{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:33:17Z","timestamp":1787009597514,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Fund of Xi'an Medical College","award":["2016HXKF01"],"award-info":[{"award-number":["2016HXKF01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to conduct a systematic review of the diagnostic value of interleukin-27 (IL-27) for tuberculous pleurisy (TP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature on IL-27 diagnosis of TP was retrieved and screened from six databases (four English databases and two Chinese databases). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and summary receiver operating characteristic curve (SROC) were measured to assess accurately the comprehensive evaluation of IL-27 for TP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies with a total of 1454 patients were identified in the analysis. The combined diagnostic value of IL-27 for TP was as follows: sensitivity of 0.95 (95% confidence interval [CI]: 0.93\u20130.97), specificity of 0.91 (95% CI: 0.89\u20130.92), positive likelihood ratio of 13.99 (95% CI: 7.01\u201327.93), negative likelihood ratio of 0.07 (95% CI: 0.05\u20130.10), diagnostic odds ratio of 275.20 (95% CI: 112.83\u2013671.23) and area under the SROC of 0.9830.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL-27 has an excellent diagnostic value for TP and could be used as a diagnostic biomarker for TP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/qjmed\/hcaa215","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T15:20:53Z","timestamp":1593789653000},"page":"568-576","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic accuracy of interleukin-27 in tuberculous pleurisy: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"114","author":[{"given":"Q","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi\u2019an Medical University, X\u2019ian 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Xi\u2019an Medical University, X\u2019ian 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Xi\u2019an Medical University, X\u2019ian 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Xi\u2019an Medical University, X\u2019ian 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi\u2019an Medical University, X\u2019ian 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"2021110616492262400_hcaa215-B1","year":"2019"},{"key":"2021110616492262400_hcaa215-B2","first-page":"134","article-title":"Diagnostic value of three pleural effusion detection methods for tuberculous pleurisy","volume":"53","author":"Xue-Lian","year":"2018","journal-title":"Chin J Med"},{"key":"2021110616492262400_hcaa215-B3","first-page":"1586","article-title":"Advances in laboratory diagnostic methods and detection techniques for Mycobacterium tuberculosis infection","volume":"39","author":"Zhang","year":"2019","journal-title":"Int J Respir Med"},{"key":"2021110616492262400_hcaa215-B4","first-page":"7239","article-title":"Combined evaluation of adenosine deaminase level and histopathological findings from pleural biopsy with Cope\u2019s needle for the diagnosis of tuberculous pleurisy","volume":"8","author":"Behrsin","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2021110616492262400_hcaa215-B5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1159\/000486963","article-title":"Diagnostic accuracy of interleukin-27 between tuberculous pleural effusion and malignant pleural effusion: a meta-analysis","volume":"95","author":"Liu","year":"2018","journal-title":"Respiration"},{"key":"2021110616492262400_hcaa215-B6","first-page":"1871","article-title":"Diagnostic value of T-Spot TB combined with INF-gamma and IL-27 in tuberculous pleurisy","volume":"15","author":"Zhang","year":"2017","journal-title":"Exp Ther Med"},{"key":"2021110616492262400_hcaa215-B7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/23744235.2016.1183816","article-title":"A diagnostic algorithm for tuberculous pleurisy using the ELISPOT assay on peripheral blood and pleural effusion","volume":"48","author":"Kim","year":"2016","journal-title":"Infect Dis (Lond)"},{"key":"2021110616492262400_hcaa215-B8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3109\/23744235.2015.1019919","article-title":"Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence","volume":"47","author":"Skouras","year":"2015","journal-title":"Infect Dis"},{"key":"2021110616492262400_hcaa215-B9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.rmed.2010.02.025","article-title":"Diagnosing tuberculous pleural effusion using clinical data and pleural fluid analysis. 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