and Technology Bureau","award":["2024-YF06-00011-HZ"],"award-info":[{"award-number":["2024-YF06-00011-HZ"]}]},{"name":"International Science and Technology Cooperation Program of Chengdu Science and Technology Bureau","award":["2022-GH03-00004-HZ"],"award-info":[{"award-number":["2022-GH03-00004-HZ"]}]},{"name":"Health Research Project of Chengdu Eastern New Area Management Committee","award":["202304"],"award-info":[{"award-number":["202304"]}]},{"name":"West China Hospital of Sichuan University","award":["ZYYC23006"],"award-info":[{"award-number":["ZYYC23006"]}]},{"name":"Clinical Research Incubation Project of West China Hospital","award":["23HXFH001"],"award-info":[{"award-number":["23HXFH001"]}]},{"name":"Clinical Research Youth Fund of West China Hospital","award":["2025HXFH028"],"award-info":[{"award-number":["2025HXFH028"]}]},{"name":"West China Hospital ``Qimingxing'' Research Fund for Young Talents","award":["HXQMX0184"],"award-info":[{"award-number":["HXQMX0184"]}]},{"name":"Yunnan Province Key Laboratory of Precision Diagnosis and Treatment for Thoracic Diseases","award":["202449CE340026"],"award-info":[{"award-number":["202449CE340026"]}]},{"name":"National Key R&D\u00b7Program of China","award":["2023YFC3403200"],"award-info":[{"award-number":["2023YFC3403200"]}]},{"name":"Ministry of Education University-Industry Collaborative Education Program","award":["230720523707281"],"award-info":[{"award-number":["230720523707281"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibiotics are among the most frequently prescribed medications worldwide. However, previous studies have yielded inconsistent findings regarding the association between antibiotic exposure and the risk of various cancers, and the credibility of the available evidence remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an umbrella review based on published meta-analyses and systematic reviews to evaluate the association between past or current antibiotic exposure and cancer risk. PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to November 2025. Pooled effect sizes were obtained utilizing random-effects models. The credibility of evidence was evaluated utilizing the GRADE framework. All analyses were analyzed utilizing the R package \u201cmetaumbrella\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>10 articles encompassing 14 cancer types and 66 distinct associations were included. 9 associations were classified as highly suggestive evidence, 7 as suggestive evidence, and 21 as weak evidence. Among associations for which the evidence reached the highly suggestive level, antibiotic exposure was associated with increased risks of proximal colon cancer, pancreatic cancer, kidney cancer, and bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Antibiotic exposure may be related to cancer risk in a cancer type-specific manner. These findings provide a higher-level evidence synthesis to inform future research directions and hypothesis generation in this field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pubmed\/fdag051","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:36:31Z","timestamp":1782495391000},"page":"661-669","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic exposure and cancer risk: an umbrella review elucidating the direction of risk across 14 malignancies"],"prefix":"10.1093","volume":"48","author":[{"given":"Tu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"College of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine , No. 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyan","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-718X","authenticated-orcid":false,"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 ,","place":["China"]},{"name":"Nuclear Physics and Medical Research Key Laboratory of Sichuan Province, Sichuan University , No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041 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