{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:56:05Z","timestamp":1771016165721,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004162","name":"Meath Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004162","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Vascular Neurology Research Foundation"},{"name":"Trinity College Dublin Innovation Bursary"},{"DOI":"10.13039\/501100003840","name":"Irish Institute of Clinical Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003840","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Novartis Ireland Fellowship Grant"},{"name":"Merck Serono Fellowship in Neuroscience"},{"name":"Heart Foundation Stroke Prevention Bursary"},{"name":"Bayer HealthCared Ireland"},{"name":"Verum Diagnostica"},{"name":"GmbH"},{"name":"Biogen Idec Ireland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The use of anti-epileptic drugs (AEDs) in women of childbearing age (WCBA) necessitates careful counselling regarding reproductive-related issues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>(i) To compare documentation of appropriate counselling regarding reproductive-related issues in WCBA prescribed AEDs for non-epilepsy vs. epilepsy indications, and (ii) to examine whether the frequency of counselling improved after introduction of \u2018standardized typed advice\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective audit and quality assessment and improvement programme.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed medical records of all WCBA prescribed gabapentin, pregabalin, topiramate, valproate or carbamazepine by a general neurology clinical service before (Study period A) and after (Study period B) introduction of standardized typed passages regarding potential teratogenicity \u00b1 interactions with hormonal contraception at a university teaching hospital. The \u03c72 test or the Fisher\u2019s exact test was employed, as appropriate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In WCBA prescribed AEDs for non-epilepsy indications, documentation of appropriate counselling regarding potential teratogenicity improved from 49% (17\/35 patients) in Period A to 79% (27\/34 patients) in Period B (P\u2009=\u20090.008). The frequency of counselling regarding teratogenicity was higher in patients prescribed AEDs for epilepsy compared with non-epilepsy indications in Study period A (100% vs. 49%, P\u2009=\u20090.002), but was no longer significantly different in Study period B (86% vs. 79%, P\u2009=\u20090.64). Documentation of counselling regarding potential interaction of enzyme-inducing AEDs with hormonal contraception did not significantly change between study periods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Significant improvements in documentation regarding potential teratogenicity of AEDs prescribed for non-epilepsy indications can be achieved by introducing standardized, typed passages copied to patients. Such a practice change is practical and widely applicable to neurological and non-neurological practice worldwide.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaa131","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T19:12:24Z","timestamp":1586545944000},"page":"233-237","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the adequacy of counselling regarding reproductive-related issues in women of childbearing age on anti-epileptic drugs"],"prefix":"10.1093","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-8948","authenticated-orcid":false,"given":"O C","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"},{"name":"Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wrigley","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin 2, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Freir","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin 2, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin, D24 NR0A, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"O\u2019Dowd","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin 2, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin, D24 NR0A, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-4516","authenticated-orcid":false,"given":"D J H","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"},{"name":"Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Dublin 2, Ireland"},{"name":"Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin, D24 NR0A, Ireland"},{"name":"Department of Clinical Neurosciences, Royal Free Campus, UCL Queen Square Institute of Neurology, London, UK"},{"name":"Vascular Neurology Research Foundation, C\/O Department of Neurology, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital (AMNCH) \/ Tallaght University Hospital, Dublin D24 NR0A, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"2021072910130853700_hcaa131-B1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12916-017-0845-1","article-title":"Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes","volume":"15","author":"Veroniki","year":"2017","journal-title":"BMC 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