{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:30:36Z","timestamp":1740130236858,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-E-111229"],"award-info":[{"award-number":["TSGH-E-111229"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V106B-020","V107B-010","V107C-181","V108B-012"],"award-info":[{"award-number":["V106B-020","V107B-010","V107C-181","V108B-012"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"publisher","award":["CI-109-21","CI-109-22"],"award-info":[{"award-number":["CI-109-21","CI-109-22"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["107-2314-B-075-063-MY3","108-2314-B-075-037"],"award-info":[{"award-number":["107-2314-B-075-063-MY3","108-2314-B-075-037"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Genetic factors link psychiatric disorders, particularly major depressive disorder (MDD), bipolar disorder, and obsessive-compulsive disorder (OCD), with systemic lupus erythematosus (SLE). Additionally, maternal SLE is a risk factor for long-term developmental problems, particularly learning disabilities, attention disorders, autism spectrum disorder (ASD) and speech disorders, in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>We aimed to determine whether first-degree relatives (FDRs) of patients with SLE have increased risks of SLE and major psychiatric disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and methods<\/jats:title>\n                  <jats:p>Using the Taiwan National Health Insurance Research Database, we recruited 40 462 FDRs of patients with SLE as well as 161 848 matched controls. The risks of major psychiatric disorders, including schizophrenia, bipolar disorder, OCD, MDD, ASD and attention-deficit\/hyperactivity disorder (ADHD), were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The FDRs of patients with SLE had higher risks of SLE (reported as the adjusted relative risk and 95% confidence interval: 14.54; 12.19\u201317.34), MDD (1.23; 1.12\u20131.34), ADHD (1.60; 1.55\u20131.65), OCD (1.41; 1.14\u20131.74) and bipolar disorder (1.18; 1.01\u20131.38) compared with controls. Specifically, male FDRs of patients with SLE had higher risks of SLE and bipolar disorder, whereas female FDRs of patients with SLE had higher risks of MDD and OCD. Differences in the familial relationship (i.e. parents, children, siblings and twins) were consistently associated with higher risks of these disorders compared with controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The FDRs of patients with SLE had higher risks of SLE, MDD, ADHD, OCD and bipolar disorder than the controls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/qjmed\/hcac153","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:42:21Z","timestamp":1656333741000},"page":"813-821","source":"Crossref","is-referenced-by-count":0,"title":["Associations of a family history of lupus with the risks of lupus and major psychiatric disorders in first-degree relatives"],"prefix":"10.1093","volume":"115","author":[{"given":"P -C","family":"Lin","sequence":"first","affiliation":[{"name":"From the Beitou Branch, Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, No. 60, Xinmin Rd., Beitou Dist. , Taipei City 11243, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-5586","authenticated-orcid":false,"given":"C -S","family":"Liang","sequence":"additional","affiliation":[{"name":"From the Beitou Branch, Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, No. 60, Xinmin Rd., Beitou Dist. , Taipei City 11243, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C -K","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist. , Taipei City 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-022X","authenticated-orcid":false,"given":"S -J","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec. 2 , Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"},{"name":"Department of Psychiatry, College of Medicine, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist. , Taipei City 11221, Taiwan"},{"name":"Institute of Brain Sciences, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St. , Beitou Dist., Taipei City 11221, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T -J","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou Dist. , Taipei City 11217, Taiwan"},{"name":"Institute of Hospital and Health Care Administration, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist. , Taipei City 11221, Taiwan"},{"name":"Digital Medicine Center, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist. , Taipei City 11221, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y -M","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec. 2 , Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan"},{"name":"Department of Psychiatry, College of Medicine, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou Dist. , Taipei City 11221, Taiwan"},{"name":"Institute of Brain Sciences, National Yang-Ming Chiao Tung University, No. 155, Sec. 2, Linong St. , Beitou Dist., Taipei City 11221, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"M -H","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec. 2 , 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