{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:36:47Z","timestamp":1788183407379,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Although it is a member of the Interleukin (IL)-1 family, IL-37 is unique in that it has wide-ranging anti-inflammatory characteristics. It was originally thought to prevent IL-18-mediated inflammation by binding to the IL-18-binding protein. However, upon discovery that it binds to the orphan receptor, IL-1R8, further studies have revealed an expanded role of IL-37 to include several intracellular and extracellular pathways that affect various aspects of inflammation. Its potential role specifically in cardiovascular diseases (CVD) stemmed initially from the discovery of elevated plasma IL-37 levels in human patients with acute coronary syndrome and atrial fibrillation. Other studies using mouse models of ischemia\/reperfusion injury, vascular calcification and myocardial infarction have revealed that IL-37 can have a beneficial role in these conditions. This review will explore recent research on the effects of IL-37 on the pathogenesis of CVD.<\/jats:p>","DOI":"10.1093\/qjmed\/hcab011","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T06:46:34Z","timestamp":1610520394000},"page":"719-725","source":"Crossref","is-referenced-by-count":16,"title":["IL-37\u2014a putative therapeutic agent in cardiovascular diseases"],"prefix":"10.1093","volume":"115","author":[{"given":"S","family":"McCurdy","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Diego , San Diego, CA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Irei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lozano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"Boisvert","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, HI,","place":["USA"]},{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., Kazan, 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"2025052723511709100_hcab011-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/cyto.2002.0873","article-title":"Interleukin-1F7B (IL-1H4\/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production","volume":"18","author":"Kumar","year":"2002","journal-title":"Cytokine"},{"key":"2025052723511709100_hcab011-B2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.1944","article-title":"IL-37 is a fundamental inhibitor of innate immunity","volume":"11","author":"Nold","year":"2010","journal-title":"Nat 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