{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:44:18Z","timestamp":1793148258879,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies on sarcoidosis in elderly patients are scarce and none have specifically evaluated patients aged \u226575 at onset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>We aimed to analyse the characteristics of patients with sarcoidosis diagnosed after 75 and to compare them with those of younger patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Multicenter case\u2013control study comparing elderly-onset sarcoidosis (EOS) with young-onset sarcoidosis (YOS) seen at Lyon University Hospitals between 2006 and 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using our institutional database, we included 34 patients in the EOS group and compared them with 102 controls from the YOS group in a 1:3 ratio. Demographic characteristics, medical history, clinical presentation, laboratory and imaging findings, sites of biopsies, histological analyses, treatments and outcomes were recorded using a comprehensive questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were more Caucasians in the EOS group (94.1% vs. 59.8%; P\u2009&amp;lt;\u20090.001), who had significantly more comorbidities (mean, 3.1\u2009\u00b1\u20092 vs. 1.1\u2009\u00b1\u20091.6; P\u2009&amp;lt;\u20090.001). In the EOS group, there was less pulmonary involvement (26.5% vs. 49%; P\u2009=\u20090.022), less lymphadenopathy (2.9% vs. 16.7%; P\u2009=\u20090.041), no erythema nodosum (0% vs. 12.8%; P\u2009=\u20090.029) and no arthralgia (0% vs. 25.5%; P\u2009=\u20090.001). Conversely, uveitis was more common in the EOS group (55.9% vs. 20.6%; P\u2009&amp;lt;\u20090.001). Pathological confirmation was obtained significantly less frequently in the EOS group (67.7% vs. 85.3%; P\u2009=\u20090.023). Corticosteroid-related side effects were significantly more common in the EOS group (100% vs. 75.9%; P\u2009=\u20090.030).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Epidemiology and clinical presentation of EOS differs from YOS, including more comorbidities and more uveitis. Elderly patients are more prone to corticosteroid side effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaa171","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T11:31:04Z","timestamp":1591961464000},"page":"238-245","source":"Crossref","is-referenced-by-count":11,"title":["Sarcoidosis diagnosed in the elderly: a case\u2013control study"],"prefix":"10.1093","volume":"114","author":[{"given":"A","family":"Bert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University Lyon 1, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Short Stay Geriatric Unit, Lyon Sud University Hospital, University Claude Bernard University Lyon 1, 165 Chemin du Grand Revoyet, 69310 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Cottin","sequence":"additional","affiliation":[{"name":"National Reference Center for Rare Pulmonary Diseases, Louis Pradel University Hospital, University Claude Bernard University Lyon 1, 59 Boulevard Pinel, 69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mercier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University Lyon 1, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gerfaud-Valentin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University Lyon 1, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Durieu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lyon Sud University Hospital, University Claude Bernard University Lyon 1, 165 Chemin du Grand Revoyet, 69310 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Edouard Herriot University Hospital, University Claude Bernard University Lyon 1, 5 Place d'Arsonval, 69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hicks","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Varron","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mont\u00e9limar Hospital, Quartier Beausseret, Route de Sauzet, 26200 Mont\u00e9limar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Seve","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University Lyon 1, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Jamilloux","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University Lyon 1, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"2021072910130545900_hcaa171-B1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/MCP.0000000000000075","article-title":"Advanced pulmonary 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