{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:52:26Z","timestamp":1793649146025,"version":"4.5.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Stenotrophomonas maltophilia is a bacteria whose role in patients with cystic fibrosis (CF) bronchiectasis has been previously studied; little is known about its role in non-CF bronchiectasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>Aim of our study is to investigate the risk factors for S. maltophilia acquisition and its clinical impact on bronchiectasis patients. A retrospective observational cohort study enrolling patients attending the Bronchiectasis Clinic at the Royal Infirmary of Edinburgh, Scotland, UK. A total of 167 bronchiectasis patients undergoing intravenous (IV) antibiotic therapy were selected and divided according to single or chronic S. maltophilia isolation in sputum. The risk factors and prognostic impact were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Single isolation was independently associated with lower baseline % predicted forced expiratory volume in 1\u2009s [odds ratio (OR) 0.98; 95% confidence interval (CI) 0.970\u20131.044; P\u2009=\u20090.025] and with less radiological involvement (OR 0.379; 95% CI 0.175\u20130.819; P\u2009=\u20090.01). Chronic isolation was associated with the number of IV antibiotic courses in the year before and after the first isolation (OR 1.2; 95% CI 1.053\u20131.398; P\u2009=\u20090.007) and with the absence of Pseudomonas aeruginosa colonization (OR 0.207; 95% CI 0.056\u20130.764; P\u2009=\u20090.02). In the chronic isolation group, there were more exacerbations and more need of IV antibiotics in the year after the first isolation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Poor lung function is the main independent risk factor for single isolation of S. maltophilia. For chronic colonization, the main independent risk factor is the number of IV antibiotic courses and the absence of P. aeruginosa chronic colonization. Only when chronically present, S. maltophilia had a clinical impact with more exacerbations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaa120","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T19:10:18Z","timestamp":1585941018000},"page":"726-730","source":"Crossref","is-referenced-by-count":15,"title":["Role of Stenotrophomonas maltophilia isolation in patients with non-CF bronchiectasis"],"prefix":"10.1093","volume":"113","author":[{"given":"R","family":"Marra","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sgalla","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, UOC Pneumologia, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d IRCCS, Largo A. Gemelli 8, Rome 00168, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Richeldi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy"},{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, UOC Pneumologia, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d IRCCS, Largo A. Gemelli 8, Rome 00168, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E G","family":"Conte","sequence":"additional","affiliation":[{"name":"Pulmonology Unit, \u201cC. & G. Mazzoni\u201d Hospital, Via degli Iris 1, Ascoli Piceno 63100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Hill","sequence":"additional","affiliation":[{"name":"Royal Infirmary and University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"2020100913444600000_hcaa120-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhin.2004.01.033","article-title":"Stenotrophomonas maltophilia: the significance and role as a nosocomial pathogen","volume":"57","author":"Senol","year":"2004","journal-title":"J Hosp Infect"},{"key":"2020100913444600000_hcaa120-B2","first-page":"2","article-title":"Stenotrophomonas maltophilia: an emerging global opportunistic pathogen","volume":"25","author":"Brooke","year":"2012"},{"key":"2020100913444600000_hcaa120-B3","doi-asserted-by":"crossref","first-page":"1700629","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur Respir J"},{"key":"2020100913444600000_hcaa120-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thoraxjnl-2018-212463","article-title":"British Thoracic Society guideline for bronchiectasis in adults","volume":"74","author":"T Hill","year":"2019","journal-title":"Thorax"},{"key":"2020100913444600000_hcaa120-B5","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/ppul.23781","article-title":"Incident Stenotrophomonas maltophilia infection and lung function decline in cystic fibrosis","volume":"52","author":"Barsky","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"2020100913444600000_hcaa120-B6","first-page":"426","article-title":"Stenotrophomonas maltophilia: a marker of lung disease severity","volume":"53","author":"Berdah","year":"2018"},{"key":"2020100913444600000_hcaa120-B7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrmicro2259","article-title":"Bacterial competition: surviving and thriving in the microbial jungle","volume":"8","author":"Hibbing","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"2020100913444600000_hcaa120-B8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1099\/mic.0.2006\/004077-0","article-title":"Microbial ecology of the cystic fibrosis lung","volume":"153","author":"Harrison","year":"2007","journal-title":"Microbiology"},{"key":"2020100913444600000_hcaa120-B9","doi-asserted-by":"crossref","first-page":"e00457","DOI":"10.1128\/IAI.00457-19","article-title":"Stenotrophomonas maltophilia encodes a VirB\/VirD4 type IV secretion system that modulates apoptosis in human cells and promotes competition against heterologous bacteria, including Pseudomonas aeruginosa","volume":"87","author":"Nas","year":"2019","journal-title":"Infect Immun"},{"key":"2020100913444600000_hcaa120-B10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3389\/fmicb.2015.00951","article-title":"Cooperative pathogenicity in cystic fibrosis: Stenotrophomonas maltophilia modulates Pseudomonas aeruginosa virulence in mixed biofilm","volume":"6","author":"Pompilio","year":"2015","journal-title":"Front Microbiol"}],"container-title":["QJM: An International Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/qjmed\/advance-article-pdf\/doi\/10.1093\/qjmed\/hcaa120\/33157502\/hcaa120.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/qjmed\/article-pdf\/113\/10\/726\/33858896\/hcaa120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/qjmed\/article-pdf\/113\/10\/726\/33858896\/hcaa120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T17:44:59Z","timestamp":1602265499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/qjmed\/article\/113\/10\/726\/5818888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,4,10]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/qjmed\/hcaa120","relation":{},"ISSN":["1460-2725","1460-2393"],"issn-type":[{"value":"1460-2725","type":"print"},{"value":"1460-2393","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,4,10]]}}}