{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:53:19Z","timestamp":1792572799400,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Kyasanur forest disease (KFD) virus is a flavivirus that can be transmitted to humans from monkeys or other mammals through hard ticks (Haemaphysalis spinigera). The disease is endemic to 16 districts in 5 states of Southern India and is reported in the dry season, most commonly in humans travelling to the forests in these areas. The aim of this systematic review is to raise awareness of the clinical and laboratory manifestation of KFD among physicians and travel medicine practitioners. A total of 153 articles were screened of which 16 articles that met the inclusion and exclusion criteria were included for qualitative analysis. KFD is an acute haemorrhagic fever with a biphasic component in some individuals. The second phase is usually marked by neurological symptoms. Leucopoenia, thrombocytopenia and elevated transaminases are the hallmarks of the first phase of KFD. The diagnostic modality of choice in the first few days of illness is polymerase chain reaction assay, whereas serology is used in the late phase. In the absence of a specific antiviral treatment, the clinical management of patients is limited to supportive care. Avoidance of exposure and vaccination is recommended to prevent this infection.<\/jats:p>","DOI":"10.1093\/qjmed\/hcaa310","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T12:27:12Z","timestamp":1604579232000},"page":"351-358","source":"Crossref","is-referenced-by-count":33,"title":["Kyasanur forest disease: a state-of-the-art review"],"prefix":"10.1093","volume":"115","author":[{"given":"N","family":"Gupta","sequence":"first","affiliation":[{"name":"From the 1Department of Infectious Diseases, Kasturba Medical College and Hospital"},{"name":"Manipal Center for Infectious Diseases, Prasanna School of Public Health, Madhav Nagar, Manipal 576104, Udupi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kasturba Medical College and Hospital, Manipal Academy of Higher Education , Madhav Nagar, Manipal 576104, Udupi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Neumayr","sequence":"additional","affiliation":[{"name":"Department of Medicine, Swiss Tropical and Public Health Institute , Basel, Switzerland"},{"name":"University of Basel , Petersplatz 1, 4001, Basel, Switzerland"},{"name":"Department of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University , Townsville, Queensland-4811, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-1129","authenticated-orcid":false,"given":"K","family":"Saravu","sequence":"additional","affiliation":[{"name":"From the 1Department of Infectious\u2002 Diseases, Kasturba Medical College and Hospital"},{"name":"Manipal Center for Infectious Diseases\u2002, Prasanna School of Public Health, Madhav Nagar, Manipal 576104, Udupi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"2022060802101954600_hcaa310-B1","first-page":"619","article-title":"Kyasanur forest disease. III. A preliminary report on the nature of the infection and clinical manifestations in human beings","volume":"11","author":"Work","year":"1957","journal-title":"Indian J Med Sci"},{"key":"2022060802101954600_hcaa310-B2","first-page":"1011","article-title":"Kyasanur forest disease VI. Pathological findings in three fatal human cases of Kyasanur forest disease","volume":"13","author":"Iyer","year":"1959","journal-title":"Indian J Med Sci"},{"key":"2022060802101954600_hcaa310-B3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0035-9203(61)90067-0","article-title":"Kyasanur forest disease: a general clinical study in which some cases with neurological complications were observed","volume":"55","author":"Webb","year":"1961","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2022060802101954600_hcaa310-B4","first-page":"419","article-title":"Haematological and biochemical studies in Dyasanur Forest disease","volume":"51","author":"Chatterjea","year":"1963","journal-title":"Indian J Med Res"},{"key":"2022060802101954600_hcaa310-B5","first-page":"950","article-title":"Viraemia studies on the Kyasanur Forest Disease human cases of 1966","volume":"63","author":"Upadhyaya","year":"1975","journal-title":"Indian J Med 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