{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:36:59Z","timestamp":1765888619475,"version":"3.37.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61971011"],"award-info":[{"award-number":["61971011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Inner Mongolia Autonomous Region","award":["2018MS08046","2020MS08175"],"award-info":[{"award-number":["2018MS08046","2020MS08175"]}]},{"name":"Science Foundation","award":["2020YK02"],"award-info":[{"award-number":["2020YK02"]}]},{"name":"Program for Young Talents of Science and Technology in Universities of IMAR","award":["NJYT-17-B23"],"award-info":[{"award-number":["NJYT-17-B23"]}]},{"name":"Program for Grasslands Talents of IMAR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been linked to the Guillain-Barr\u00e9 syndrome (GBS). The objective of the present study is to identify specific clinical features of cases of GBS reported in the literature associated with SARS-CoV-2 infection. We searched Pubmed, and included single case reports and case series with full text in English, reporting original data of patients with GBS and a confirmed recent SARS-CoV-2 infection. Clinical data were extracted. We identified 28 articles (22 single case reports and 6 case series), reporting on a total of 44 GBS patients with confirmed SARS-CoV-2 infection. SARS-CoV-2 infection was confirmed through serum reverse transcriptase\u2013polymerase chain reaction in 72.7% of cases. A total of 40 patients (91%) had symptoms compatible with SARS-CoV-2 infection before the onset of the GBS. The median period between the onset of symptoms of SARS-CoV-2 infection and symptoms of the GBS was 11.2\u2009days (range, 2\u201323). The most common clinical features were: leg weakness (61.4%), leg paresthesia (50%), arm weakness (50.4%), arm paresthesia (50.4%), hyporeflexia\/areflexia (48%) and ataxia (22.7%). In total, 38.6% (n\u2009=\u200917) were found to have facial paralysis. Among 37 patients in whom nerve-conduction studies and electromyography were performed, of which 26 patients (59.1%)\u00a0were consistent with the acute inflammatory demyelinating polyneuropathy subtype of the GBS. The present retrospective analysis support the role of the SARS-CoV-2 infection in the development of the GBS, may trigger GBS as para-infectious disease, and lead to SARS-CoV-2-associated GBS.<\/jats:p>","DOI":"10.1093\/qjmed\/hcab157","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T19:19:06Z","timestamp":1622056746000},"page":"625-635","source":"Crossref","is-referenced-by-count":18,"title":["SARS-CoV-2-associated Guillain-Barr\u00e9 syndrome is a para-infectious disease"],"prefix":"10.1093","volume":"114","author":[{"given":"X","family":"Li","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Chifeng University, Chifeng 024005, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Chifeng University, Chifeng 024005, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5447-2017","authenticated-orcid":false,"given":"H","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"2021111802305177100_hcab157-B1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"388","author":"Willison","year":"2016","journal-title":"Lancet"},{"key":"2021111802305177100_hcab157-B2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/brain\/118.3.597","article-title":"Guillain-Barr\u00e9 syndrome in northern China. 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